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November 2012 Volume 4 Issue 5

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Downregulation of KLF4 and the Bcl-2/Bax ratio in advanced epithelial ovarian cancer

  • Authors:
    • Ok Yoon
    • Jaesook Roh
  • View Affiliations / Copyright

    Affiliations: Department of Anatomy and Cell Biology, College of Medicine, Hanyang University, Seoul 133-791, Republic of Korea
  • Pages: 1033-1036
    |
    Published online on: July 30, 2012
       https://doi.org/10.3892/ol.2012.834
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Abstract

Kruppel-like factor 4 (KLF4) is a key transcriptional regulator of cell differentiation and proliferation and an altered expression of KLF4 has been reported in a number of human malignancies. In the present study, we investigated KLF4 expression and its role in cell proliferation in advanced epithelial ovarian cancer (EOC). We compared KLF4, Bcl-2 and Bax transcript levels in ovaries isolated from advanced EOC and normal control ovaries. In addition, the KLF4 gene was transduced into ovarian cancer cells and transcript levels of Bcl-2 and Bax and cell proliferation were analyzed by real‑time RT-PCR and MTT assays, respectively. Ovarian KLF4 expression and Bcl-2/Bax ratios were downregulated in most cases of advanced EOC. In addition, KLF4 overexpression in ovarian cancer cells increased the Bcl-2/Bax ratio. However, MTT analysis indicated that the overexpression of KLF4 had no effect on the proliferation of ovarian cancer cells. The inactivation of KLF4 is frequently observed in ovarian cancers and a reduced expression of KLF4 in the ovarian cancers may lead to a reduction in the Bcl-2/Bax ratio. The latter has a role in predicting cancer grade, although its exact role in ovarian carcinogenesis requires clarification.
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Copy and paste a formatted citation
Spandidos Publications style
Yoon O and Roh J: Downregulation of KLF4 and the Bcl-2/Bax ratio in advanced epithelial ovarian cancer. Oncol Lett 4: 1033-1036, 2012.
APA
Yoon, O., & Roh, J. (2012). Downregulation of KLF4 and the Bcl-2/Bax ratio in advanced epithelial ovarian cancer. Oncology Letters, 4, 1033-1036. https://doi.org/10.3892/ol.2012.834
MLA
Yoon, O., Roh, J."Downregulation of KLF4 and the Bcl-2/Bax ratio in advanced epithelial ovarian cancer". Oncology Letters 4.5 (2012): 1033-1036.
Chicago
Yoon, O., Roh, J."Downregulation of KLF4 and the Bcl-2/Bax ratio in advanced epithelial ovarian cancer". Oncology Letters 4, no. 5 (2012): 1033-1036. https://doi.org/10.3892/ol.2012.834
Copy and paste a formatted citation
x
Spandidos Publications style
Yoon O and Roh J: Downregulation of KLF4 and the Bcl-2/Bax ratio in advanced epithelial ovarian cancer. Oncol Lett 4: 1033-1036, 2012.
APA
Yoon, O., & Roh, J. (2012). Downregulation of KLF4 and the Bcl-2/Bax ratio in advanced epithelial ovarian cancer. Oncology Letters, 4, 1033-1036. https://doi.org/10.3892/ol.2012.834
MLA
Yoon, O., Roh, J."Downregulation of KLF4 and the Bcl-2/Bax ratio in advanced epithelial ovarian cancer". Oncology Letters 4.5 (2012): 1033-1036.
Chicago
Yoon, O., Roh, J."Downregulation of KLF4 and the Bcl-2/Bax ratio in advanced epithelial ovarian cancer". Oncology Letters 4, no. 5 (2012): 1033-1036. https://doi.org/10.3892/ol.2012.834
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