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November 2012 Volume 4 Issue 5

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Article

Antitumor activity of Endostar combined with radiation against human nasopharyngeal carcinoma in mouse xenograft models

  • Authors:
    • Juying Zhou
    • Lili Wang
    • Xiaoting Xu
    • Yu Tu
    • Songbing Qin
    • Yuzhen Yin
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, The First Affiliated Hospital of Suzhou University, Suzhou, Jiangsu, P.R. China, School of Radiation Medicine and Public Health, Medical College of Soochow University, Suzhou, Jiangsu, P.R. China
  • Pages: 976-980
    |
    Published online on: August 8, 2012
       https://doi.org/10.3892/ol.2012.856
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Abstract

Radiation treatment for nasopharyngeal carcinoma (NPC) is common and effective. However, local recurrence occurs frequently. Endostar, a novel recombinant human endostatin, is an antiangiogenic drug with a potent antitumor effect. The present study aimed to observe and explore the radiosensitization effects of Endostar on NPC and its underlying mechanism. The NPC subcutaneous transplantation tumor animal model was established to evaluate the antitumor activity of Endostar combined with radiation (Endostar + radiation) treatment compared with monotherapy (Endostar or radiation). Tumor growth and tumor weight were measured to evaluate the antitumor effect. The level of vascular endothelial growth factor (VEGF) and microvessel density (MVD) were measured using immunohistochemical staining of the tumor tissues. Significant antitumor activity was found in the Endostar + radiation group. The tumor inhibition rates of Endostar, radiation and Endostar + radiation were 27.12, 60.45 and 86.11%, respectively. The VEGF levels in the tumor tissue in the Endostar + radiation group were lower than those in the radiation and control groups. The MVD in the tumor tissues in the Endostar + radiation group was 12.2±2.5, lower than that in the Endostar (29.3±3.4), radiation (23.5±3.6) and control (44.7±5.1) groups. These results suggest that Endostar increases the radiation sensitivity of NPC-transplanted tumors in nude mice by lowering VEGF expression. In this study, the NPC animal model was established, which reflects the efficacy of clinical combination therapies and the combination of Endostar and radiation. The mechanisms of the combination therapies should be further investigated using this model.
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1. 

WB YinXZ GuNasopharyngeal carcinomaRadiation Oncology4th editionPeking Union Medical College PressBeijing4802007

2. 

D KwongJ ShamD ChoyThe effect of loco-regional control on distant metastastic dissemination in nasopharyngeal carcinoma: an analysis of 1301 patientsInt J Radiat Oncol Biol Phys3010291036199410.1016/0360-3016(94)90306-97961008

3. 

AB Langeland MarthinsenA Dybdahl WanderasS LundgrenT StrickertEffects of growth factors on growth and radiation sensitivity of the human breast cancer cell line T-47DOncol Rep9397403200211836616

4. 

KE HovingaLJ StalpersC Van BreeRadiation-enhanced vascular endothelial growth factor (VEGF) secretion in glioblastoma multiforme cell lines - a clue to radioresistanceJ Neurooncol7499103200510.1007/s11060-004-4204-716193379

5. 

J FolkmanRole of angiogenesis in tumor growth and metastasisSemin Oncol291518200210.1053/sonc.2002.3726312516034

6. 

AL FeldmanNP RestifoHR AlexanderAntiangiogenic gene therapy of cancer utilizing a recombinant adenovirus to elevate systemic endostatin levels in miceCancer Res6015031506200010749112

7. 

Y LingY YangN LuEndostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cellsBiochem Biophys Res Commun3617984200710.1016/j.bbrc.2007.06.155

8. 

T MäkitieP SummanenA TarkkanenMicrovascular density in predicting survival of patients with choroidal and ciliary body melanomaInvest Ophthalmol Vis Sci4024712480199910509639

9. 

M TokurakuH SatoS MurakamiActivation of the precursor of gelatinase A/72 kDa type IV collagenase/MMP-2 in lung carcinomas correlates with the expression of membrane-type matrix metalloproteinase (MT-MMP) and with lymph node metastasisInt J Cancer64355359199510.1002/ijc.29106405137591310

10. 

A GergerA El-KhoueiryW ZhangPharmacogenetic angiogenesis profiling for first-line Bevacizumab plus oxaliplatin-based chemotherapy in patients with metastatic colorectal cancerClin Cancer Res1757835792201110.1158/1078-0432.CCR-11-111521791631

11. 

J MaCS ChenT BluteDJ WaxmanAntiangiogenesis enhances intratumoral drug retentionCancer Res7126752685201110.1158/0008-5472.CAN-10-324221447737

12. 

ZX WangSM WangQ ZhouEndostatin in different administration routes combined with adriamycin chemotherapy in the treatment of liver cancer xenograft in miceNan Fang Yi Ke Da Xue Xue Bao30190319052010(In Chinese)

13. 

BA TeicherN DupuisT KusomotoAntiangiogenic agents can increase tumor oxygenation and response to radiation therapyRad Oncol Invest2269276199410.1002/roi.2970020604

14. 

N Hansen-AlgenstaedtBR StollTP PaderaTumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapyCancer Res60455645602000

15. 

X LuoJM SlaterDS GridleyRadiation and endostatin gene therapy in a lung carcinoma model: pilot data on cells and cytokines that affect angiogenesis and immune statusTechol Cancer Res Treat5135146200610.1177/15330346060050020716551133

16. 

S ItasakaR KomakiRS HerbstEndostatin improves radioresponse and blocks tumor revascularization after radiation therapy for A431 xenograft in miceInt J Radiat Oncol Biol Phys67870878200710.1016/j.ijrobp.2006.10.03017293237

17. 

CG LeeM HeijnE di TomasoAnti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditionCancer Res6055655570200011034104

18. 

A AbdollahiKE LipsonX HanSU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct antiendothelial action of radiation in vitroCancer Res63375537632003

19. 

A KaliskiL LassauL MaggiorellaAntiangiogenic effect and tumor growth control achieved by an MMP-inhibitor combined to radiation in vivo, targeting radio-induced MMP-2 enhancement and VEGF modulationInt J Radiat Oncol Biol Phys60368369200410.1016/j.ijrobp.2004.07.218

20. 

Z TopolovecA CorusićD BabićVascular endothelial growth factor and intratumoral microvessel density as prognostic factors in endometrial cancerColl Antropol34447453201020698116

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Copy and paste a formatted citation
Spandidos Publications style
Zhou J, Wang L, Xu X, Tu Y, Qin S and Yin Y: Antitumor activity of Endostar combined with radiation against human nasopharyngeal carcinoma in mouse xenograft models. Oncol Lett 4: 976-980, 2012.
APA
Zhou, J., Wang, L., Xu, X., Tu, Y., Qin, S., & Yin, Y. (2012). Antitumor activity of Endostar combined with radiation against human nasopharyngeal carcinoma in mouse xenograft models. Oncology Letters, 4, 976-980. https://doi.org/10.3892/ol.2012.856
MLA
Zhou, J., Wang, L., Xu, X., Tu, Y., Qin, S., Yin, Y."Antitumor activity of Endostar combined with radiation against human nasopharyngeal carcinoma in mouse xenograft models". Oncology Letters 4.5 (2012): 976-980.
Chicago
Zhou, J., Wang, L., Xu, X., Tu, Y., Qin, S., Yin, Y."Antitumor activity of Endostar combined with radiation against human nasopharyngeal carcinoma in mouse xenograft models". Oncology Letters 4, no. 5 (2012): 976-980. https://doi.org/10.3892/ol.2012.856
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou J, Wang L, Xu X, Tu Y, Qin S and Yin Y: Antitumor activity of Endostar combined with radiation against human nasopharyngeal carcinoma in mouse xenograft models. Oncol Lett 4: 976-980, 2012.
APA
Zhou, J., Wang, L., Xu, X., Tu, Y., Qin, S., & Yin, Y. (2012). Antitumor activity of Endostar combined with radiation against human nasopharyngeal carcinoma in mouse xenograft models. Oncology Letters, 4, 976-980. https://doi.org/10.3892/ol.2012.856
MLA
Zhou, J., Wang, L., Xu, X., Tu, Y., Qin, S., Yin, Y."Antitumor activity of Endostar combined with radiation against human nasopharyngeal carcinoma in mouse xenograft models". Oncology Letters 4.5 (2012): 976-980.
Chicago
Zhou, J., Wang, L., Xu, X., Tu, Y., Qin, S., Yin, Y."Antitumor activity of Endostar combined with radiation against human nasopharyngeal carcinoma in mouse xenograft models". Oncology Letters 4, no. 5 (2012): 976-980. https://doi.org/10.3892/ol.2012.856
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