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Article

A tailored health surveillance program unveils a case of MALT lymphoma in an HCV-positive health-care worker

  • Authors:
    • Venerando Rapisarda
    • Andrea Marconi
    • Saverio Candido
    • Daria Nicolosi
    • Mario Salmeri
    • Pietro Gangemi
    • Lidia Proietti
    • Demetrios A. Spandidos
    • Massimo Bracci
    • Cettina Fenga
    • Massimo Libra
  • View Affiliations / Copyright

    Affiliations: Section of Occupational Medicine, Department of Internal Medicine and Systemic Diseases, University of Catania, I-95125 Catania, Italy, Department of Biomedical Sciences, Section of Pathology and Oncology, Laboratory of Translational Oncology and Functional Genomics, University of Catania, I-95124 Catania, Italy, Pathology Unit, Vittorio Emanuele Hospital, I-95100 Catania, Italy, Department of Virology, Medical School, University of Crete, Heraklion 71003, Greece, Department of Clinical and Molecular Sciences, Occupational Medicine Section Polytechnic University of Marche, I-60020 Ancona, Italy, Section of Occupational Medicine, Department of Social and Environmental Medicine, University of Messina, I-98125 Messina, Italy
  • Pages: 651-654
    |
    Published online on: November 15, 2012
       https://doi.org/10.3892/ol.2012.1028
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Abstract

Non-Hodgkin lymphoma (NHL) may occur among hepatitis C virus (HCV)-infected individuals. HCV is one of the most common blood-borne pathogens transmitted from patients to health‑care workers (HCWs). The development of NHL among HCV-infected HCWs has recently been shown. To investigate this issue further a tailored health surveillance program was applied to 3,138 HCWs from four Medical Institutions. To this aim, all employees were screened for both anti-HCV antibodies and HCV-related extrahepatic manifestations. The HCV prevalence rate, similar among all the HCW subgroups, was 7.3%. The occurrence of a gastric mucosa‑associated lymphoma tissue (MALT) lymphoma, diagnosed in a physician following a long history of HCV chronic infection, was observed. Molecular characterization of MALT tissue indicated that immunoglobuline gene combinations were those usually found among HCV-associated lymphomas. Furthermore, B-cell expansion exhibited t(14;18) translocation, as a genetic abnormality associated with the development of MALT lymphomas from HCV-positive patients. Overall, these findings support the hypothesis that HCV viral infection potentially affects the pathway of transformation and progression of lymphoma cells. The occurrence of B-cell NHL, among HCV-positive HCWs, is an additional reason to apply the standard precautions to reduce the risk of blood-borne pathogen transmission.
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Copy and paste a formatted citation
Spandidos Publications style
Rapisarda V, Marconi A, Candido S, Nicolosi D, Salmeri M, Gangemi P, Proietti L, Spandidos DA, Bracci M, Fenga C, Fenga C, et al: A tailored health surveillance program unveils a case of MALT lymphoma in an HCV-positive health-care worker. Oncol Lett 5: 651-654, 2013.
APA
Rapisarda, V., Marconi, A., Candido, S., Nicolosi, D., Salmeri, M., Gangemi, P. ... Libra, M. (2013). A tailored health surveillance program unveils a case of MALT lymphoma in an HCV-positive health-care worker. Oncology Letters, 5, 651-654. https://doi.org/10.3892/ol.2012.1028
MLA
Rapisarda, V., Marconi, A., Candido, S., Nicolosi, D., Salmeri, M., Gangemi, P., Proietti, L., Spandidos, D. A., Bracci, M., Fenga, C., Libra, M."A tailored health surveillance program unveils a case of MALT lymphoma in an HCV-positive health-care worker". Oncology Letters 5.2 (2013): 651-654.
Chicago
Rapisarda, V., Marconi, A., Candido, S., Nicolosi, D., Salmeri, M., Gangemi, P., Proietti, L., Spandidos, D. A., Bracci, M., Fenga, C., Libra, M."A tailored health surveillance program unveils a case of MALT lymphoma in an HCV-positive health-care worker". Oncology Letters 5, no. 2 (2013): 651-654. https://doi.org/10.3892/ol.2012.1028
Copy and paste a formatted citation
x
Spandidos Publications style
Rapisarda V, Marconi A, Candido S, Nicolosi D, Salmeri M, Gangemi P, Proietti L, Spandidos DA, Bracci M, Fenga C, Fenga C, et al: A tailored health surveillance program unveils a case of MALT lymphoma in an HCV-positive health-care worker. Oncol Lett 5: 651-654, 2013.
APA
Rapisarda, V., Marconi, A., Candido, S., Nicolosi, D., Salmeri, M., Gangemi, P. ... Libra, M. (2013). A tailored health surveillance program unveils a case of MALT lymphoma in an HCV-positive health-care worker. Oncology Letters, 5, 651-654. https://doi.org/10.3892/ol.2012.1028
MLA
Rapisarda, V., Marconi, A., Candido, S., Nicolosi, D., Salmeri, M., Gangemi, P., Proietti, L., Spandidos, D. A., Bracci, M., Fenga, C., Libra, M."A tailored health surveillance program unveils a case of MALT lymphoma in an HCV-positive health-care worker". Oncology Letters 5.2 (2013): 651-654.
Chicago
Rapisarda, V., Marconi, A., Candido, S., Nicolosi, D., Salmeri, M., Gangemi, P., Proietti, L., Spandidos, D. A., Bracci, M., Fenga, C., Libra, M."A tailored health surveillance program unveils a case of MALT lymphoma in an HCV-positive health-care worker". Oncology Letters 5, no. 2 (2013): 651-654. https://doi.org/10.3892/ol.2012.1028
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