Open Access

Functions and mechanisms of N6‑methyladenosine in prostate cancer (Review)

  • Authors:
    • Hongyuan Wan
    • Yanyan Feng
    • Junjie Wu
    • Lijie Zhu
    • Yuanyuan Mi
  • View Affiliations

  • Published online on: July 19, 2022     https://doi.org/10.3892/mmr.2022.12796
  • Article Number: 280
  • Copyright: © Wan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Prostate cancer (PCa) has long been a major public health problem affecting men worldwide. Even with treatment, it can develop into castration‑resistant PCa. With the continuous advancement in epigenetics, researchers have explored N6‑methyladenosine (m6A) in search of a more effective and lasting treatment for PCa. m6A is widely distributed in mammalian cells and influences various aspects of mRNA metabolism. Recently, it has been associated with the development or suppression of various types of cancer, including PCa. This review summarizes the recent findings on m6A regulation and its functions and mechanisms in cells, focusing on the various functional proteins operating within m6A in PCa cells. Moreover, the potential clinical value of exploiting m6A modification as an early diagnostic marker in PCa diagnosis and therapeutics was discussed. m6A may also be used as an indicator to evaluate treatment outcome and prognosis.
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September-2022
Volume 26 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Wan H, Feng Y, Wu J, Zhu L and Mi Y: Functions and mechanisms of N6‑methyladenosine in prostate cancer (Review). Mol Med Rep 26: 280, 2022
APA
Wan, H., Feng, Y., Wu, J., Zhu, L., & Mi, Y. (2022). Functions and mechanisms of N6‑methyladenosine in prostate cancer (Review). Molecular Medicine Reports, 26, 280. https://doi.org/10.3892/mmr.2022.12796
MLA
Wan, H., Feng, Y., Wu, J., Zhu, L., Mi, Y."Functions and mechanisms of N6‑methyladenosine in prostate cancer (Review)". Molecular Medicine Reports 26.3 (2022): 280.
Chicago
Wan, H., Feng, Y., Wu, J., Zhu, L., Mi, Y."Functions and mechanisms of N6‑methyladenosine in prostate cancer (Review)". Molecular Medicine Reports 26, no. 3 (2022): 280. https://doi.org/10.3892/mmr.2022.12796