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Article

A new t(9;11;20;22)(q34;p11.2;q11.21;q11) in a Philadelphia-positive chronic myeloid leukemia case

  • Authors:
    • Walid Al-Achkar
    • Abdulsamad Wafa
    • Thomas Liehr
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Biology and Biotechnology, Human Genetics Division, Atomic Energy Commission, Damascus, Syria, Jena University Hospital, Institute of Human Genetics, Jena, Germany
  • Pages: 605-608
    |
    Published online on: November 21, 2012
       https://doi.org/10.3892/ol.2012.1039
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Abstract

The so-called Philadelphia (Ph) chromosome is found in over 90% of cases of chronic myeloid leukemia (CML). Of these cases, 2-10% demonstrate complex translocations involving a third chromosome in addition to chromosomes 9 and 22. Since the majority of CML cases are currently treated with imatinib, variant rearrangements tend to have no specific prognostic significance, although the mechanisms involved in resistance to therapy have yet to be investigated. This study evaluated a CML case with complex chromosomal aberrations not previously observed. A four‑chromosome translocation involving chromosomal regions including 11p11.2 and 20q11.21 in addition to 9q34 and 22q11 was characterized in detail using array-proven multicolor banding (aMCB), a technique which has proven to be of significance in characterizing breakpoint regions in detail. Underlying mechanisms and prognostic factors are discussed.
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Copy and paste a formatted citation
Spandidos Publications style
Al-Achkar W, Wafa A and Liehr T: A new t(9;11;20;22)(q34;p11.2;q11.21;q11) in a Philadelphia-positive chronic myeloid leukemia case. Oncol Lett 5: 605-608, 2013.
APA
Al-Achkar, W., Wafa, A., & Liehr, T. (2013). A new t(9;11;20;22)(q34;p11.2;q11.21;q11) in a Philadelphia-positive chronic myeloid leukemia case. Oncology Letters, 5, 605-608. https://doi.org/10.3892/ol.2012.1039
MLA
Al-Achkar, W., Wafa, A., Liehr, T."A new t(9;11;20;22)(q34;p11.2;q11.21;q11) in a Philadelphia-positive chronic myeloid leukemia case". Oncology Letters 5.2 (2013): 605-608.
Chicago
Al-Achkar, W., Wafa, A., Liehr, T."A new t(9;11;20;22)(q34;p11.2;q11.21;q11) in a Philadelphia-positive chronic myeloid leukemia case". Oncology Letters 5, no. 2 (2013): 605-608. https://doi.org/10.3892/ol.2012.1039
Copy and paste a formatted citation
x
Spandidos Publications style
Al-Achkar W, Wafa A and Liehr T: A new t(9;11;20;22)(q34;p11.2;q11.21;q11) in a Philadelphia-positive chronic myeloid leukemia case. Oncol Lett 5: 605-608, 2013.
APA
Al-Achkar, W., Wafa, A., & Liehr, T. (2013). A new t(9;11;20;22)(q34;p11.2;q11.21;q11) in a Philadelphia-positive chronic myeloid leukemia case. Oncology Letters, 5, 605-608. https://doi.org/10.3892/ol.2012.1039
MLA
Al-Achkar, W., Wafa, A., Liehr, T."A new t(9;11;20;22)(q34;p11.2;q11.21;q11) in a Philadelphia-positive chronic myeloid leukemia case". Oncology Letters 5.2 (2013): 605-608.
Chicago
Al-Achkar, W., Wafa, A., Liehr, T."A new t(9;11;20;22)(q34;p11.2;q11.21;q11) in a Philadelphia-positive chronic myeloid leukemia case". Oncology Letters 5, no. 2 (2013): 605-608. https://doi.org/10.3892/ol.2012.1039
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