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![Cell proliferation curve and DNA
fragmentation analysis. (A) Cumulative proliferation of Wt-HL60 and
Res-HL60 cells under non-irradiated conditions. Cells were seeded
at 2×105 cells/ml on Day-1 and cultured without
irradiation. On Day 2, the cells were passaged to maintain the same
seeding density. If cell density remained below this threshold,
only the medium was replaced without passaging. The cumulative
number of viable cells was calculated using the formula: Cumulative
cell number (/ml)=A × [(2×105) + B]/(2×105),
where ‘A’ is the viable cell number up to Day 2, and ‘B’ is the net
increase from Day 3 onward relative to the reseeding density. (B)
Cumulative proliferation of Wt-HL60 and Res-HL60 cells under 4-Gy
irradiated conditions. The same seeding and passaging protocol as
in (A) was followed, except that the cells were exposed to 4 Gy of
X-ray irradiation on Day 0. Cell proliferation was then monitored
to assess the impact of irradiation on the growth of wild-type and
resistant HL60 cells. Cumulative viable cell numbers were
calculated using the same formula as in (A). (C) Representative
images of the comet assay showing DNA damage 24 h after X-ray
exposure at doses of 1–4 Gy. (D) Quantification of DNA damage based
on tail moment calculated from the comet assay shown in (C). Data
are shown as the mean ± standard error of the mean from four
independent experiments. *P<0.05, **P<0.01 vs. Wt-HL60,
determined by unpaired Student's t-test. Wt, wild type; Res,
resistant.](/article_images/mmr/32/4/mmr-32-04-13645-g01.jpg)
