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Brevilin A inhibits IL‑17A‑induced inflammation in psoriasis by modulating HSP 70 

  • Authors:
    • Chia-Ling Li
    • Kuei-Ying Yeh
    • Wen-Nan Huang
    • Chung-Yang Yen
    • Kai-Chun Wang
    • En-Chih Liao
    • Ting-Yu Chou
    • Hung-Sen Huang
    • Sheng-Jie Yu
  • View Affiliations / Copyright

    Affiliations: Children's Medical Center, Taichung Veterans General Hospital, Taichung 407, Taiwan, R.O.C., Department of Physical Therapy, College of Medical and Health Care, Hungkuang University, Taichung 433, Taiwan, R.O.C., Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan, R.O.C., School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan, R.O.C., Division of Allergy‑Immunology-Rheumatology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan, R.O.C., Institute of Biomedical Sciences, MacKay Medical College, New Taipei City 252, Taiwan, R.O.C., Department of Medical Research, Taichung Veterans General Hospital, Taichung 407, Taiwan, R.O.C., Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan, R.O.C., Integrated Care Center of Psoriatic Disease, Taichung Veterans General Hospital, Taichung 407, Taiwan, R.O.C.
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 156
    |
    Published online on: April 8, 2025
       https://doi.org/10.3892/mmr.2025.13521
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Abstract

Psoriasis, which is characterized by keratinocyte hyperproliferation, presents complex management challenges. The heat shock protein 70 (HSP 70) family, which is essential in protein folding and stress responses, also modulates inflammation, suggesting its therapeutic potential in inflammation‑driven diseases. The present study aimed to explore the effects of brevilin A, a natural compound known to alleviate imiquimod‑induced psoriasis, on HSP 70 expression and proinflammatory cytokine production in HaCaT cells stimulated with IL‑17A. An HSP 70 inhibitor was used to determine its role in cytokine regulation, and the effect of brevilin A on skin pathology in mice was examined via immunohistochemistry and hematoxylin and eosin staining. The results revealed that brevilin A markedly decreased IL‑6 and IL‑8 levels after IL‑17A stimulation at both 9 and 24 h in HaCaT cells, and increased HSP 70 and HSP 90 expression levels. Notably, the brevilin A‑induced suppression of cytokine levels was reversed when cells were co‑treated with the HSP 70 inhibitor. In vivo, brevilin A enhanced HSP 70 expression and reduced skin hyperproliferation. These findings suggested that brevilin A may modulate HSP 70 expression and dampen the inflammatory response induced by IL‑17A, indicating its potential as an innovative treatment for psoriasis.
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Copy and paste a formatted citation
Spandidos Publications style
Li C, Yeh K, Huang W, Yen C, Wang K, Liao E, Chou T, Huang H and Yu S: Brevilin A inhibits IL‑17A‑induced inflammation in psoriasis by modulating HSP 70 . Mol Med Rep 31: 156, 2025.
APA
Li, C., Yeh, K., Huang, W., Yen, C., Wang, K., Liao, E. ... Yu, S. (2025). Brevilin A inhibits IL‑17A‑induced inflammation in psoriasis by modulating HSP 70 . Molecular Medicine Reports, 31, 156. https://doi.org/10.3892/mmr.2025.13521
MLA
Li, C., Yeh, K., Huang, W., Yen, C., Wang, K., Liao, E., Chou, T., Huang, H., Yu, S."Brevilin A inhibits IL‑17A‑induced inflammation in psoriasis by modulating HSP 70 ". Molecular Medicine Reports 31.6 (2025): 156.
Chicago
Li, C., Yeh, K., Huang, W., Yen, C., Wang, K., Liao, E., Chou, T., Huang, H., Yu, S."Brevilin A inhibits IL‑17A‑induced inflammation in psoriasis by modulating HSP 70 ". Molecular Medicine Reports 31, no. 6 (2025): 156. https://doi.org/10.3892/mmr.2025.13521
Copy and paste a formatted citation
x
Spandidos Publications style
Li C, Yeh K, Huang W, Yen C, Wang K, Liao E, Chou T, Huang H and Yu S: Brevilin A inhibits IL‑17A‑induced inflammation in psoriasis by modulating HSP 70 . Mol Med Rep 31: 156, 2025.
APA
Li, C., Yeh, K., Huang, W., Yen, C., Wang, K., Liao, E. ... Yu, S. (2025). Brevilin A inhibits IL‑17A‑induced inflammation in psoriasis by modulating HSP 70 . Molecular Medicine Reports, 31, 156. https://doi.org/10.3892/mmr.2025.13521
MLA
Li, C., Yeh, K., Huang, W., Yen, C., Wang, K., Liao, E., Chou, T., Huang, H., Yu, S."Brevilin A inhibits IL‑17A‑induced inflammation in psoriasis by modulating HSP 70 ". Molecular Medicine Reports 31.6 (2025): 156.
Chicago
Li, C., Yeh, K., Huang, W., Yen, C., Wang, K., Liao, E., Chou, T., Huang, H., Yu, S."Brevilin A inhibits IL‑17A‑induced inflammation in psoriasis by modulating HSP 70 ". Molecular Medicine Reports 31, no. 6 (2025): 156. https://doi.org/10.3892/mmr.2025.13521
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