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β‑elemene attenuates IRI‑AKI by inhibiting inflammation and apoptosis via suppression of the TLR4/MyD88/NF‑κB/MAPK signal axis activation

  • Authors:
    • Qiming Gong
    • Yakun Wang
    • Fahui Liu
    • Yuqing Huang
    • Luxin Li
    • Dongsheng Cheng
    • Shoujun Bai
    • Wenjuan Sun
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, P.R. China, Department of Nephrology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, P.R. China, Xiamen Cell Therapy Research Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361005, P.R. China, Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China, Department of Nephrology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai 201700, P.R. China, Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200003, P.R. China
    Copyright: © Gong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 221
    |
    Published online on: June 3, 2025
       https://doi.org/10.3892/mmr.2025.13586
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Abstract

Ischemia‑reperfusion injury‑induced acute kidney injury (IRI‑AKI) involves inflammatory cell infiltration and increased apoptosis, although the potential association between these processes remains unclear. The aim of the present study was to assess the impact of β‑elemene treatment on the IRI‑AKI using both in vivo and in vitro models, reverse transcription‑quantitative PCR, western blot assays, hematoxylin and Eosin (H&E) staining, Immunohistochemical staining and TUNEL staining. β‑elemene significantly decreased morphological and pathological kidney inflammation in mice caused by IRI. Additionally, β‑elemene prevented the expression of inflammatory factors and apoptosis proteins dose‑dependently in IRI mice and rat renal proximal tubule NRK52E cells treated with H2O2. Mechanistically, β‑elemene exerted its effects by inhibiting toll‑like receptor 4/myeloid differentiation primary response gene 88 (MyD88) signal activation and blocking NF‑κB/MAPK signal phosphorylation. Additionally, the increases in apoptosis and MAPK signal activation following hydrogen peroxide treatment were restored by MyD88 inhibition in NRK52E cells. The present study revealed that β‑elemene is a promising preclinical candidate for AKI.
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View References

1 

Waikar SS, Liu KD and Chertow GM: Diagnosis, epidemiology and outcomes of acute kidney injury. Clin J Am Soc Nephrol. 3:844–861. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Boratyńska M, Kamińska D and Mazanowska O: Pathophysiology of ischemia-reperfusion injury in renal transplantation. Postepy Hig Med Dosw (Online). 58:1–8. 2004.(In Polish). PubMed/NCBI

3 

Dong Y, Zhang Q, Wen J, Chen T, He L, Wang Y, Yin J, Wu R, Xue R, Li S, et al: Ischemic duration and frequency determines AKI-to-CKD progression monitored by dynamic changes of tubular biomarkers in IRI mice. Front Physiol. 10:1532019. View Article : Google Scholar : PubMed/NCBI

4 

Forbes JM, Hewitson TD, Becker GJ and Jones CL: Ischemic acute renal failure: Long-term histology of cell and matrix changes in the rat. Kidney Int. 57:2375–2385. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Sanz AB, Sanchez-Niño MD, Ramos AM and Ortiz A: Regulated cell death pathways in kidney disease. Nat Rev Nephrol. 19:281–299. 2023. View Article : Google Scholar : PubMed/NCBI

6 

Phaniendra A, Jestadi DB and Periyasamy L: Free radicals: Properties, sources, targets, and their implication in various diseases. Indian J Clin Biochem. 30:11–26. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Kim J, Seok YM, Jung KJ and Park KM: Reactive oxygen species/oxidative stress contributes to progression of kidney fibrosis following transient ischemic injury in mice. Am J Physiol Renal Physiol. 297:F461–F470. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Bonventre JV and Yang L: Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest. 121:4210–4221. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Zhao L, Hao Y, Tang S, Han X, Li R and Zhou X: Energy metabolic reprogramming regulates programmed cell death of renal tubular epithelial cells and might serve as a new therapeutic target for acute kidney injury. Front Cell Dev Biol. 11:12762172023. View Article : Google Scholar : PubMed/NCBI

10 

Gong S, Xiong H, Lei Y, Huang S, Ouyang Y, Cao C and Wang Y: Usp9× contributes to the development of sepsis-induced acute kidney injury by promoting inflammation and apoptosis in renal tubular epithelial cells via activation of the TLR4/nf-κb pathway. Ren Fail. 46:23610892024. View Article : Google Scholar : PubMed/NCBI

11 

Devarajan P: Update on mechanisms of ischemic acute kidney injury. J Am Soc Nephrol. 17:1503–1520. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Yang B, Lan S, Dieudé M, Sabo-Vatasescu JP, Karakeussian-Rimbaud A, Turgeon J, Qi S, Gunaratnam L, Patey N and Hébert MJ: Caspase-3 is a pivotal regulator of microvascular rarefaction and renal fibrosis after ischemia-reperfusion injury. J Am Soc Nephrol. 29:1900–1916. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Yang Q, Qian L and Zhang S: Ginsenoside Rh1 alleviates HK-2 apoptosis by inhibiting ROS and the JNK/p53 pathways. Evid Based Complement Alternat Med. 2020:34010672020. View Article : Google Scholar : PubMed/NCBI

14 

Wu L, Zhang R, Lin S, Lin M and Wang J: Silencing CDK6-AS1 inhibits LPS-induced inflammatory damage in HK-2 cells. Open Med (Wars). 16:1256–1264. 2021. View Article : Google Scholar : PubMed/NCBI

15 

Bai Z, Yao C, Zhu J, Xie Y, Ye XY, Bai R and Xie T: Anti-tumor drug discovery based on natural product β-Elemene: Anti-tumor mechanisms and structural modification. Molecules. 26:14492021. View Article : Google Scholar

16 

Zhu T, Xu Y, Dong B, Zhang J, Wei Z, Xu Y and Yao Y: β-elemene inhibits proliferation of human glioblastoma cells through the activation of glia maturation factor β and induces sensitization to cisplatin. Oncol Rep. 26:405–413. 2011.PubMed/NCBI

17 

Yu X, Li Z, Zhang Y, Xu M, Che Y, Tian X, Wang R, Zou K and Zou L: β-elemene inhibits radiation and hypoxia-induced macrophages infiltration via Prx-1/NF-κB/HIF-1α signaling pathway. Onco Targets Ther. 12:4203–4211. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Cai SZ, Xiong QW, Zhao L, Ji YT, Luo ZX and Ma ZR: β-elemene triggers ROS-dependent apoptosis in glioblastoma cells through suppressing STAT3 signaling pathway. Pathol Oncol Res. 27:5942992021. View Article : Google Scholar : PubMed/NCBI

19 

Sun W, Choi HS, Kim CS, Bae EH, Ma SK and Kim SW: Maslinic acid attenuates ischemia/reperfusion-induced acute kidney injury by suppressing inflammation and apoptosis through inhibiting NF-κB and MAPK signaling pathway. Front Pharmacol. 13:8074522022. View Article : Google Scholar : PubMed/NCBI

20 

Wei Q and Dong Z: Mouse model of ischemic acute kidney injury: Technical notes and tricks. Am J Physiol Renal Physiol. 303:F1487–F1494. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Basile DP, Bonventre JV, Mehta R, Nangaku M, Unwin R, Rosner MH, Kellum JA and Ronco C; ADQI XIII Work Group, : ADQI XIII work group. Progression after AKI: Understanding maladaptive repair processes to predict and identify therapeutic treatments. J Am Soc Nephrol. 27:687–697. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Sun W, Kim DH, Byon CH, Choi HI, Park JS, Bae EH, Ma SK and Kim SW: β-Elemene attenuates renal fibrosis in the unilateral ureteral obstruction model by inhibition of STAT3 and Smad3 signaling via suppressing MyD88 expression. Int J Mol Sci. 23:55532022. View Article : Google Scholar : PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Tak PP and Firestein GS: NF-kappaB: A key role in inflammatory diseases. J Clin Invest. 107:7–11. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Havasi A and Borkan SC: Apoptosis and acute kidney injury. Kidney Int. 80:29–40. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Meng F, Chen Q, Gu S, Cui R, Ma Q, Cao R and Zhao M: Inhibition of Circ-Snrk ameliorates apoptosis and inflammation in acute kidney injury by regulating the MAPK pathway. Ren Fail. 44:672–681. 2022. View Article : Google Scholar : PubMed/NCBI

27 

Kyriakis JM and Avruch J: Mammalian MAPK signal transduction pathways activated by stress and inflammation: A 10-year update. Physiol Rev. 92:689–737. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Kwon O, Hong SM, Sutton TA and Temm CJ: Preservation of peritubular capillary endothelial integrity and increasing pericytes may be critical to recovery from postischemic acute kidney injury. Am J Physiol Renal Physiol. 295:F351–F359. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Zheng Q, Xing J, Li X, Tang X and Zhang D: PRDM16 suppresses ferroptosis to protect against sepsis-associated acute kidney injury by targeting the NRF2/GPX4 axis. Redox Biol. 78:1034172024. View Article : Google Scholar : PubMed/NCBI

30 

Li X, Yuan F, Xiong Y, Tang Y, Li Z, Ai J, Miao J, Ye W, Zhou S, Wu Q, et al: FAM3A plays a key role in protecting against tubular cell pyroptosis and acute kidney injury. Redox Biol. 74:1032252024. View Article : Google Scholar : PubMed/NCBI

31 

Linkermann A, Chen G, Dong G, Kunzendorf U, Krautwald S and Dong Z: Regulated cell death in AKI. J Am Soc Nephrol. 25:2689–2701. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Fang Y, Kang Y, Zou H, Cheng X, Xie T, Shi L and Zhang H: β-elemene attenuates macrophage activation and proinflammatory factor production via crosstalk with Wnt/β-catenin signaling pathway. Fitoterapia. 124:92–102. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Zhao Q, Chen L, Zhang X, Yang H, Li Y and Li P: β-elemene promotes microglial M2-like polarization against ischemic stroke via AKT/mTOR signaling axis-mediated autophagy. Chin Med. 19:862024. View Article : Google Scholar : PubMed/NCBI

34 

Zhang G, Xue C and Zeng Y: β-elemene alleviates airway stenosis via the ILK/Akt pathway modulated by MIR143HG sponging miR-1275. Cell Mol Biol Lett. 26:282021. View Article : Google Scholar : PubMed/NCBI

35 

Zhai B, Wu Q, Wang W, Zhang M, Han X, Li Q, Chen P, Chen X, Huang X, Li G, et al: Preparation, characterization, pharmacokinetics and anticancer effects of PEGylated β-elemene liposomes. Cancer Biol Med. 17:60–75. 2020. View Article : Google Scholar : PubMed/NCBI

36 

Gan D, He W, Yin H and Gou X: β-elemene enhances cisplatin-induced apoptosis in bladder cancer cells through the ROS-AMPK signaling pathway. Oncol Lett. 19:291–300. 2020.PubMed/NCBI

37 

Lee RX, Li QQ and Reed E: β-elemene effectively suppresses the growth and survival of both platinum-sensitive and -resistant ovarian tumor cells. Anticancer Res. 32:3103–3113. 2012.PubMed/NCBI

38 

Zhou Y, Takano T, Wang Y, Li X, Wang R, Wakatsuki Y, Nakajima-Adachi H, Tanokura M, Miyakawa T and Hachimura S: Intestinal regulatory T cell induction by β-elemene alleviates the formation of fat tissue-related inflammation. iScience. 24:1018832021. View Article : Google Scholar : PubMed/NCBI

39 

Eltzschig HK and Collard CD: Vascular ischaemia and reperfusion injury. Br Med Bull. 70:71–86. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Ramesh G and Reeves WB: Inflammatory cytokines in acute renal failure. Kidney Int Suppl. 91:S56–S61. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Delneste Y, Beauvillain C and Jeannin P: Innate immunity: Structure and function of TLRs. Med Sci (Paris). 23:67–73. 2007.(In French). View Article : Google Scholar : PubMed/NCBI

42 

Chen J, Hartono JR, John R, Bennett M, Zhou XJ, Wang Y, Wu Q, Winterberg PD, Nagami GT and Lu CY: Early interleukin 6 production by leukocytes during ischemic acute kidney injury is regulated by TLR4. Kidney Int. 80:504–515. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Wu H, Chen G, Wyburn KR, Yin J, Bertolino P, Eris JM, Alexander SI, Sharland AF and Chadban SJ: TLR4 activation mediates kidney ischemia/reperfusion injury. J Clin Invest. 117:2847–2859. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Zhang LM, Liu JH, Xue CB, Li MQ, Xing S, Zhang X, He WT, Jiang FC, Lu X and Zhou P: Pharmacological inhibition of MyD88 homodimerization counteracts renal ischemia reperfusion-induced progressive renal injury in vivo and in vitro. Sci Rep. 6:269542016. View Article : Google Scholar : PubMed/NCBI

45 

Basnakian AG, Kaushal GP and Shah SV: Apoptotic pathways of oxidative damage to renal tubular epithelial cells. Antioxid Redox Signal. 4:915–924. 2002. View Article : Google Scholar : PubMed/NCBI

46 

Kaushal GP, Basnakian AG and Shah SV: Apoptotic pathways in ischemic acute renal failure. Kidney Int. 66:500–506. 2004. View Article : Google Scholar : PubMed/NCBI

47 

Zhang H and Sun SC: NF-κB in inflammation and renal diseases. Cell Biosci. 5:632015. View Article : Google Scholar : PubMed/NCBI

48 

Oberbauer R, Schwarz C, Regele HM, Hansmann C, Meyer TW and Mayer G: Regulation of renal tubular cell apoptosis and proliferation after ischemic injury to a solitary kidney. J Lab Clin Med. 138:343–351. 2001. View Article : Google Scholar : PubMed/NCBI

49 

Zou G, Zhou Z, Xi X, Huang R and Hu H: Pioglitazone ameliorates renal ischemia-reperfusion injury via inhibition of NF-κB activation and inflammation in rats. Front Physiol. 12:7073442021. View Article : Google Scholar : PubMed/NCBI

50 

Sun W, Byon CH, Kim DH, Choi HI, Park JS, Joo SY, Kim IJ, Jung I, Bae EH, Ma SK and Kim SW: Renoprotective effects of maslinic acid on experimental renal fibrosis in unilateral ureteral obstruction model via targeting MyD88. Front Pharmacol. 12:7085752021. View Article : Google Scholar : PubMed/NCBI

51 

Li X, Huang R, Liu K, Li M, Luo H, Cui L, Huang L and Luo L: Fucoxanthin attenuates LPS-induced acute lung injury via inhibition of the TLR4/MyD88 signaling axis. Aging (Albany NY). 13:2655–2667. 2020. View Article : Google Scholar : PubMed/NCBI

52 

Cargnello M and Roux PP: Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev. 75:50–83. 2011. View Article : Google Scholar : PubMed/NCBI

53 

Cuarental L, Sucunza-Sáenz D, Valiño-Rivas L, Fernandez-Fernandez B, Sanz AB, Ortiz A, Vaquero JJ and Sanchez-Niño MD: MAP3K kinases and kidney injury. Nefrologia (Engl Ed). 39:568–580. 2019. View Article : Google Scholar : PubMed/NCBI

54 

Chu W, Li M, Li F, Hu R, Chen Z, Lin J and Feng H: Immediate splenectomy down-regulates the MAPK-NF-κB signaling pathway in rat brain after severe traumatic brain injury. J Trauma Acute Care Surg. 74:1446–1453. 2013. View Article : Google Scholar : PubMed/NCBI

55 

Guo X, Jiang H, Chen J, Zhang BF, Hu Q, Yang S, Yang J and Zhang J: RP105 ameliorates hypoxia/reoxygenation injury in cardiac microvascular endothelial cells by suppressing TLR4/MAPKs/NF-κB signaling. Int J Mol Med. 42:505–513. 2018.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gong Q, Wang Y, Liu F, Huang Y, Li L, Cheng D, Bai S and Sun W: β‑elemene attenuates IRI‑AKI by inhibiting inflammation and apoptosis via suppression of the TLR4/MyD88/NF‑κB/MAPK signal axis activation. Mol Med Rep 32: 221, 2025.
APA
Gong, Q., Wang, Y., Liu, F., Huang, Y., Li, L., Cheng, D. ... Sun, W. (2025). β‑elemene attenuates IRI‑AKI by inhibiting inflammation and apoptosis via suppression of the TLR4/MyD88/NF‑κB/MAPK signal axis activation. Molecular Medicine Reports, 32, 221. https://doi.org/10.3892/mmr.2025.13586
MLA
Gong, Q., Wang, Y., Liu, F., Huang, Y., Li, L., Cheng, D., Bai, S., Sun, W."β‑elemene attenuates IRI‑AKI by inhibiting inflammation and apoptosis via suppression of the TLR4/MyD88/NF‑κB/MAPK signal axis activation". Molecular Medicine Reports 32.2 (2025): 221.
Chicago
Gong, Q., Wang, Y., Liu, F., Huang, Y., Li, L., Cheng, D., Bai, S., Sun, W."β‑elemene attenuates IRI‑AKI by inhibiting inflammation and apoptosis via suppression of the TLR4/MyD88/NF‑κB/MAPK signal axis activation". Molecular Medicine Reports 32, no. 2 (2025): 221. https://doi.org/10.3892/mmr.2025.13586
Copy and paste a formatted citation
x
Spandidos Publications style
Gong Q, Wang Y, Liu F, Huang Y, Li L, Cheng D, Bai S and Sun W: β‑elemene attenuates IRI‑AKI by inhibiting inflammation and apoptosis via suppression of the TLR4/MyD88/NF‑κB/MAPK signal axis activation. Mol Med Rep 32: 221, 2025.
APA
Gong, Q., Wang, Y., Liu, F., Huang, Y., Li, L., Cheng, D. ... Sun, W. (2025). β‑elemene attenuates IRI‑AKI by inhibiting inflammation and apoptosis via suppression of the TLR4/MyD88/NF‑κB/MAPK signal axis activation. Molecular Medicine Reports, 32, 221. https://doi.org/10.3892/mmr.2025.13586
MLA
Gong, Q., Wang, Y., Liu, F., Huang, Y., Li, L., Cheng, D., Bai, S., Sun, W."β‑elemene attenuates IRI‑AKI by inhibiting inflammation and apoptosis via suppression of the TLR4/MyD88/NF‑κB/MAPK signal axis activation". Molecular Medicine Reports 32.2 (2025): 221.
Chicago
Gong, Q., Wang, Y., Liu, F., Huang, Y., Li, L., Cheng, D., Bai, S., Sun, W."β‑elemene attenuates IRI‑AKI by inhibiting inflammation and apoptosis via suppression of the TLR4/MyD88/NF‑κB/MAPK signal axis activation". Molecular Medicine Reports 32, no. 2 (2025): 221. https://doi.org/10.3892/mmr.2025.13586
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