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Article Open Access

Characterization of plasma exosomal microRNAs in responding to radiotherapy of human esophageal squamous cell carcinoma

  • Authors:
    • Nan Miao
    • Wenjie Cai
    • Sijia Ding
    • Yajuan Liu
    • Wanhua Chen
    • Tao Sun
  • View Affiliations / Copyright

    Affiliations: Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen, Fujian 361021, P.R. China, Department of Radiation Oncology, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, Fujian 362000, P.R. China, Department of Clinical Laboratory, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, Fujian 362000, P.R. China
    Copyright: © Miao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 287
    |
    Published online on: July 27, 2022
       https://doi.org/10.3892/mmr.2022.12803
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Abstract

Radiotherapy is one of the main treatment methods for esophageal squamous cell carcinoma (ESCC). Previous research has shown that plasma exosomal microRNAs (miRNAs) can predict therapeutic outcome. In the present study, to identify potential exosomal miRNAs that respond to radiotherapy, plasma exosomal miRNAs from ESCC patients undergoing radiotherapy were isolated and sequenced. Upregulated and downregulated miRNAs were detected from patients pre‑ and post‑radiotherapy, and it was found that they play distinct roles in DNA damage process and endosomal mediated transport. Based on wound healing and Cell Counting Kit‑8 assays in TE‑1 human esophageal cancer cells, it was identified that representative miRNA miR‑652 and miR‑30a alter migration but not proliferation. The present findings identified differentially expressed miRNAs in responding to radiotherapy, and added a reference to explore non‑invasive plasma biomarkers to evaluate therapeutic effects in ESCC.
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Copy and paste a formatted citation
Spandidos Publications style
Miao N, Cai W, Ding S, Liu Y, Chen W and Sun T: Characterization of plasma exosomal microRNAs in responding to radiotherapy of human esophageal squamous cell carcinoma. Mol Med Rep 26: 287, 2022.
APA
Miao, N., Cai, W., Ding, S., Liu, Y., Chen, W., & Sun, T. (2022). Characterization of plasma exosomal microRNAs in responding to radiotherapy of human esophageal squamous cell carcinoma. Molecular Medicine Reports, 26, 287. https://doi.org/10.3892/mmr.2022.12803
MLA
Miao, N., Cai, W., Ding, S., Liu, Y., Chen, W., Sun, T."Characterization of plasma exosomal microRNAs in responding to radiotherapy of human esophageal squamous cell carcinoma". Molecular Medicine Reports 26.3 (2022): 287.
Chicago
Miao, N., Cai, W., Ding, S., Liu, Y., Chen, W., Sun, T."Characterization of plasma exosomal microRNAs in responding to radiotherapy of human esophageal squamous cell carcinoma". Molecular Medicine Reports 26, no. 3 (2022): 287. https://doi.org/10.3892/mmr.2022.12803
Copy and paste a formatted citation
x
Spandidos Publications style
Miao N, Cai W, Ding S, Liu Y, Chen W and Sun T: Characterization of plasma exosomal microRNAs in responding to radiotherapy of human esophageal squamous cell carcinoma. Mol Med Rep 26: 287, 2022.
APA
Miao, N., Cai, W., Ding, S., Liu, Y., Chen, W., & Sun, T. (2022). Characterization of plasma exosomal microRNAs in responding to radiotherapy of human esophageal squamous cell carcinoma. Molecular Medicine Reports, 26, 287. https://doi.org/10.3892/mmr.2022.12803
MLA
Miao, N., Cai, W., Ding, S., Liu, Y., Chen, W., Sun, T."Characterization of plasma exosomal microRNAs in responding to radiotherapy of human esophageal squamous cell carcinoma". Molecular Medicine Reports 26.3 (2022): 287.
Chicago
Miao, N., Cai, W., Ding, S., Liu, Y., Chen, W., Sun, T."Characterization of plasma exosomal microRNAs in responding to radiotherapy of human esophageal squamous cell carcinoma". Molecular Medicine Reports 26, no. 3 (2022): 287. https://doi.org/10.3892/mmr.2022.12803
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