Mesenchymal stem-like cells isolated from human esophageal carcinoma and adjacent non-cancerous tissues

Hu,Jiabo; Zhou,Zhongwei; Shi,Shunbin; Zhu,Xiaozhong; Wang,Xiaohui; Zhang,Wei; Hu,Sanqiang; Qian,Hui; Xu,Wenrong

doi:10.3892/ol.2012.1003

Mesenchymal stem-like cells isolated from human esophageal carcinoma and adjacent non-cancerous tissues

Authors:
- Jiabo Hu
- Zhongwei Zhou
- Shunbin Shi
- Xiaozhong Zhu
- Xiaohui Wang
- Wei Zhang
- Sanqiang Hu
- Hui Qian
- Wenrong Xu
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Affiliations: School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China, Department of Thoracic Surgery, the Affiliated Hospital of the Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China
Published online on: October 30, 2012 https://doi.org/10.3892/ol.2012.1003
Pages: 179-184

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Abstract

Mesenchymal stem cells (MSCs) or MSC-like cells have now been isolated from various sites, including different types of tumor tissues. Whether MSCs or MSC-like cells in different tumor tissues possess differentiated biological characteristics remains unclear, and the correlation between MSCs or MSC-like cells and tumors has been a controversial topic. In the present study, we isolated MSC-like cells from human esophageal carcinoma (hEC-MSCs) and adjacent non‑cancerous tissues (hECN-MSCs). Although the two types of MSC-like cells were in different microenvironments and had certain differences, they possessed similar morphological properties and surface antigens, including CD13, CD29, CD44 and CD105. Our results indicated that hEC-MSCs and hECN-MSCs are similar in a number of ways. This may have implications for further research on the esophageal carcinoma microenvironment and its pathological mechanism.

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