Runx3 expression in lymph nodes with metastasis is associated with the outcome of gastric cancer patients

  • Authors:
    • Hong-Wei Xu
    • Feng Ren
    • Yan-Ming Yu
    • Cheng-Zhong Cai
  • View Affiliations

  • Published online on: August 11, 2011     https://doi.org/10.3892/ol.2011.381
  • Pages: 1275-1279
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Accumulating evidence shows that runt-related transcription factor 3 (Runx3) is a putative tumor suppressor in various types of cancer, the lower levels of which are associated with a less favorable cancer outcome. However, these studies were restricted to primary cancer lesions. Lymph node metastasis (LNM) is a significant factor in determining the prognosis of patients with gastric cancer and is a frequent target of chemotherapy. In the present study, we investigated the expression of Runx3 in the lymph nodes (LNs) of stomach carcinoma and the association of Runx3 expression with the prognosis of patients. The expression of Runx3 in LNs with and without metastasis was detected by reverse transcriptase‑polymerase chain reaction (RT-PCR) and Western blotting. The positive rate of Runx3 mRNA in LNM specimens was significantly lower (28.4%, 21 out of 74) compared to that of the non‑metastatic samples (33.3%, 9 out of 27, P<0.05). Similar findings were obtained by Western blotting. Univariate analysis revealed that the loss of Runx3 expression in LNs was not only associated with poor clinicopathological factors, such as LNM, distant organ metastasis, later clinicopathological stages and deep infiltration, but also with a lower 5-year survival rate and poorer prognosis. These results strongly suggest a potential diagnostic value of Runx3 expression in LNs and multiple pathways contributing to the outcome of patients with gastric cancer.
View Figures
View References

Related Articles

Journal Cover

November-December 2011
Volume 2 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Xu H, Ren F, Yu Y and Cai C: Runx3 expression in lymph nodes with metastasis is associated with the outcome of gastric cancer patients. Oncol Lett 2: 1275-1279, 2011
APA
Xu, H., Ren, F., Yu, Y., & Cai, C. (2011). Runx3 expression in lymph nodes with metastasis is associated with the outcome of gastric cancer patients. Oncology Letters, 2, 1275-1279. https://doi.org/10.3892/ol.2011.381
MLA
Xu, H., Ren, F., Yu, Y., Cai, C."Runx3 expression in lymph nodes with metastasis is associated with the outcome of gastric cancer patients". Oncology Letters 2.6 (2011): 1275-1279.
Chicago
Xu, H., Ren, F., Yu, Y., Cai, C."Runx3 expression in lymph nodes with metastasis is associated with the outcome of gastric cancer patients". Oncology Letters 2, no. 6 (2011): 1275-1279. https://doi.org/10.3892/ol.2011.381