Open Access

Role of ROS‑mediated autophagy in melanoma (Review)

  • Authors:
    • Xuebing Zhang
    • Huaijun Li
    • Chengxiang Liu
    • Xingxing Yuan
  • View Affiliations

  • Published online on: August 9, 2022     https://doi.org/10.3892/mmr.2022.12819
  • Article Number: 303
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Melanoma is the most aggressive form of skin cancer with the poorest prognosis and its pathogenesis has yet to be fully elucidated. As key factors that regulate cellular homeostasis, both reactive oxygen species (ROS) and autophagy are involved in the development of melanoma, from melanomagenesis to progression and drug resistance. However, the interaction between ROS and autophagy in the etiology and treatment of melanoma is not well characterized. The present review examined the production of ROS and the role of oxidative stress in melanoma, and summarized the role of ROS‑mediated autophagy in melanomagenesis and melanoma cell fate decision following treatment with various anticancer drugs. The present findings may lead to a better understanding of the pathogenesis and progression of melanoma, and suggest promising treatment options for this disease.
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October-2022
Volume 26 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang X, Li H, Liu C and Yuan X: Role of ROS‑mediated autophagy in melanoma (Review). Mol Med Rep 26: 303, 2022
APA
Zhang, X., Li, H., Liu, C., & Yuan, X. (2022). Role of ROS‑mediated autophagy in melanoma (Review). Molecular Medicine Reports, 26, 303. https://doi.org/10.3892/mmr.2022.12819
MLA
Zhang, X., Li, H., Liu, C., Yuan, X."Role of ROS‑mediated autophagy in melanoma (Review)". Molecular Medicine Reports 26.4 (2022): 303.
Chicago
Zhang, X., Li, H., Liu, C., Yuan, X."Role of ROS‑mediated autophagy in melanoma (Review)". Molecular Medicine Reports 26, no. 4 (2022): 303. https://doi.org/10.3892/mmr.2022.12819