Updates on the cytogenetics and molecular cytogenetics of benign and intermediate soft tissue tumors (Review)

  • Authors:
    • Jun Nishio
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  • Published online on: October 30, 2012     https://doi.org/10.3892/ol.2012.1002
  • Pages: 12-18
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Abstract

Soft tissue tumors are classified according to their histological resemblance to normal adult tissues and can be grouped into the following categories based on metastatic potential: benign, intermediate (locally aggressive), intermediate (rarely metastasizing) and malignant. Over the past two decades, considerable progress has been made in our understanding of the genetic background of soft tissue tumors. Traditional laboratory techniques, such as cytogenetic analysis and fluorescence in situ hybridization (FISH), can be used for diagnostic purposes in soft tissue pathology practice. Moreover, cytogenetic and molecular studies are often necessary for prognostics and follow‑up of soft tissue sarcoma patients. This review provides updated information on the applicability of laboratory genetic testing in the diagnosis of benign and intermediate soft tissue tumors. These tumors include nodular fasciitis, chondroid lipoma, collagenous fibroma (desmoplastic fibroblastoma), giant cell tumor of tendon sheath (GCTTS)/pigmented villonodular synovitis (PVNS), angiofibroma of soft tissue, myxoinflammatory fibroblastic sarcoma (MIFS) and ossifying fibromyxoid tumor (OFMT).
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January 2013
Volume 5 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Nishio J: Updates on the cytogenetics and molecular cytogenetics of benign and intermediate soft tissue tumors (Review). Oncol Lett 5: 12-18, 2013
APA
Nishio, J. (2013). Updates on the cytogenetics and molecular cytogenetics of benign and intermediate soft tissue tumors (Review). Oncology Letters, 5, 12-18. https://doi.org/10.3892/ol.2012.1002
MLA
Nishio, J."Updates on the cytogenetics and molecular cytogenetics of benign and intermediate soft tissue tumors (Review)". Oncology Letters 5.1 (2013): 12-18.
Chicago
Nishio, J."Updates on the cytogenetics and molecular cytogenetics of benign and intermediate soft tissue tumors (Review)". Oncology Letters 5, no. 1 (2013): 12-18. https://doi.org/10.3892/ol.2012.1002