Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
February 2013 Volume 5 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February 2013 Volume 5 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Pathological and computed tomography findings of lymphoepithelioma‑like gastric carcinoma with epithelioid granulomas: A case report

  • Authors:
    • Shuguang Liu
    • Long Jin
    • Xiaoyan Xu
    • Ni Lin
    • Bin Lei
    • Hong Shen
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P.R. China, Department of Pathology, Fujian Provincial Hospital, Fuzhou, P.R. China, Department of Pathology, People's Hospital of Zhengzhou Attached to Southern Medical University, Zhengzhou, P.R. China , Huiqiao Department, Nanfang Hospital, Southern Medical University, Guangzhou, P.R. China
  • Pages: 549-551
    |
    Published online on: December 12, 2012
       https://doi.org/10.3892/ol.2012.1070
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Lymphoepithelioma‑like carcinoma is a distinct entity among Epstein‑Barr virus (EBV)‑associated gastric carcinomas, characterized by the presence of a lymphoid stroma with small nests of cancer cells uniformly distributed throughout. Epithelioid granulomas with multinucleated giant cells are extremely rare in the tumor tissue. The presence of epithelioid granulomas with prominent lymphocyte infiltration is associated with a favorable prognosis. This lesion tends to form a bulging mass in the submucosa. In the present study, we report a lymphoepithelioma‑like carcinoma of the stomach with epithelioid granulomas which appeared as a bulging mass in CT scanning and correlate it with the pathology. Clinicians and radiologists should recognize the features of such tumors.
View Figures

Figure 1

Figure 2

Figure 3

View References

1. 

Arikawa J, Tokunaga M, Satoh E, Tanaka S and Land CE: Morphological characteristics of Epstein-Barr virus-related early gastric carcinoma: a case-control study. Pathol Int. 47:360–367. 1997. View Article : Google Scholar : PubMed/NCBI

2. 

Chen JN, He D, Tang F and Shao CK: Epstein-Barr virus-associated gastric carcinoma: a newly defined entity. J Clin Gastroenterol. 46:262–271. 2012. View Article : Google Scholar : PubMed/NCBI

3. 

Murphy G, Pfeiffer R, Camargo MC and Rabkin CS: Meta-analysis shows that prevalence of Epstein-Barr virus-positive gastric cancer differs based on sex and anatomic location. Gastroenterology. 137:824–833. 2009. View Article : Google Scholar : PubMed/NCBI

4. 

Fukayama M and Ushiku T: Epstein-Barr virus-associated gastric carcinoma. Pathol Res Pract. 207:529–537. 2011. View Article : Google Scholar : PubMed/NCBI

5. 

Tamura T, Hamada T, Sako T, et al: Lymphoepithelioma-Like Carcinoma of the Stomach with Epithelioid Granulomas. Case Rep Gastroenterol. 4:361–368. 2010. View Article : Google Scholar : PubMed/NCBI

6. 

Herath CH and Chetty R: Epstein-Barr virus-associated lymphoepithelioma-like gastric carcinoma. Arch Pathol Lab Med. 132:706–709. 2008.PubMed/NCBI

7. 

Lee JH, Kim SH, Han SH, An JS, Lee ES and Kim YS: Clinicopathological and molecular characteristics of Epstein-Barr virus-associated gastric carcinoma: a meta-analysis. J Gastroenterol Hepatol. 24:354–365. 2009. View Article : Google Scholar : PubMed/NCBI

8. 

Torlakovic G, Snover DC and Torlakovic E: Simultaneous EBV-positive lymphoepithelioma-like carcinoma and EBV-negative intestinal-type adenocarcinoma in a patient with Helicobacter pylori-associated chronic gastritis. Am J Clin Pathol. 121:237–243. 2004. View Article : Google Scholar : PubMed/NCBI

9. 

Sousa H, Pinto-Correia AL, Medeiros R and Dinis-Ribeiro M: Epstein-Barr virus is associated with gastric carcinoma: the question is what is the significance? World J Gastroenterol. 14:4347–4351. 2008. View Article : Google Scholar : PubMed/NCBI

10. 

Matsunou H, Konishi F, Hori H, et al: Characteristics of Epstein-Barr virus-associated gastric carcinoma with lymphoid stroma in Japan. Cancer. 77:1998–2004. 1996. View Article : Google Scholar : PubMed/NCBI

11. 

Oda K, Tamaru J, Takenouchi T, et al: Association of Epstein-Barr virus with gastric carcinoma with lymphoid stroma. Am J Pathol. 143:1063–1071. 1993.PubMed/NCBI

12. 

Lü BJ, Lai M, Cheng L, Xu JY and Huang Q: Gastric medullary carcinoma, a distinct entity associated with microsatellite instability-H, prominent intraepithelial lymphocytes and improved prognosis. Histopathology. 45:485–492. 2004.

13. 

Shah KM and Young LS: Epstein-Barr virus and carcinogenesis: beyond Burkitt’s lymphoma. Clin Microbiol Infect. 15:982–988. 2009.

14. 

Song HJ, Srivastava A, Lee J, et al: Host inflammatory response predicts survival of patients with Epstein-Barr virus-associated gastric carcinoma. Gastroenterology. 139:84–92. 2010. View Article : Google Scholar : PubMed/NCBI

15. 

Wu MS, Shun CT, Wu CC, et al: Epstein-Barr virus-associated gastric carcinomas: relation to H. pylori infection and genetic alterations. Gastroenterology. 118:1031–1038. 2000. View Article : Google Scholar : PubMed/NCBI

16. 

Nishikawa J, Yanai H, Mizugaki Y, Takada K, Tada M and Okita K: Case report: hypoechoic submucosal nodules: a sign of Epstein-Barr virus-associated early gastric cancer. J Gastroenterol Hepatol. 13:585–590. 1998. View Article : Google Scholar : PubMed/NCBI

17. 

Maeda E, Akahane M, Uozaki H, et al: CT appearance of Epstein-Barr virus-associated gastric carcinoma. Abdom Imaging. 34:618–625. 2009. View Article : Google Scholar : PubMed/NCBI

18. 

Yanai H, Nishikawa J, Mizugaki Y, et al: Endoscopic and pathologic features of Epstein-Barr virus-associated gastric carcinoma. Gastrointest Endosc. 45:236–242. 1997. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu S, Jin L, Xu X, Lin N, Lei B and Shen H: Pathological and computed tomography findings of lymphoepithelioma‑like gastric carcinoma with epithelioid granulomas: A case report. Oncol Lett 5: 549-551, 2013.
APA
Liu, S., Jin, L., Xu, X., Lin, N., Lei, B., & Shen, H. (2013). Pathological and computed tomography findings of lymphoepithelioma‑like gastric carcinoma with epithelioid granulomas: A case report. Oncology Letters, 5, 549-551. https://doi.org/10.3892/ol.2012.1070
MLA
Liu, S., Jin, L., Xu, X., Lin, N., Lei, B., Shen, H."Pathological and computed tomography findings of lymphoepithelioma‑like gastric carcinoma with epithelioid granulomas: A case report". Oncology Letters 5.2 (2013): 549-551.
Chicago
Liu, S., Jin, L., Xu, X., Lin, N., Lei, B., Shen, H."Pathological and computed tomography findings of lymphoepithelioma‑like gastric carcinoma with epithelioid granulomas: A case report". Oncology Letters 5, no. 2 (2013): 549-551. https://doi.org/10.3892/ol.2012.1070
Copy and paste a formatted citation
x
Spandidos Publications style
Liu S, Jin L, Xu X, Lin N, Lei B and Shen H: Pathological and computed tomography findings of lymphoepithelioma‑like gastric carcinoma with epithelioid granulomas: A case report. Oncol Lett 5: 549-551, 2013.
APA
Liu, S., Jin, L., Xu, X., Lin, N., Lei, B., & Shen, H. (2013). Pathological and computed tomography findings of lymphoepithelioma‑like gastric carcinoma with epithelioid granulomas: A case report. Oncology Letters, 5, 549-551. https://doi.org/10.3892/ol.2012.1070
MLA
Liu, S., Jin, L., Xu, X., Lin, N., Lei, B., Shen, H."Pathological and computed tomography findings of lymphoepithelioma‑like gastric carcinoma with epithelioid granulomas: A case report". Oncology Letters 5.2 (2013): 549-551.
Chicago
Liu, S., Jin, L., Xu, X., Lin, N., Lei, B., Shen, H."Pathological and computed tomography findings of lymphoepithelioma‑like gastric carcinoma with epithelioid granulomas: A case report". Oncology Letters 5, no. 2 (2013): 549-551. https://doi.org/10.3892/ol.2012.1070
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team