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Crosstalk between NK cells and hepatic stellate cells in liver fibrosis (Review)

  • Authors:
    • Yang Zhang
    • Yuan Wu
    • Wenjuan Shen
    • Bingyu Wang
    • Xingxing Yuan
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang 150001, P.R. China, The Graduate School, Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang 150001, P.R. China, Department of Gynaecology, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang 150001, P.R. China, Department of Gastroenterology, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, Heilongjiang 150001, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 208
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    Published online on: May 3, 2022
       https://doi.org/10.3892/mmr.2022.12724
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Abstract

Liver fibrosis is a common pathological process of chronic liver diseases, including viral hepatitis and alcoholic liver disease, and ultimately progresses to irreversible cirrhosis and cancer. Hepatic stellate cells (HSCs) are activated to produce amounts of collagens in response to liver injury, thus triggering the initiation and progression of fibrogenesis. Natural killer (NK) cells serve as the essential component of hepatic innate immunity and are considered to alleviate fibrosis by killing activated HSCs. Current antifibrotic interventions have improved fibrosis, but fail to halt its progression in the advanced stage. Clarifying the interaction between NK cells and HSCs will provide clues to the pathogenesis and potential therapies for advanced liver fibrosis.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Wu Y, Shen W, Wang B and Yuan X: Crosstalk between NK cells and hepatic stellate cells in liver fibrosis (Review). Mol Med Rep 25: 208, 2022.
APA
Zhang, Y., Wu, Y., Shen, W., Wang, B., & Yuan, X. (2022). Crosstalk between NK cells and hepatic stellate cells in liver fibrosis (Review). Molecular Medicine Reports, 25, 208. https://doi.org/10.3892/mmr.2022.12724
MLA
Zhang, Y., Wu, Y., Shen, W., Wang, B., Yuan, X."Crosstalk between NK cells and hepatic stellate cells in liver fibrosis (Review)". Molecular Medicine Reports 25.6 (2022): 208.
Chicago
Zhang, Y., Wu, Y., Shen, W., Wang, B., Yuan, X."Crosstalk between NK cells and hepatic stellate cells in liver fibrosis (Review)". Molecular Medicine Reports 25, no. 6 (2022): 208. https://doi.org/10.3892/mmr.2022.12724
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Wu Y, Shen W, Wang B and Yuan X: Crosstalk between NK cells and hepatic stellate cells in liver fibrosis (Review). Mol Med Rep 25: 208, 2022.
APA
Zhang, Y., Wu, Y., Shen, W., Wang, B., & Yuan, X. (2022). Crosstalk between NK cells and hepatic stellate cells in liver fibrosis (Review). Molecular Medicine Reports, 25, 208. https://doi.org/10.3892/mmr.2022.12724
MLA
Zhang, Y., Wu, Y., Shen, W., Wang, B., Yuan, X."Crosstalk between NK cells and hepatic stellate cells in liver fibrosis (Review)". Molecular Medicine Reports 25.6 (2022): 208.
Chicago
Zhang, Y., Wu, Y., Shen, W., Wang, B., Yuan, X."Crosstalk between NK cells and hepatic stellate cells in liver fibrosis (Review)". Molecular Medicine Reports 25, no. 6 (2022): 208. https://doi.org/10.3892/mmr.2022.12724
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