|
1
|
Lu KP, Hanes SD and Hunter T: A human
peptidyl-prolyl isomerase essential for regulation of mitosis.
Nature. 380:544–547. 1996. View
Article : Google Scholar : PubMed/NCBI
|
|
2
|
Ranganathan R, Lu KP, Hunter T and Noel
JP: Structural and functional analysis of the mitotic rotamase Pin1
suggests substrate recognition is phosphorylation dependent. Cell.
89:875–886. 1997. View Article : Google Scholar
|
|
3
|
Lu KP: Pinning down cell signaling, cancer
and Alzheimer's disease. Trends Biochem Sci. 29:200–209. 2004.
View Article : Google Scholar
|
|
4
|
Zhou XZ, Lu PJ, Wulf G and Lu KP:
Phosphorylation-dependent prolyl isomerization: a novel signaling
regulatory mechanism. Cell Mol Life Sci. 56:788–806. 1999.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Kim MR, Choi HS, Heo TH, Hwang SW and Kang
KW: Induction of vascular endothelial growth factor by
peptidyl-prolyl isomerase Pin1 in breast cancer cells. Biochem
Biophys Res Commun. 369:547–553. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Ryo A, Liou YC, Wulf G, Nakamura M, Lee SW
and Lu KP: PIN1 is an E2F target gene essential for Neu/Ras-induced
transformation of mammary epithelial cells. Mol Cell Biol.
22:5281–5295. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Lu KP, Liou YC and Zhou XZ: Pinning down
proline-directed phosphorylation signaling. Trends Cell Biol.
12:164–172. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Wulf GM, Ryo A, Wulf GG, et al: Pin1 is
overexpressed in breast cancer and cooperates with Ras signaling in
increasing the transcriptional activity of c-Jun towards cyclin D1.
EMBO J. 20:3459–3472. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Bao L, Kimzey A, Sauter G, Sowadski JM, Lu
KP and Wang DG: Prevalent overexpression of prolyl isomerase Pin1
in human cancers. Am J Pathol. 164:1727–1737. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Ayala G, Wang D, Wulf G, et al: The prolyl
isomerase Pin1 is a novel prognostic marker in human prostate
cancer. Cancer Res. 63:6244–6251. 2003.PubMed/NCBI
|
|
11
|
He J, Zhou F, Shao K, et al:
Overexpression of Pin1 in non-small cell lung cancer (NSCLC) and
its correlation with lymph node metastases. Lung Cancer. 56:51–58.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Lu KP: Prolyl isomerase Pin1 as a
molecular target for cancer diagnostics and therapeutics. Cancer
Cell. 4:175–180. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Wulf G, Garg P, Liou YC, Iglehart D and Lu
KP: Modeling breast cancer in vivo and ex vivo reveals an essential
role of Pin1 in tumorigenesis. EMBO J. 23:3397–3407. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Lim J and Lu KP: Pinning down
phosphorylated tau and tauopathies. Biochim Biophys Acta.
1739:311–322. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Brondani V, Schefer Q, Hamy F and Klimkait
T: The peptidyl-prolyl isomerase Pin1 regulates phospho-Ser77
retinoic acid receptor alpha stability. Biochem Biophys Res Commun.
328:6–13. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Liou YC, Ryo A, Huang HK, et al: Loss of
Pin1 function in the mouse causes phenotypes resembling cyclin
D1-null phenotypes. Proc Natl Acad Sci USA. 99:1335–1340. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Liou YC, Sun A, Ryo A, et al: Role of the
prolyl isomerase Pin1 in protecting against age-dependent
neurodegeneration. Nature. 424:556–561. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Balastik M, Lim J, Pastorino L and Lu KP:
Pin1 in Alzheimer's disease: multiple substrates, one regulatory
mechanism? Biochim Biophys Acta. 1772:422–429. 2007.
|
|
19
|
Bulavin DV, Saito S, Hollander MC, et al:
Phosphorylation of human p53 by p38 kinase coordinates N-terminal
phosphorylation and apoptosis in response to UV radiation. EMBO J.
18:6845–6854. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Buschmann T, Potapova O, Bar-Shira A, et
al: Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is
important for p53 stabilization and transcriptional activities in
response to stress. Mol Cell Biol. 21:2743–2754. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Radhakrishnan SK and Gartel AL: CDK9
phosphorylates p53 on serine residues 33, 315 and 392. Cell Cycle.
5:519–521. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
D'Orazi G, Cecchinelli B, Bruno T, et al:
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser
46 and mediates apoptosis. Nat Cell Biol. 4:11–19. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Kurihara A, Nagoshi H, Yabuki M, Okuyama
R, Obinata M and Ikawa S: Ser46 phosphorylation of p53 is not
always sufficient to induce apoptosis: multiple mechanisms of
regulation of p53-dependent apoptosis. Genes Cells. 12:853–861.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Wulf GM, Liou YC, Ryo A, Lee SW and Lu KP:
Role of Pin1 in the regulation of p53 stability and p21
transactivation, and cell cycle checkpoints in response to DNA
damage. J Biol Chem. 277:47976–47979. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Ryo A, Liou YC, Lu KP and Wulf G: Prolyl
isomerase Pin1: a catalyst for oncogenesis and a potential
therapeutic target in cancer. J Cell Sci. 116:773–783. 2003.
View Article : Google Scholar : PubMed/NCBI
|
