Open Access

Advances in research on flavonoids in tumor immunotherapy (Review)

  • Authors:
    • Chaoguang Yan
    • Guangchun Wang
  • View Affiliations

  • Published online on: April 4, 2025     https://doi.org/10.3892/mmr.2025.13515
  • Article Number: 150
  • Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cancer immunotherapy is an approach used in anti‑tumor treatment; however, its efficacy is limited to specific tumor types that are inherently sensitive to immune system modulation. Expanding the scope of indications and enhancing the efficacy of cancer immunotherapy are key goals for continued advancement. Flavonoids modulate the tumor‑immunosuppressive microenvironment. Integrating flavonoids with immunotherapeutic modalities, including cancer vaccines, immune checkpoint inhibitors and adoptive immune‑cell therapy, has potential in terms of augmenting the therapeutic efficacy of immunotherapy. The present review aimed to summarize flavonoids that enhance cancer immunotherapy, focusing on their underlying mechanisms and the application of nanotechnology to overcome inherent limitations such as poor solubility, low bioavailability, rapid metabolism, and instability under physiological conditions, thereby highlighting the potential of flavonoids in advancing cancer immunotherapy.
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June-2025
Volume 31 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Yan C and Wang G: Advances in research on flavonoids in tumor immunotherapy (Review). Mol Med Rep 31: 150, 2025.
APA
Yan, C., & Wang, G. (2025). Advances in research on flavonoids in tumor immunotherapy (Review). Molecular Medicine Reports, 31, 150. https://doi.org/10.3892/mmr.2025.13515
MLA
Yan, C., Wang, G."Advances in research on flavonoids in tumor immunotherapy (Review)". Molecular Medicine Reports 31.6 (2025): 150.
Chicago
Yan, C., Wang, G."Advances in research on flavonoids in tumor immunotherapy (Review)". Molecular Medicine Reports 31, no. 6 (2025): 150. https://doi.org/10.3892/mmr.2025.13515