Comparative expression of matrix metalloproteinases in low‑grade mucoepidermoid carcinoma and typical lung cancer

Fan,Jiang; Wu,Feng-Ying; Wang,Lei; Jiang,Ge-Ning; Gao,Wen

doi:10.3892/ol.2011.387

Comparative expression of matrix metalloproteinases in low‑grade mucoepidermoid carcinoma and typical lung cancer

Authors:
- Jiang Fan
- Feng-Ying Wu
- Lei Wang
- Ge-Ning Jiang
- Wen Gao
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Affiliations: Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Shanghai 200433, P.R. China, Department of Medical Oncology, Shanghai Pulmonary Hospital, Shanghai 200433, P.R. China, Department of Surgical Oncology, Shandong Tumor Hospital, Shandong Academy of Medical Science, Shandong 250062, P.R. China
Published online on: August 18, 2011 https://doi.org/10.3892/ol.2011.387
Pages: 1269-1273

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Abstract

The molecular profile of low‑grade mucoepidermoid carcinomas remains to be clarified. In the present study, matrix metalloproteinase (MMP) expression was compared in low‑grade mucoepidermoid carcinoma (MEC) and typical lung cancer. The expression of MMP‑2, MMP-7 and MMP-9 was detected by immunohistochemistry in a cohort of 110 patients (34 with low‑grade MEC and 76 with matched typical lung cancers). A positive MMP‑2 expression was found to be 35.29 vs. 65.79% in low‑grade MEC and typical NSCLCs (p=0.003); a positive MMP‑7 expression was 41.18 vs. 55.26% (p=0.172); and a positive MMP‑9 expression was 35.29 vs. 57.89% (p=0.028). In conclusion, the expression of MMP‑2 and MMP-9 in low‑grade MEC is lower than that in typical lung carcinomas.

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1	Molina JR, Aubry MC, Lewis JE, et al: Primary salivary gland-type lung cancer: spectrum of clinical presentation, histopathologic and prognostic factors. Cancer. 110:2253–2259. 2007. View Article : Google Scholar : PubMed/NCBI
2	Heitmiller RF, Mathisen DJ, Ferry JA, Mark EJ and Grillo HC: Mucoepidermoid lung tumors. Ann Thorac Surg. 47:394–399. 1989. View Article : Google Scholar : PubMed/NCBI
3	Chin CH, Huang CC, Lin MC, Chao TY and Liu SF: Prognostic factors of tracheobronchial mucoepidermoid carcinoma–15 years experience. Respirology. 13:275–280. 2008.
4	Yang KY, Chen YM, Huang MH and Perng RP: Revisit of primary malignant neoplasms of the trachea: clinical characteristics and survival analysis. Jpn J Clin Oncol. 27:305–309. 1997. View Article : Google Scholar : PubMed/NCBI
5	Lal DR, Clark I, Shalkow J, et al: Primary epithelial lung malignancies in the pediatric population. Pediatr Blood Cancer. 45:683–686. 2005. View Article : Google Scholar : PubMed/NCBI
6	Torres AM and Ryckman FC: Childhood tracheobronchial mucoepidermoid carcinoma: a case report and review of the literature. J Pediatr Surg. 23:367–370. 1988. View Article : Google Scholar : PubMed/NCBI
7	Passlick B, Sienel W, Seen-Hibler R, et al: Overexpression of matrix metalloproteinase 2 predicts unfavorable outcome in early-stage non-small cell lung cancer. Clin Cancer Res. 6:3944–3948. 2000.PubMed/NCBI
8	Gonzalez N, Rodriguez N, Tripari J, et al: RT-PCR comparative study of viral load levels in the HIV positive population in Puerto Rico before and after protease inhibitor regimen implanted. Bol Asoc Med P R. 90:16–20. 1998.
9	Kodate M, Kasai T, Hashimoto H, Yasumoto K, Iwata Y and Manabe H: Expression of matrix metalloproteinase (gelatinase) in T1 adenocarcinoma of the lung. Pathol Int. 47:461–469. 1997. View Article : Google Scholar : PubMed/NCBI
10	Brown PD, Bloxidge RE, Stuart NS, Gatter KC and Carmichael J: Association between expression of activated 72-kilodalton gelatinase and tumor spread in non-small-cell lung carcinoma. J Natl Cancer Inst. 85:574–578. 1993. View Article : Google Scholar : PubMed/NCBI
11	Yousem SA and Hochholzer L: Mucoepidermoid tumors of the lung. Cancer. 60:1346–1352. 1987. View Article : Google Scholar : PubMed/NCBI
12	Moran CA, Suster S and Koss MN: Primary adenoid cystic carcinoma of the lung. A clinicopathologic and immunohistochemical study of 16 cases. Cancer. 73:1390–1397. 1994. View Article : Google Scholar : PubMed/NCBI
13	Minna JD, Roth JA and Gazdar AF: Focus on lung cancer. Cancer Cell. 1:49–52. 2002. View Article : Google Scholar
14	Hoikkala S, Paakko P, Soini Y, Makitaro R, Kinnula V and Turpeenniemi-Hujanen T: Tissue MMP-2 and MMP-9 are better prognostic factors than serum MMP-2/TIMP-2-complex or TIMP-1 in stage I–III lung carcinoma. Cancer Lett. 236:125–132. 2006.PubMed/NCBI
15	Turnbull AD, Huvos AG, Goodner JT and Foote FW Jr: Mucoepidermoid tumors of bronchial glands. Cancer. 28:539–544. 1971. View Article : Google Scholar : PubMed/NCBI
16	Chambers AF and Matrisian LM: Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst. 89:1260–1270. 1997. View Article : Google Scholar : PubMed/NCBI
17	Westermarck J and Kahari VM: Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J. 13:781–792. 1999.PubMed/NCBI
18	Sienel W, Hellers J, Morresi-Hauf A, et al: Prognostic impact of matrix metalloproteinase-9 in operable non-small cell lung cancer. Int J Cancer. 103:647–651. 2003. View Article : Google Scholar : PubMed/NCBI