Open Access

Role of DNA methylation and non‑coding RNAs expression in pathogenesis, detection, prognosis, and therapy‑resistant ovarian carcinoma (Review)

  • Authors:
    • Victor M. Del Castillo Falconi
    • Jenny A. Godinez Rodriguez
    • Verónica Fragoso‑Ontiveros
    • Laura Contreras‑Espinosa
    • Abraham Pedroza‑Torres
    • José Díaz‑Chávez
    • Luis A. Herrera
  • View Affiliations

  • Published online on: April 1, 2025     https://doi.org/10.3892/mmr.2025.13509
  • Article Number: 144
  • Copyright: © Del Castillo Falconi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ovarian cancer is the deadliest gynecological cancer globally, with epithelial ovarian cancer (EOC) comprising up to 90% of cases. A molecular characterization linking the histological subtypes with tumor grade in EOC has been suggested. Variations in genetic biomarkers such as BRCA1/2, MSH2, MLH1/6, BRIP1, and RAD51C/D have been studied in EOC. In addition, molecular characteristics, including DNA methylation and RNA transcription, are being explored as potential new biomarkers for the diagnosis and prognosis of this type of neoplasia. The present review focused on the role of DNA methylation and non‑coding RNA expression in the development of ovarian carcinomas and their association with diagnosis, prognosis, and the resistance of cancer cells to radiotherapy and chemotherapy. The present review considered the transition from the DNA structure to the RNA expression in ovarian carcinoma.
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June-2025
Volume 31 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Del Castillo Falconi VM, Godinez Rodriguez JA, Fragoso‑Ontiveros V, Contreras‑Espinosa L, Pedroza‑Torres A, Díaz‑Chávez J and Herrera LA: Role of DNA methylation and non‑coding RNAs expression in pathogenesis, detection, prognosis, and therapy‑resistant ovarian carcinoma (Review). Mol Med Rep 31: 144, 2025.
APA
Del Castillo Falconi, V.M., Godinez Rodriguez, J.A., Fragoso‑Ontiveros, V., Contreras‑Espinosa, L., Pedroza‑Torres, A., Díaz‑Chávez, J., & Herrera, L.A. (2025). Role of DNA methylation and non‑coding RNAs expression in pathogenesis, detection, prognosis, and therapy‑resistant ovarian carcinoma (Review). Molecular Medicine Reports, 31, 144. https://doi.org/10.3892/mmr.2025.13509
MLA
Del Castillo Falconi, V. M., Godinez Rodriguez, J. A., Fragoso‑Ontiveros, V., Contreras‑Espinosa, L., Pedroza‑Torres, A., Díaz‑Chávez, J., Herrera, L. A."Role of DNA methylation and non‑coding RNAs expression in pathogenesis, detection, prognosis, and therapy‑resistant ovarian carcinoma (Review)". Molecular Medicine Reports 31.6 (2025): 144.
Chicago
Del Castillo Falconi, V. M., Godinez Rodriguez, J. A., Fragoso‑Ontiveros, V., Contreras‑Espinosa, L., Pedroza‑Torres, A., Díaz‑Chávez, J., Herrera, L. A."Role of DNA methylation and non‑coding RNAs expression in pathogenesis, detection, prognosis, and therapy‑resistant ovarian carcinoma (Review)". Molecular Medicine Reports 31, no. 6 (2025): 144. https://doi.org/10.3892/mmr.2025.13509