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Article

Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells

  • Authors:
    • Zhang Sen
    • Xiao Kai Zhan
    • Jin Jing
    • Zhang Yi
    • Zhou Wanqi
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P.R. China, Department of Hematology and Oncology, Chaoyang Hospital, Capital Medical University, Beijing 100043, P.R. China
  • Pages: 641-644
    |
    Published online on: November 22, 2012
       https://doi.org/10.3892/ol.2012.1042
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Abstract

Cyclotides comprise a family of circular mini-peptides that have been isolated from various plants and have a wide range of bioactivities. Previous studies have demonstrated that cyclotides have antitumor effects and cause cell death by membrane permeabilization. The present study aimed to evaluate the cytotoxicity and chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells. In this study, a total of seven cyclotides were selected for colorimetric cell viability assay (MTT assay) to evaluate their anticancer and chemosensitizing activities in the lung cancer cell line A549 and its sub-line A549/paclitaxel. Results suggested that certain cyclotides had significant anticancer and chemosensitizing abilities; such cyclotides were capable of causing multi-fold decreases in the half maximal inhibitory concentration (IC50) value of cliotides in the presence of paclitaxel. More importantly, their bioactivities were found to be correlated with their net charge status. In conclusion, cyclotides from C. ternatea have potential in chemosensitization application.
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Copy and paste a formatted citation
Spandidos Publications style
Sen Z, Zhan XK, Jing J, Yi Z and Wanqi Z: Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells. Oncol Lett 5: 641-644, 2013.
APA
Sen, Z., Zhan, X.K., Jing, J., Yi, Z., & Wanqi, Z. (2013). Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells. Oncology Letters, 5, 641-644. https://doi.org/10.3892/ol.2012.1042
MLA
Sen, Z., Zhan, X. K., Jing, J., Yi, Z., Wanqi, Z."Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells". Oncology Letters 5.2 (2013): 641-644.
Chicago
Sen, Z., Zhan, X. K., Jing, J., Yi, Z., Wanqi, Z."Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells". Oncology Letters 5, no. 2 (2013): 641-644. https://doi.org/10.3892/ol.2012.1042
Copy and paste a formatted citation
x
Spandidos Publications style
Sen Z, Zhan XK, Jing J, Yi Z and Wanqi Z: Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells. Oncol Lett 5: 641-644, 2013.
APA
Sen, Z., Zhan, X.K., Jing, J., Yi, Z., & Wanqi, Z. (2013). Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells. Oncology Letters, 5, 641-644. https://doi.org/10.3892/ol.2012.1042
MLA
Sen, Z., Zhan, X. K., Jing, J., Yi, Z., Wanqi, Z."Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells". Oncology Letters 5.2 (2013): 641-644.
Chicago
Sen, Z., Zhan, X. K., Jing, J., Yi, Z., Wanqi, Z."Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells". Oncology Letters 5, no. 2 (2013): 641-644. https://doi.org/10.3892/ol.2012.1042
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