Comparative expression of matrix metalloproteinases in low‑grade mucoepidermoid carcinoma and typical lung cancer

Fan,Jiang; Wu,Feng-Ying; Wang,Lei; Jiang,Ge-Ning; Gao,Wen

doi:10.3892/ol.2011.387

November-December 2011 Volume 2 Issue 6

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November-December 2011 Volume 2 Issue 6

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Article

Comparative expression of matrix metalloproteinases in low‑grade mucoepidermoid carcinoma and typical lung cancer

Authors:
- Jiang Fan
- Feng-Ying Wu
- Lei Wang
- Ge-Ning Jiang
- Wen Gao
View Affiliations / Copyright

Affiliations: Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Shanghai 200433, P.R. China, Department of Medical Oncology, Shanghai Pulmonary Hospital, Shanghai 200433, P.R. China, Department of Surgical Oncology, Shandong Tumor Hospital, Shandong Academy of Medical Science, Shandong 250062, P.R. China
Pages: 1269-1273
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Published online on: August 18, 2011

https://doi.org/10.3892/ol.2011.387
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Abstract

The molecular profile of low‑grade mucoepidermoid carcinomas remains to be clarified. In the present study, matrix metalloproteinase (MMP) expression was compared in low‑grade mucoepidermoid carcinoma (MEC) and typical lung cancer. The expression of MMP‑2, MMP-7 and MMP-9 was detected by immunohistochemistry in a cohort of 110 patients (34 with low‑grade MEC and 76 with matched typical lung cancers). A positive MMP‑2 expression was found to be 35.29 vs. 65.79% in low‑grade MEC and typical NSCLCs (p=0.003); a positive MMP‑7 expression was 41.18 vs. 55.26% (p=0.172); and a positive MMP‑9 expression was 35.29 vs. 57.89% (p=0.028). In conclusion, the expression of MMP‑2 and MMP-9 in low‑grade MEC is lower than that in typical lung carcinomas.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Comparative expression of matrix metalloproteinases in low‑grade mucoepidermoid carcinoma and typical lung cancer

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Abstract

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