Giant extragastrointestinal stromal tumor in the transverse mesocolon concomitant with gastric cancer in an elderly patient: Case report

Xue,Dong; Chen,Hongqiang; Chen,Yuxin

doi:10.3892/ol.2012.1030

Giant extragastrointestinal stromal tumor in the transverse mesocolon concomitant with gastric cancer in an elderly patient: Case report

Authors:
- Dong Xue
- Hongqiang Chen
- Yuxin Chen
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Affiliations: Department of General Surgery, Qilu Hospital, Shandong University, Jinan 250012, P.R. China
Published online on: November 16, 2012 https://doi.org/10.3892/ol.2012.1030
Pages: 627-630

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Abstract

Extragastrointestinal stromal tumors (EGISTs) are neoplasms located outside the gastrointestinal tract in sites including the omentum, mesentery and retroperitoneum. EGISTs of the transverse mesocolon are rarely noted in the literature. Herein, we describe a rare case of giant EGIST concomitant with gastric cancer in a 78-year-old male who presented with upper abdominal pain and a palpable mass. The patient underwent en bloc resection of the tumor with a distal gastrectomy, with a D2 lymphadenectomy for the gastric cancer, accompanied with resection of a segment of the transverse colon. The patient received targeted therapy (imatinib 400 mg, daily) and adjuvant chemotherapy with FOLFOX (six cycles). Neither recurrence nor metastasis was observed after 24 months of follow-up.

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1.	Miettinen M, Monihan JM, Sarlomo-Rikala M, Kovatich AJ, Carr NJ, Emory TS and Sobin LH: Gastrointestinal stromal tumors/smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 cases. Am J Surg Pathol. 23:1109–1118. 1999. View Article : Google Scholar
2.	Reith JD, Goldblum JR, Lyles RH and Weiss SW: Extragastrointestinal (soft tissue) stromal tumors: an analysis of 48 cases with emphasis on histologic predictors of outcome. Mod Pathol. 13:577–585. 2000. View Article : Google Scholar : PubMed/NCBI
3.	Zheng S, Huang KE, Tao DY and Pan YL: Gene mutations and prognostic factors analysis in extragastrointestinal stromal tumor of a Chinese three-center study. J Gastrointest Surg. 15:675–681. 2011. View Article : Google Scholar : PubMed/NCBI
4.	Vij M, Agrawal V and Pandey R: Malignant extra-gastrointestinal stromal tumor of the pancreas. A case report and review of literature. JOP. 12:200–204. 2011.PubMed/NCBI
5.	Yeung CK, Yuen CH, Chan IK and Chu RW: Malignant extra-gastrointestinal stromal tumour of diaphragm. ANZ J Surg. 78:923–924. 2008. View Article : Google Scholar : PubMed/NCBI
6.	Barros A, Linhares E, Valadão M, Gonçalves R, Vilhena B, Gil C and Ramos C: Extragastrointestinal stromal tumors (EGIST): a series of case reports. Hepatogastroenterology. 58:865–868. 2011.PubMed/NCBI
7.	Alkhatib L, Albtoush O, Bataineh N, Gharaibeh K, Matalka I and Tokuda Y: Extragastrointestinal Stromal Tumor (EGIST) in the abdominal wall: Case report and literature review. Int J Surg Case Rep. 2:253–255. 2011. View Article : Google Scholar : PubMed/NCBI
8.	Agaimy A, Wünsch PH, Sobin LH, Lasota J and Miettinen M: Occurrence of other malignancies in patients with gastrointestinal stromal tumors. Semin Diagn Pathol. 23:120–129. 2006. View Article : Google Scholar : PubMed/NCBI
9.	Jakobs K, de Gheldere CD and Vanclooster P: A ruptured gastrointestinal stromal tumor of the transverse mesocolon: a case report. Acta Chir Belg. 106:218–221. 2006.PubMed/NCBI
10.	Paparelli C, Cavallaro G, Basso L, Polistena A, Mingazzini PL and De Toma G: Giant GIST of the mesocolon: report of a case. Minerva Chir. 61:537–540. 2006.PubMed/NCBI
11.	Terada T: Primary extragastrointestinal stromal tumor of the transverse mesocolon without c-kit mutations but with PDGFRA mutations. Med Oncol. 26:233–237. 2009. View Article : Google Scholar : PubMed/NCBI
12.	Terada T: Primary multiple extragastrointestinal stromal tumors of the omentum with different mutations of c-kit gene. World J Gastroenterol. 14:7256–7259. 2008. View Article : Google Scholar : PubMed/NCBI
13.	Cruz RJ Jr, Vincenzi R, Ketzer BM, Cecilio AL and Cepeda LA: Spontaneous intratumoral bleeding and rupture of giant gastric stromal tumor (> 30 cm) in a young patient. World J Surg Oncol. 6:762008.PubMed/NCBI
14.	Dedemadi G, Georgoulis G, Kontopanos D, Anagnostou E, Morphopoulos G, Emile JF and Christopoulos C: Extragastrointestinal stromal tumors of the omentum: review apropos of a case with a novel gain-of-function KIT mutation. J Gastrointest Cancer. 40:73–78. 2009. View Article : Google Scholar : PubMed/NCBI
15.	Miettinen M, Makhlouf H, Sobin LH and Lasota J: Gastrointestinal stromal tumors of the jejunum and ileum: a clinicopathologic, imunohistochemical, and molecular genetic study of 906 cases before imatinib with long-term follow-up. Am J Surg Pathol. 30:477–489. 2006. View Article : Google Scholar
16.	Castillo-Sang M, Mancho S, Tsang AW, Gociman B, Almaroof B and Ahmed MY: A malignant omental extra-gastrointestinal stromal tumor on a young man: a case report and review of the literature. World J Surg Oncol. 6:502008. View Article : Google Scholar : PubMed/NCBI
17.	Llenas-García J, Guerra-Vales JM, Moreno A, et al: Primary extragastrointestinal stromal tumors in the omentum and mesentery: a clinicopathological and immunohistochemical study. Hepatogastroenterology. 55:1002–1005. 2008.PubMed/NCBI
18.	Kim KH, Nelson SD, Kim DH, et al: Diagnostic relevance of overexpressions of PKC-θ and DOG-1 and KIT/PDGFRA gene mutations in extragastrointestinal stromal tumors: A Korean six-centers study of 28 cases. Anticancer Res. 32:923–937. 2012.PubMed/NCBI
19.	Casali PG, Jost L, Reichardt P, et al: ESMO Guidelines Working Group: Gastrointestinal stromal tumors: ESMO clinical recommendations for diagnosis, treatment and follow up. Ann Oncol. S2:ii35–38. 2008.PubMed/NCBI
20.	Li J, Gong JF, Li J, Gao J, Sun NP and Shen L: Efficacy of imatinib dose escalation in Chinese gastrointestinal stromal tumor patients. World J Gastroenterol. 18:698–703. 2012. View Article : Google Scholar : PubMed/NCBI