Open Access

Role of SUMOylation of STAT1 in tubular epithelial‑mesenchymal transition induced by high glucose

  • Authors:
    • Cunyang Gu
    • Feng Gao
    • Shiqi Zhang
    • Lihua Kang
    • Wei Zhang
    • Xiaojuan Feng
    • Jinxi Liu
    • Yuexin Tian
    • Qun Wei
    • Yunxia Du
    • Yujia Xing
    • Qingjuan Liu
    • Shuxia Liu
  • View Affiliations

  • Published online on: January 2, 2023     https://doi.org/10.3892/mmr.2023.12929
  • Article Number: 42
  • Copyright: © Gu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Tubulointerstitial fibrosis (TIF) is an important pathological change that occurs during the development of diabetic kidney disease. The epithelial‑mesenchymal transition (EMT) of renal tubular epithelial cells is a manifestation of TIF. STAT1, a member of the STAT family of transcription factors, can be modified by the small ubiquitin‑related modifier (SUMO), thus affecting the activity of STAT1. The present study investigated the role of STAT1 SUMOylation in high glucose‑induced tubular EMT by western blotting, immunocytochemistry, immunofluorescence, co‑immunoprecipitation and dual luciferase reporter analysis. The results indicated that in the process of high glucose‑induced EMT, STAT1 activation protected the cells from EMT. However, high glucose also increased the SUMOylation of STAT1, which prevented STAT1 from exerting an effective protective role by inhibiting its activity.
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February-2023
Volume 27 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Gu C, Gao F, Zhang S, Kang L, Zhang W, Feng X, Liu J, Tian Y, Wei Q, Du Y, Du Y, et al: Role of SUMOylation of STAT1 in tubular epithelial‑mesenchymal transition induced by high glucose. Mol Med Rep 27: 42, 2023
APA
Gu, C., Gao, F., Zhang, S., Kang, L., Zhang, W., Feng, X. ... Liu, S. (2023). Role of SUMOylation of STAT1 in tubular epithelial‑mesenchymal transition induced by high glucose. Molecular Medicine Reports, 27, 42. https://doi.org/10.3892/mmr.2023.12929
MLA
Gu, C., Gao, F., Zhang, S., Kang, L., Zhang, W., Feng, X., Liu, J., Tian, Y., Wei, Q., Du, Y., Xing, Y., Liu, Q., Liu, S."Role of SUMOylation of STAT1 in tubular epithelial‑mesenchymal transition induced by high glucose". Molecular Medicine Reports 27.2 (2023): 42.
Chicago
Gu, C., Gao, F., Zhang, S., Kang, L., Zhang, W., Feng, X., Liu, J., Tian, Y., Wei, Q., Du, Y., Xing, Y., Liu, Q., Liu, S."Role of SUMOylation of STAT1 in tubular epithelial‑mesenchymal transition induced by high glucose". Molecular Medicine Reports 27, no. 2 (2023): 42. https://doi.org/10.3892/mmr.2023.12929