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Article

High expression of FER tyrosine kinase predicts poor prognosis in clear cell renal cell carcinoma

  • Authors:
    • Can Wei
    • Song Wu
    • Xianxin Li
    • Yadong Wang
    • Rui Ren
    • Yongqing Lai
    • Jiongxian Ye
  • View Affiliations / Copyright

    Affiliations: Medical Department, The University of Hong Kong-Shenzhen Hospital, Shenzhen, P.R. China, Department of Urology, Peking University Shenzhen Hospital, Shenzhen, P.R. China, Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen P.R. China, Medical Department, The First Clinical College, Anhui Medical University, Hefei, P.R. China
  • Pages: 473-478
    |
    Published online on: November 16, 2012
       https://doi.org/10.3892/ol.2012.1032
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Abstract

FER tyrosine kinase (FER) has been demonstrated to play a critical role in tumorigenesis and metastasis; however, its potential value as a novel prognostic marker for clear cell renal cell carcinoma (ccRCC) remains unclear. In 48 paired samples of ccRCCs and normal adjacent tissues (ADTs), real‑time PCR was used to evaluate the expression of FER mRNA. The expression of FER protein was assessed in 87 ADTs and 206 samples of ccRCC using immunohistochemical methods. Statistical analysis was used to examine the correlations between the expression levels of FER and the clinical characteristics of ccRCC patients. A significant difference was identified between ccRCC tissues and ADTs in the mRNA levels of FER. Immunohistochemistry analyses revealed higher expression of FER protein in 87 ccRCC samples compared to the paired ADTs. In addition, FER protein expression in 206 ccRCC samples was significantly correlated with tumor size, T stage, N classification, metastasis, recurrence and Fuhrman grade, while associations with age and gender were not identifed. The Kaplan-Meier survival analysis showed that patients with high FER levels had a poorer survival outcome compared with those with lower levels. The log-rank test demonstrated that the cumulative survival rates were significantly different between the two groups. The Cox regression analysis indicated that FER expression, N stage and distant metastasis were independent prognostic factors for overall survival of ccRCC patients. Our results indicate that overexpression of FER in tumor tissues predicts a poor prognosis of patients with ccRCC, and FER may serve as a novel prognostic marker for ccRCC.
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Copy and paste a formatted citation
Spandidos Publications style
Wei C, Wu S, Li X, Wang Y, Ren R, Lai Y and Ye J: High expression of FER tyrosine kinase predicts poor prognosis in clear cell renal cell carcinoma. Oncol Lett 5: 473-478, 2013.
APA
Wei, C., Wu, S., Li, X., Wang, Y., Ren, R., Lai, Y., & Ye, J. (2013). High expression of FER tyrosine kinase predicts poor prognosis in clear cell renal cell carcinoma. Oncology Letters, 5, 473-478. https://doi.org/10.3892/ol.2012.1032
MLA
Wei, C., Wu, S., Li, X., Wang, Y., Ren, R., Lai, Y., Ye, J."High expression of FER tyrosine kinase predicts poor prognosis in clear cell renal cell carcinoma". Oncology Letters 5.2 (2013): 473-478.
Chicago
Wei, C., Wu, S., Li, X., Wang, Y., Ren, R., Lai, Y., Ye, J."High expression of FER tyrosine kinase predicts poor prognosis in clear cell renal cell carcinoma". Oncology Letters 5, no. 2 (2013): 473-478. https://doi.org/10.3892/ol.2012.1032
Copy and paste a formatted citation
x
Spandidos Publications style
Wei C, Wu S, Li X, Wang Y, Ren R, Lai Y and Ye J: High expression of FER tyrosine kinase predicts poor prognosis in clear cell renal cell carcinoma. Oncol Lett 5: 473-478, 2013.
APA
Wei, C., Wu, S., Li, X., Wang, Y., Ren, R., Lai, Y., & Ye, J. (2013). High expression of FER tyrosine kinase predicts poor prognosis in clear cell renal cell carcinoma. Oncology Letters, 5, 473-478. https://doi.org/10.3892/ol.2012.1032
MLA
Wei, C., Wu, S., Li, X., Wang, Y., Ren, R., Lai, Y., Ye, J."High expression of FER tyrosine kinase predicts poor prognosis in clear cell renal cell carcinoma". Oncology Letters 5.2 (2013): 473-478.
Chicago
Wei, C., Wu, S., Li, X., Wang, Y., Ren, R., Lai, Y., Ye, J."High expression of FER tyrosine kinase predicts poor prognosis in clear cell renal cell carcinoma". Oncology Letters 5, no. 2 (2013): 473-478. https://doi.org/10.3892/ol.2012.1032
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