Expression of steroid and xenobiotic receptor in uterine carcinosarcoma, leiomyosarcoma and endometrial stromal sarcoma

Yue,Xiaoni; Utsunomiya,Hiroki; Akahira,Jun-Ichi; Suzuki,Fumihiko; Ito,Kiyoshi; Nagase,Satoru; Sasano,Hironobu; Yaegashi,Nobuo

doi:10.3892/ol.2012.1094

March 2013 Volume 5 Issue 3

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March 2013 Volume 5 Issue 3

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Article

Expression of steroid and xenobiotic receptor in uterine carcinosarcoma, leiomyosarcoma and endometrial stromal sarcoma

Authors:
- Xiaoni Yue
- Hiroki Utsunomiya
- Jun-Ichi Akahira
- Fumihiko Suzuki
- Kiyoshi Ito
- Satoru Nagase
- Hironobu Sasano
- Nobuo Yaegashi
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, Graduate School of Medicine, Tohoku University, Sendai 980-8574, Japan, Department of Pathology, Graduate School of Medicine, Tohoku University, Sendai 980-8574, Japan
Pages: 835-839
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Published online on: December 28, 2012

https://doi.org/10.3892/ol.2012.1094
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Abstract

We analyzed the expression of the steroid and xenobiotic receptor (SXR) in human uterine sarcomas and evaluated its clinical significance. Forty-seven cases with archival specimens were examined for SXR expression using immunohistochemistry. All cases were scored using a semi-quantitative histological scoring (HSCORE) method. Specimens with a HSCORE >40 were regarded as SXR-positive. Various clinicopathological variables, including the expression status of estrogen receptor (ER)-α, progesterone receptor (PR) and Ki67 (MIB-1) were examined. The mean SXR HSCOREs of carcinosarcoma (CS) and leiomyosarcoma (LMS) were 9.13 and 23.6, respectively, and SXR-positive rates were 3 out of 24 (12.5%) and 4 out of 17 (23.5%), respectively. SXR was not detected in endometrial stromal sarcoma (ESS). In CS cases, significant differences were detected between the expression of SXR and age and disease stages. There was no significant correlation between SXR-positive status and either disease-free survival or overall survival. Our results support an association between SXR and malignant behavior. Our results show that overexpression of SXR may represent a useful marker to identify patients with advanced-stage CS. In addition, our results showed that SXR may aid in the diagnosis of uterine sarcomas.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Expression of steroid and xenobiotic receptor in uterine carcinosarcoma, leiomyosarcoma and endometrial stromal sarcoma

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Abstract

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