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Macrophage migration inhibitory factor takes part in the lumbar ligamentum flavum hypertrophy

  • Authors:
    • Qi-Lin Lu
    • Zi-Xuan Zheng
    • Yu-Hui Ye
    • Jiang-Yun Lu
    • Yu-Qi Zhong
    • Chao Sun
    • Cheng-Jie Xiong
    • Gong-Xu Yang
    • Feng Xu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, General Hospital of Central Theater Command, Wuhan, Hubei 430070, P.R. China, College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China, Medical Laboratory, Hubei 672 Orthopedics Hospital of Integrated Chinese and Western Medicine, Wuhan, Hubei 430079, P.R. China
    Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 289
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    Published online on: July 27, 2022
       https://doi.org/10.3892/mmr.2022.12805
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Abstract

The present study aimed to observe the content difference of macrophage migration inhibitory factor [MIF; novoprotein recombinant human MIF (n‑6his) (ch33)], TGFβ1 and MMP13 in patients with and without ligamentum flavum (LF) hypertrophy and investigate the roles of MIF in LF hypertrophy. The concentration of MIF, TGFβ1 and MMP13 in LF were detected by ELISA in a lumbar spinal stenosis (LSS) group and a lumbar disc herniation (LDH) group. Culture of primary LFs and identification were performed for the subsequent study. Cell treatments and cell proliferation assay by CCK‑8 was performed. Western blot and quantitative PCR analysis were used to detect the expression of TGFβ1, MMP13, type I collagen (COL‑1) and type III collagen (COL‑3) and Src which were promoted by MIF. The concentration of MIF, TGFβ1 and MMP13 were higher in the LSS group compared with the LDH group. Culture of primary LFs and identification were performed. Significant difference in LFs proliferation occurred with treatment by MIF at a concentration of 40 nM for 48 h (P<0.05). The gene and protein expression of TGFβ1, MMP13, COL‑1, COL‑3 and Src were promoted by MIF (P<0.05). Proliferation of LFs was induced by MIF and MIF‑induced proliferation of LFs was inhibited by PP1 (a Src inhibitor). MIF may promote the proliferation of LFs through the Src kinase signaling pathway and can promote extracellular matrix changes by its pro‑inflammatory effect. MIF and its mediated inflammatory reaction are driving factors of LF hypertrophy.
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1 

Sakai Y, Ito S, Hida T, Ito K, Harada A and Watanabe K: Clinical outcome of lumbar spinal stenosis based on new classification according to hypertrophied ligamentum flavum. J Orthop Sci. 22:27–33. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Shafaq N, Suzuki A, Terai H, Wakitani S and Nakamura H: Cellularity and cartilage matrix increased in hypertrophied ligamentum flavum: Histopathological analysis focusing on the mechanical stress and bone morphogenetic protein signaling. J Spinal Disord Tech. 25:107–115. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Salimi H, Suzuki A, Habibi H, Orita K, Hori Y, Yabu A, Terai H, Tamai K and Nakamura H: Biglycan expression and its function in human ligamentum flavum. Sci Rep. 11:48672021. View Article : Google Scholar : PubMed/NCBI

4 

Wang B, Gao C, Zhang P, Sun W, Zhang J and Gao J: The increased motion of lumbar induces ligamentum flavum hypertrophy in a rat model. BMC Musculoskelet Disord. 22:3342021. View Article : Google Scholar : PubMed/NCBI

5 

Sairyo K, Biyani A, Goel VK, Leaman DW, Booth R Jr, Thomas J, Ebraheim NA, Cowgill IA and Mohan SE: Lumbar ligamentum flavum hypertrophy is due to accumulation of inflammation-related scar tissue. Spine (Phila Pa 1976). 32:E340–E347. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Saito T, Hara M, Kumamaru H, Kobayakawa K, Yokota K, Kijima K, Yoshizaki S, Harimaya K, Matsumoto Y, Kawaguchi K, et al: Macrophage infiltration is a causative factor for ligamentum flavum hypertrophy through the activation of collagen production in fibroblasts. Am J Pathol. 187:2831–2840. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Park JO, Lee BH, Kang YM, Kim TH, Yoon JY, Kim H, Kwon UH, Lee KI, Lee HM and Moon SH: Inflammatory cytokines induce fibrosis and ossification of human ligamentum flavum cells. J Spinal Disord Tech. 26:E6–E12. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Wang L, Chang M, Tian Y, Yan J, Xu W, Yuan S, Zhang K and Liu X: The role of Smad2 in transforming growth factor β-Induced hypertrophy of ligamentum flavum. World Neurosurg. 151:e128–e136. 2021. View Article : Google Scholar : PubMed/NCBI

9 

Cui G, Watanabe K, Miyauchi Y, Hosogane N, Tsuji T, Ishii K, Nakamura M, Toyama Y, Chiba K, Miyamoto T and Matsumoto M: Matrix metalloproteinase 13 in the ligamentum flavum from lumbar spinal canal stenosis patients with and without diabetes mellitus. J Orthop Sci. 16:785–790. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Xue YM, Deng CY, Wei W, Liu FZ, Yang H, Liu Y, Li X, Wang Z, Kuang SJ, Wu SL and Rao F: Macrophage migration inhibitory factor promotes cardiac fibroblast proliferation through the Src kinase signaling pathway. Mol Med Rep. 17:3425–3431. 2018.PubMed/NCBI

11 

Zheng Y, Li X, Qian X, Wang Y, Lee JH, Xia Y, Hawke DH, Zhang G, Lyu J and Lu Z: Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation. Nat Cell Biol. 17:1348–1355. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Yao Y, Deng Q, Song W, Zhang H, Li Y, Yang Y, Fan X, Liu M, Shang J, Sun C, et al: MIF plays a key role in regulating tissue-specific chondro-osteogenic differentiation fate of human cartilage endplate stem cells under hypoxia. Stem Cell Reports. 7:249–262. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Hertelendy J, Reumuth G, Simons D, Stoppe C, Kim BS, Stromps JP, Fuchs PC, Bernhagen J, Pallua N and Grieb G: Macrophage migration inhibitory factor-a favorable marker in inflammatory diseases? Curr Med Chem. 25:601–605. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Lu QL, Wang XZ, Xie W, Chen XW, Zhu YL and Li XG: Macrophage migration inhibitory factor may contribute to hypertrophy of lumbar ligamentum flavum in type 2 diabetes mellitus. Chin Med J (Engl). 133:623–625. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Arocho A, Chen B, Ladanyi M and Pan Q: Validation of the 2-DeltaDeltaCt calculation as an alternate method of data analysis for quantitative PCR of BCR-ABL P210 transcripts. Diagn Mol Pathol. 15:56–61. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Sun C, Zhang H, Wang X and Liu X: Ligamentum flavum fibrosis and hypertrophy: Molecular pathways, cellular mechanisms and future directions. FASEB J. 34:9854–9868. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Takeda H, Nagai S, Ikeda D, Kaneko S, Tsuji T and Fujita N: Collagen profiling of ligamentum flavum in patients with lumbar spinal canal stenosis. J Orthop Sci. 26:560–565. 2021. View Article : Google Scholar : PubMed/NCBI

18 

Kosaka H, Sairyo K, Biyani A, Leaman D, Yeasting R, Higashino K, Sakai T, Katoh S, Sano T, Goel VK and Yasui N: Pathomechanism of loss of elasticity and hypertrophy of lumbar ligamentum flavum in elderly patients with lumbar spinal canal stenosis. Spine (Phila Pa 1976). 32:2805–2811. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Melancia JL, Francisco AF and Antunes JL: Spinal stenosis. Handb Clin Neurol. 119:541–549. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Yan B, Zeng C, Chen Y, Huang M, Yao N, Zhang J, Yan B, Tang J, Wang L and Zhang Z: Mechanical Stress-Induced IGF-1 Facilitates col-I and col-III Synthesis via the IGF-1R/AKT/mTORC1 Signaling Pathway. Stem Cells Int. 2021:55536762021. View Article : Google Scholar : PubMed/NCBI

21 

Sun C, Wang Z, Tian JW and Wang YH: Leptin-induced inflammation by activating IL-6 expression contributes to the fibrosis and hypertrophy of ligamentum flavum in lumbar spinal canal stenosis. Biosci Rep. 38:BSR201712142018. View Article : Google Scholar : PubMed/NCBI

22 

Chen MH, Hu CK, Chen PR, Chen YS, Sun JS and Chen MH: Dose-dependent regulation of cell proliferation and collagen degradation by estradiol on ligamentum flavum. BMC Musculoskelet Disord. 15:2382014. View Article : Google Scholar : PubMed/NCBI

23 

Sudhir G, Vignesh Jayabalan S, Gadde S, Venkatesh Kumar G and Karthik Kailash K: Analysis of factors influencing ligamentum flavum thickness in lumbar spine-A radiological study of 1070 disc levels in 214 patients. Clin Neurol Neurosurg. 182:19–24. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Kasama T, Ohtsuka K, Sato M, Takahashi R, Wakabayashi K and Kobayashi K: Macrophage migration inhibitory factor: A multifunctional cytokine in rheumatic diseases. Arthritis. 2010:1062022010. View Article : Google Scholar : PubMed/NCBI

25 

Sugimoto K, Nakamura T, Tokunaga T, Uehara Y, Okada T, Taniwaki T, Fujimoto T and Mizuta H: Matrix metalloproteinase promotes elastic fiber degradation in ligamentum flavum degeneration. PLoS One. 13:e02008722018. View Article : Google Scholar : PubMed/NCBI

26 

Onodera S, Nishihira J, Koyama Y, Majima T, Aoki Y, Ichiyama H, Ishibashi T and Minami A: Macrophage migration inhibitory factor up-regulates the expression of interleukin-8 messenger RNA in synovial fibroblasts of rheumatoid arthritis patients: Common transcriptional regulatory mechanism between interleukin-8 and interleukin-1beta. Arthritis Rheum. 50:1437–1447. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Leng L and Bucala R: Macrophage migration inhibitory factor. Crit Care Med. 33 (12 Suppl):S475–S477. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Su Y and Wang Y, Zhou Y, Zhu Z, Zhang Q, Zhang X, Wang W, Gu X, Guo A and Wang Y: Macrophage migration inhibitory factor activates inflammatory responses of astrocytes through interaction with CD74 receptor. Oncotarget. 8:2719–2730. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Li H, Zhao C, Tian Y, Lu J, Zhang G, Liang S, Chen D, Liu X, Kuang W and Zhu M: Src family kinases and pulmonary fibrosis: A review. Biomed Pharmacother. 127:1101832020. View Article : Google Scholar : PubMed/NCBI

30 

Koudelková L, Brábek J and Rosel D: Src kinase: Key effector in mechanosignalling. Int J Biochem Cell Biol. 131:1059082021. View Article : Google Scholar : PubMed/NCBI

31 

Ntanasis-Stathopoulos I, Fotopoulos G, Tzanninis IG and Kotteas EA: The emerging role of tyrosine kinase inhibitors in ovarian cancer treatment: A systematic review. Cancer Invest. 34:313–339. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Rao F, Deng CY, Wu SL, Xiao DZ, Yu XY, Kuang SJ, Lin QX and Shan ZX: Involvement of Src in L-type Ca2+ channel depression induced by macrophage migration inhibitory factor in atrial myocytes. J Mol Cell Cardiol. 47:586–594. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Cai T, Kuang Y, Zhang C, Zhang Z, Chen L, Li B, Li Y, Wang Y, Yang H, Han Q and Zhu Y: Glucose-6-phosphate dehydrogenase and NADPH oxidase 4 control STAT3 activity in melanoma cells through a pathway involving reactive oxygen species, c-SRC and SHP2. Am J Cancer Res. 5:1610–1620. 2015.PubMed/NCBI

34 

Zernecke A, Bernhagen J and Weber C: Macrophage migration inhibitory factor in cardiovascular disease. Circulation. 117:1594–1602. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Jankauskas SS, Wong DWL, Bucala R, Djudjaj S and Boor P: Evolving complexity of MIF signaling. Cell Signal. 57:76–88. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Presti M, Mazzon E, Basile MS and Maria CP: Overexpression of macrophage migration inhibitory factor and functionally-related genes, D-DT, CD74, CD44, CXCR2 and CXCR4, in glioblastoma. Oncol Lett. 16:2881–2886. 2018.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lu Q, Zheng Z, Ye Y, Lu J, Zhong Y, Sun C, Xiong C, Yang G and Xu F: Macrophage migration inhibitory factor takes part in the lumbar ligamentum flavum hypertrophy. Mol Med Rep 26: 289, 2022.
APA
Lu, Q., Zheng, Z., Ye, Y., Lu, J., Zhong, Y., Sun, C. ... Xu, F. (2022). Macrophage migration inhibitory factor takes part in the lumbar ligamentum flavum hypertrophy. Molecular Medicine Reports, 26, 289. https://doi.org/10.3892/mmr.2022.12805
MLA
Lu, Q., Zheng, Z., Ye, Y., Lu, J., Zhong, Y., Sun, C., Xiong, C., Yang, G., Xu, F."Macrophage migration inhibitory factor takes part in the lumbar ligamentum flavum hypertrophy". Molecular Medicine Reports 26.3 (2022): 289.
Chicago
Lu, Q., Zheng, Z., Ye, Y., Lu, J., Zhong, Y., Sun, C., Xiong, C., Yang, G., Xu, F."Macrophage migration inhibitory factor takes part in the lumbar ligamentum flavum hypertrophy". Molecular Medicine Reports 26, no. 3 (2022): 289. https://doi.org/10.3892/mmr.2022.12805
Copy and paste a formatted citation
x
Spandidos Publications style
Lu Q, Zheng Z, Ye Y, Lu J, Zhong Y, Sun C, Xiong C, Yang G and Xu F: Macrophage migration inhibitory factor takes part in the lumbar ligamentum flavum hypertrophy. Mol Med Rep 26: 289, 2022.
APA
Lu, Q., Zheng, Z., Ye, Y., Lu, J., Zhong, Y., Sun, C. ... Xu, F. (2022). Macrophage migration inhibitory factor takes part in the lumbar ligamentum flavum hypertrophy. Molecular Medicine Reports, 26, 289. https://doi.org/10.3892/mmr.2022.12805
MLA
Lu, Q., Zheng, Z., Ye, Y., Lu, J., Zhong, Y., Sun, C., Xiong, C., Yang, G., Xu, F."Macrophage migration inhibitory factor takes part in the lumbar ligamentum flavum hypertrophy". Molecular Medicine Reports 26.3 (2022): 289.
Chicago
Lu, Q., Zheng, Z., Ye, Y., Lu, J., Zhong, Y., Sun, C., Xiong, C., Yang, G., Xu, F."Macrophage migration inhibitory factor takes part in the lumbar ligamentum flavum hypertrophy". Molecular Medicine Reports 26, no. 3 (2022): 289. https://doi.org/10.3892/mmr.2022.12805
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