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Article

Factors influencing the risk of recurrence in patients with esophageal carcinoma treated with surgery: A single institution analysis consisting of 1002 cases

  • Authors:
    • Yaping Xu
    • Qixun Chen
    • Xinmin Yu
    • Ximing Zhou
    • Xiao Zheng
    • Weimin Mao
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang, P.R. China, Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang, P.R. China, Department of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang, P.R. China
  • Pages: 185-190
    |
    Published online on: October 30, 2012
       https://doi.org/10.3892/ol.2012.1007
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Abstract

The aim of this study was to identify the risk of recurrence in patients with thoracic esophageal squamous cell carcinoma (TESCC) treated with curative surgery. The retrospective analysis included 1002 consecutive patients with TESCC who had been treated with curative surgery in Zhejiang Cancer Hospital, China, between 2003 and 2008. Univariate and multivariate analyses using the Kaplan-Meier method and Cox proportional hazards model, respectively, were performed to identify the independent risk factors for locoregional recurrence and all the recurrence events. The 2- and 5-year recurrence rates were 39.0 and 59.2%, respectively. More than 85% of recurrences occurred within 36 months. The variables associated with a higher rate of recurrence in the univariate analysis were gender (male), length of tumor (≥5 cm), depth of invasion (deeper), lymph node metastasis (greater), histological grade (higher) and vessel involvement (positive). By multivariate analyses, gender (HR, 1.7; 95% CI, 1.2‑2.5; P=0.002), depth of invasion (HR, 1.4; 95% CI, 1.2‑1.6; P<0.001) and lymph node involvement (HR, 1.4; 95% CI, 1.3‑1.5; P<0.001) were independent predictive factors of recurrence. Post-operative radiotherapy or chemotherapy did not significantly prolong failure-free survival (FFS), particularly in patients with early-stage disease. Information regarding the depth of primary tumor invasion and the number of lymph nodes involved may help in evaluating the recurrence risk in patients with TESCC treated with curative surgery. Further studies are required to clarify the correlation between recurrence and the different multidisciplinary treatment approaches.
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Copy and paste a formatted citation
Spandidos Publications style
Xu Y, Chen Q, Yu X, Zhou X, Zheng X and Mao W: Factors influencing the risk of recurrence in patients with esophageal carcinoma treated with surgery: A single institution analysis consisting of 1002 cases. Oncol Lett 5: 185-190, 2013.
APA
Xu, Y., Chen, Q., Yu, X., Zhou, X., Zheng, X., & Mao, W. (2013). Factors influencing the risk of recurrence in patients with esophageal carcinoma treated with surgery: A single institution analysis consisting of 1002 cases. Oncology Letters, 5, 185-190. https://doi.org/10.3892/ol.2012.1007
MLA
Xu, Y., Chen, Q., Yu, X., Zhou, X., Zheng, X., Mao, W."Factors influencing the risk of recurrence in patients with esophageal carcinoma treated with surgery: A single institution analysis consisting of 1002 cases". Oncology Letters 5.1 (2013): 185-190.
Chicago
Xu, Y., Chen, Q., Yu, X., Zhou, X., Zheng, X., Mao, W."Factors influencing the risk of recurrence in patients with esophageal carcinoma treated with surgery: A single institution analysis consisting of 1002 cases". Oncology Letters 5, no. 1 (2013): 185-190. https://doi.org/10.3892/ol.2012.1007
Copy and paste a formatted citation
x
Spandidos Publications style
Xu Y, Chen Q, Yu X, Zhou X, Zheng X and Mao W: Factors influencing the risk of recurrence in patients with esophageal carcinoma treated with surgery: A single institution analysis consisting of 1002 cases. Oncol Lett 5: 185-190, 2013.
APA
Xu, Y., Chen, Q., Yu, X., Zhou, X., Zheng, X., & Mao, W. (2013). Factors influencing the risk of recurrence in patients with esophageal carcinoma treated with surgery: A single institution analysis consisting of 1002 cases. Oncology Letters, 5, 185-190. https://doi.org/10.3892/ol.2012.1007
MLA
Xu, Y., Chen, Q., Yu, X., Zhou, X., Zheng, X., Mao, W."Factors influencing the risk of recurrence in patients with esophageal carcinoma treated with surgery: A single institution analysis consisting of 1002 cases". Oncology Letters 5.1 (2013): 185-190.
Chicago
Xu, Y., Chen, Q., Yu, X., Zhou, X., Zheng, X., Mao, W."Factors influencing the risk of recurrence in patients with esophageal carcinoma treated with surgery: A single institution analysis consisting of 1002 cases". Oncology Letters 5, no. 1 (2013): 185-190. https://doi.org/10.3892/ol.2012.1007
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