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Identification of metabolites associated with capecitabine‑induced hand‑foot syndrome using untargeted metabolomics in patients with cancer

  • Authors:
    • Yuru Bai
    • Hong Chen
    • Leying Gu
    • Bo Shi
    • Zhen Wang
    • Yuanyuan Duanmu
    • Ying Hu
    • Yu Wang
    • Chaoyi Zhang
    • Zhaotian Su
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Nanjing Jiangning Hospital of Traditional Chinese Medicine Affiliated to China Pharmaceutical University, Nanjing, Jiangsu 211100, P.R. China, Department of Basic Medicine, College of Health and Nursing, Wuxi Taihu University, Wuxi, Jiangsu 214063, P.R. China, Department of Laboratory Medicine, Nanjing Jiangning Hospital of Traditional Chinese Medicine Affiliated to China Pharmaceutical University, Nanjing, Jiangsu 211100, P.R. China
    Copyright: © Bai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 203
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    Published online on: May 14, 2025
       https://doi.org/10.3892/mmr.2025.13568
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Abstract

Hand‑foot syndrome (HFS) is defined as a major adverse reaction to capecitabine; however, the underlying mechanisms remain unclear. In total, 85 patients who were taking oral capecitabine were included in the present study and these patients were divided into HFS‑positive and HFS‑negative groups. Serum samples were collected from patients and an untargeted metabolomics analysis was conducted using ultra‑high performance liquid chromatography‑mass spectrometry/mass spectrometry. The present study aimed to investigate the presence of metabolites in the serum of patients that developed HFS in response to capecitabine treatment. A total of 193 differential metabolites were identified, with 134 upregulated and 59 downregulated. Bioinformatics analysis revealed four novel metabolites that may be associated with HFS. Subsequent in vitro experiments were conducted to explore the damaging effects of capecitabine and its associated metabolites on human adult keratinocyte cell line, TPA‑treated (HaCaT) cells. Results of the present study revealed that aciclovir and lamivudine affected cellular damage at the highest level. In conclusion, the present study aimed to systematically and comprehensively describe the metabolites present in patients with capecitabine‑induced HFS and may further the current understanding of the capecitabine pathways that play a key role in HFS.
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View References

1 

Jo JH, Kim YT, Choi HS, Kim HG, Lee HS, Choi YW, Kim DU, Lee KH, Kim EJ, Han JH, et al: Efficacy of GV1001 with gemcitabine/capecitabine in previously untreated patients with advanced pancreatic ductal adenocarcinoma having high serum eotaxin levels (KG4/2015): An open-label, randomised, Phase 3 trial. Br J Cancer. 130:43–52. 2024. View Article : Google Scholar : PubMed/NCBI

2 

Primrose JN, Fox RP, Palmer DH, Malik HZ, Prasad R, Mirza D, Anthony A, Corrie P, Falk S, Finch-Jones M, et al: Capecitabine compared with observation in resected biliary tract cancer (BILCAP): A randomised, controlled, multicentre, phase 3 study. Lancet Oncol. 20:663–673. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Knikman JE, Rosing H, Guchelaar HJ, Cats A and Beijnen JH: A review of the bioanalytical methods for the quantitative determination of capecitabine and its metabolites in biological matrices. Biomed Chromatogr. 34:e47322020. View Article : Google Scholar : PubMed/NCBI

4 

Alzahrani SM, Al Doghaither HA, Al-Ghafari AB and Pushparaj PN: 5-Fluorouracil and capecitabine therapies for the treatment of colorectal cancer (Review). Oncol Rep. 50:1752023. View Article : Google Scholar : PubMed/NCBI

5 

Wang Z, Li X, Yang Y, Zhang F, Li M and Chen W, Gao S and Chen W: A sensitive and efficient method for determination of capecitabine and its five metabolites in human plasma based on one-step liquid-liquid extraction. J Anal Methods Chem. 2019:93717902019. View Article : Google Scholar : PubMed/NCBI

6 

King TL, Voon PJ, Yuen KH and Mohamed Noor DA: Hand-foot syndrome in cancer patients on capecitabine: Examining prevalence, impacts, and associated risk factors at a cancer centre in Malaysia. Support Care Cancer. 32:3452024. View Article : Google Scholar : PubMed/NCBI

7 

de Queiroz MVR, de Medeiros ACTR, Toledo SP, de Abreu Sarmenghi KD and de Vasconcellos VF: Hand-foot syndrome caused by capecitabine: incidence, risk factors and the role of dermatological evaluation. Ecancermedicalscience. 16:13902022.PubMed/NCBI

8 

Ahn HR, Lee SK, Youn HJ, Yun SK and Lee IJ: Stevens-Johnson syndrome and concurrent hand foot syndrome during treatment with capecitabine: A case report. World J Clin Cases. 9:4279–4284. 2021. View Article : Google Scholar : PubMed/NCBI

9 

Lou Y, Wang Q, Zheng J, Hu H, Liu L, Hong D and Zeng S: Possible pathways of capecitabine-induced hand-foot syndrome. Chem Res Toxicol. 29:1591–1601. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Hiromoto S, Kawashiri T, Yamanaka N, Kobayashi D, Mine K, Inoue M, Uchida M and Shimazoe T: Use of omeprazole, the proton pump inhibitor, as a potential therapy for the capecitabine-induced hand-foot syndrome. Sci Rep. 11:89642021. View Article : Google Scholar : PubMed/NCBI

11 

Lu W, Huang Z, Chen S, Lv H, Chen X, Lei J, Ke C, Hong C, Wei Y, Su R, et al: The effectiveness of EVOSKIN(R)Palm and sole moisturizing cream in treating capecitabine-associated hand-foot syndrome: A randomized double-blind clinical trial. Ann Palliat Med. 10:3009–3017. 2021. View Article : Google Scholar : PubMed/NCBI

12 

Schag CC, Heinrich RL and Ganz PA: Karnofsky performance status revisited: Reliability, validity, and guidelines. J Clin Oncol. 2:187–193. 1984. View Article : Google Scholar : PubMed/NCBI

13 

Freites-Martinez A, Santana N, Arias-Santiago S and Viera A: Using the common terminology criteria for adverse events (CTCAE-Version 5.0) to evaluate the severity of adverse events of anticancer therapies. Actas Dermosifiliogr (Engl Ed). 112:90–92. 2021.(In English, Spanish). View Article : Google Scholar : PubMed/NCBI

14 

R Core Team, . R: A language and environment for statistical computing. R Foundation for Statistical Computing; Vienna: 2021

15 

Li C, Zhang J, Wu R, Liu Y, Hu X, Yan Y and Ling X: A novel strategy for rapidly and accurately screening biomarkers based on ultraperformance liquid chromatography-mass spectrometry metabolomics data. Anal Chim Acta. 1063:47–56. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Karaman I: Preprocessing and pretreatment of metabolomics data for statistical analysis. Adv Exp Med Biol. 965:145–161. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Yang J, Zhao X, Lu X, Lin X and Xu G: A data preprocessing strategy for metabolomics to reduce the mask effect in data analysis. Front Mol Biosci. 2:42015. View Article : Google Scholar : PubMed/NCBI

18 

Liang JH, Lin Y, Ouyang T, Tang W, Huang Y, Ye W, Zhao JY, Wang ZN and Ma CC: Nuclear magnetic resonance-based metabolomics and metabolic pathway networks from patient-matched esophageal carcinoma, adjacent noncancerous tissues and urine. World J Gastroenterol. 25:3218–3230. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Berry L and Venkatesan P: Aciclovir-induced neurotoxicity: Utility of CSF and serum CMMG levels in diagnosis. J Clin Virol. 61:608–610. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Perez Valero I, Cabello A, Ryan P, De La Fuente-Moral S, Santos I, Vivancos MJ, Gonzalez A, Gorgolas M, Cuevas G, Diaz De Santiago A, et al: Randomized trial evaluating the neurotoxicity of dolutegravir/abacavir/lamivudine and its reversibility after switching to elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide: GESIDA 9016. Open Forum Infect Dis. 7:ofaa4822020. View Article : Google Scholar : PubMed/NCBI

21 

Tarpey AE, Loranger A, Plambeck R and Malesker MA: Neurotoxicity secondary to valacyclovir. J Pharm Technol. 38:251–252. 2022. View Article : Google Scholar : PubMed/NCBI

22 

Vonberg FW, Dawson A, Scott G and Davies N: Aciclovir-induced neurotoxicity. Pract Neurol. 23:157–159. 2023. View Article : Google Scholar : PubMed/NCBI

23 

Garbiec E, Cielecka-Piontek J, Kowalowka M, Holubiec M and Zalewski P: Genistein-opportunities related to an interesting molecule of natural origin. Molecules. 27:8152022. View Article : Google Scholar : PubMed/NCBI

24 

Park JH, Hwang JW, Lee HJ, Jang GM, Jeong YJ, Cho J, Seo J and Hoe HS: Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation by modulating NLRP3, DYRK1A, and GSK3α/β. Front Immunol. 14:11509402023. View Article : Google Scholar : PubMed/NCBI

25 

Wei TT, Chandy M, Nishiga M, Zhang A, Kumar KK, Thomas D, Manhas A, Rhee S, Justesen JM, Chen IY, et al: Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation. Cell. 185:2387–2389.e23. 2022. View Article : Google Scholar : PubMed/NCBI

26 

Hannun YA and Obeid LM: Principles of bioactive lipid signalling: Lessons from sphingolipids. Nat Rev Mol Cell Biol. 9:139–150. 2008. View Article : Google Scholar : PubMed/NCBI

27 

van Meer G, Voelker DR and Feigenson GW: Membrane lipids: Where they are and how they behave. Nat Rev Mol Cell Biol. 9:112–124. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Dennis EA and Norris PC: Eicosanoid storm in infection and inflammation. Nat Rev Immunol. 15:511–523. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Brosnan JT: Interorgan amino acid transport and its regulation. J Nutr. 133 (6 Suppl 1):2068S–2072S. 2003. View Article : Google Scholar : PubMed/NCBI

30 

DeBerardinis RJ and Chandel NS: Fundamentals of cancer metabolism. Sci Adv. 2:e16002002016. View Article : Google Scholar : PubMed/NCBI

31 

Arlemalm A, Hellden A, Karlsson L and Carlsson B: Rapid determination of acyclovir, its main metabolite 9-carboxymethoxymethylguanine, ganciclovir, and penciclovir in human serum using LC-MS/MS. Biomed Chromatogr. 36:e53152022. View Article : Google Scholar : PubMed/NCBI

32 

Abuhelwa Z, Beran A, Venkataramany BS, Hinch BT and Assaly R: Concurrent nephrotoxicity and neurotoxicity induced by oral valacyclovir in a patient with previously normal kidney function. Cureus. 14:e236932022.PubMed/NCBI

33 

Aboelezz A and Mahmoud SH: Acyclovir dosing in herpes encephalitis: A scoping review. J Am Pharm Assoc (2003). 64:1020402024. View Article : Google Scholar : PubMed/NCBI

34 

Takeda S, Ueno S, Zenda R, Muto K, Iseki K and Harada K: Simultaneous analysis of acyclovir and its metabolite using hydrophilic interaction liquid chromatography-tandem mass spectrometry. J Anal Toxicol. 48:204–209. 2024. View Article : Google Scholar : PubMed/NCBI

35 

Leger PD, Johnson DH, Robbins GK, Shafer RW, Clifford DB, Li J, McLaren PJ and Haas DW: Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS clinical trials Group protocol 384. J Neurovirol. 20:304–308. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Bokore A, Korme B and Bayisa G: Determinants of anti-retroviral regimen changes among HIV/AIDS patients of east and west Wollega zone health institutions, Oromia region, west Ethiopia: A cross-sectional study. BMC Pharmacol Toxicol. 19:282018. View Article : Google Scholar : PubMed/NCBI

37 

Dalakas MC: Peripheral neuropathy and antiretroviral drugs. J Peripher Nerv Syst. 6:14–20. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Youle M: Acetyl-L-carnitine in HIV-associated antiretroviral toxic neuropathy. CNS Drugs. 21 (Suppl 1):25–30; discussion 45–26. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Dagan T, Sable C, Bray J and Gerschenson M: Mitochondrial dysfunction and antiretroviral nucleoside analog toxicities: What is the evidence? Mitochondrion. 1:397–412. 2002. View Article : Google Scholar : PubMed/NCBI

40 

Chantharakhit C and Sujaritvanichpong N: Predictive factors for the development of capecitabine-induced hand-foot syndrome: A retrospective observational cohort study. Ann Med Surg (Lond). 86:73–77. 2024. View Article : Google Scholar : PubMed/NCBI

41 

Yap YS, Kwok LL, Syn N, Chay WY, Chia JWK, Tham CK, Wong NS, Lo SK, Dent RA, Tan S, et al: Predictors of hand-foot syndrome and pyridoxine for prevention of capecitabine-induced hand-foot syndrome: A Randomized clinical trial. JAMA Oncol. 3:1538–1545. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Kwakman JJM, Simkens LHJ, van Rooijen JM, van de Wouw AJ, Ten Tije AJ, Creemers GJM, Hendriks MP, Los M, van Alphen RJ, Polee MB, et al: Randomized phase III trial of S-1 versus capecitabine in the first-line treatment of metastatic colorectal cancer: SALTO study by the Dutch colorectal cancer group. Ann Oncol. 28:1288–1293. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Santhosh A, Sharma A, Bakhshi S, Kumar A, Sharma V, Malik PS, Pramanik R, Gogia A, Prasad CP, Sehgal T, et al: Topical diclofenac for prevention of capecitabine-associated hand-foot syndrome: A double-blind randomized controlled trial. J Clin Oncol. 42:1821–1829. 2024. View Article : Google Scholar : PubMed/NCBI

44 

Lian S, Zhang X, Zhang Y and Zhao Q: Pyridoxine for prevention of hand-foot syndrome caused by chemotherapy agents: A meta-analysis. Clin Exp Dermatol. 46:629–635. 2021. View Article : Google Scholar : PubMed/NCBI

45 

Azuma Y, Hata K, Sai K, Udagawa R, Hirakawa A, Tohkin M, Ryushima Y, Makino Y, Yokote N, Morikawa N, et al: Significant association between hand-foot syndrome and efficacy of capecitabine in patients with metastatic breast cancer. Biol Pharm Bull. 35:717–724. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Chen M, Chen J, Peng X, Xu Z, Shao J, Zhu Y, Li G, Zhu H, Yang B, Luo P and He Q: The contribution of keratinocytes in capecitabine-stimulated hand-foot-syndrome. Environ Toxicol Pharmacol. 49:81–88. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Guengerich FP and MacDonald JS: Applying mechanisms of chemical toxicity to predict drug safety. Chem Res Toxicol. 20:344–369. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Park SY, Kim MW, Kang JH, Hwang JH, Choi H, Park J, Seong JK, Yoon YS and Oh SH: Loss of Ninjurin1 alleviates acetaminophen-induced liver injury via enhancing AMPKα-NRF2 pathway. Life Sci. 350:1227822024. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Bai Y, Chen H, Gu L, Shi B, Wang Z, Duanmu Y, Hu Y, Wang Y, Zhang C, Su Z, Su Z, et al: Identification of metabolites associated with capecitabine‑induced hand‑foot syndrome using untargeted metabolomics in patients with cancer. Mol Med Rep 32: 203, 2025.
APA
Bai, Y., Chen, H., Gu, L., Shi, B., Wang, Z., Duanmu, Y. ... Su, Z. (2025). Identification of metabolites associated with capecitabine‑induced hand‑foot syndrome using untargeted metabolomics in patients with cancer. Molecular Medicine Reports, 32, 203. https://doi.org/10.3892/mmr.2025.13568
MLA
Bai, Y., Chen, H., Gu, L., Shi, B., Wang, Z., Duanmu, Y., Hu, Y., Wang, Y., Zhang, C., Su, Z."Identification of metabolites associated with capecitabine‑induced hand‑foot syndrome using untargeted metabolomics in patients with cancer". Molecular Medicine Reports 32.1 (2025): 203.
Chicago
Bai, Y., Chen, H., Gu, L., Shi, B., Wang, Z., Duanmu, Y., Hu, Y., Wang, Y., Zhang, C., Su, Z."Identification of metabolites associated with capecitabine‑induced hand‑foot syndrome using untargeted metabolomics in patients with cancer". Molecular Medicine Reports 32, no. 1 (2025): 203. https://doi.org/10.3892/mmr.2025.13568
Copy and paste a formatted citation
x
Spandidos Publications style
Bai Y, Chen H, Gu L, Shi B, Wang Z, Duanmu Y, Hu Y, Wang Y, Zhang C, Su Z, Su Z, et al: Identification of metabolites associated with capecitabine‑induced hand‑foot syndrome using untargeted metabolomics in patients with cancer. Mol Med Rep 32: 203, 2025.
APA
Bai, Y., Chen, H., Gu, L., Shi, B., Wang, Z., Duanmu, Y. ... Su, Z. (2025). Identification of metabolites associated with capecitabine‑induced hand‑foot syndrome using untargeted metabolomics in patients with cancer. Molecular Medicine Reports, 32, 203. https://doi.org/10.3892/mmr.2025.13568
MLA
Bai, Y., Chen, H., Gu, L., Shi, B., Wang, Z., Duanmu, Y., Hu, Y., Wang, Y., Zhang, C., Su, Z."Identification of metabolites associated with capecitabine‑induced hand‑foot syndrome using untargeted metabolomics in patients with cancer". Molecular Medicine Reports 32.1 (2025): 203.
Chicago
Bai, Y., Chen, H., Gu, L., Shi, B., Wang, Z., Duanmu, Y., Hu, Y., Wang, Y., Zhang, C., Su, Z."Identification of metabolites associated with capecitabine‑induced hand‑foot syndrome using untargeted metabolomics in patients with cancer". Molecular Medicine Reports 32, no. 1 (2025): 203. https://doi.org/10.3892/mmr.2025.13568
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