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November 2012 Volume 4 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Lymph node micrometastases detected by carcinoembryonic antigen mRNA affect long-term survival and disease‑free interval in early-stage lung cancer patients

  • Authors:
    • Mario Nosotti
    • Alessandro Palleschi
    • Lorenzo Rosso
    • Davide Tosi
    • Luigi Santambrogio
    • Paolo Mendogni
    • Antonella Marzorati
    • Ilaria Righi
    • Silvano Bosari
  • View Affiliations / Copyright

    Affiliations: Thoracic Surgery and Lung Transplantation Unit, Foundation IRCCS (Scientific Institute for Research Hospitalization and Health Care), Ca' Granda General Hospital, University of Milan, Milan, Italy, Division of Pathology, Foundation IRCCS (Scientific Institute for Research Hospitalization and Health Care), Ca' Granda General Hospital, University of Milan, Milan, Italy
  • Pages: 1140-1144
    |
    Published online on: August 24, 2012
       https://doi.org/10.3892/ol.2012.880
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Abstract

The majority of stage I lung cancer patients undergo a complete resection of their tumor; however, they still harbor a considerable risk of mortality due to recurrences. A correlation between the presence of lymph node micrometastases and poor prognosis has been observed. The aim of this study was to correlate the lymph node molecular staging with the 5-year survival and disease-free interval following pulmonary lobectomy for non-small cell lung cancer (NSCLC). A quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) for carcinoembryonic antigen (CEA) mRNA was performed on primary lung tumors and regional lymph nodes from 55 surgically resected NSCLC patients classified as clinical stage I. CEA mRNA was found to be present in all the primary tumors. RT-PCR revealed the presence of cancer cells in the lymph nodes of 20 patients (36.3%) and routine staining detected lymph node metastases in 11 patients. Significant differences in survival and disease-free intervals were observed in patients with lymph node micrometastases versus patients with negative lymph nodes (P=0.0026 and P=0.0044, respectively). Multivariate analyses confirmed that micrometastases were an independent predictor for worse prognosis (P=0.0098) and a short disease-free interval (P=0.0137). This study demonstrated strong correlations between the molecular detection of lymph node micrometastases and 5-year survival rates and disease-free interval in patients who underwent pulmonary lobectomy for early-stage lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Nosotti M, Palleschi A, Rosso L, Tosi D, Santambrogio L, Mendogni P, Marzorati A, Righi I and Bosari S: Lymph node micrometastases detected by carcinoembryonic antigen mRNA affect long-term survival and disease‑free interval in early-stage lung cancer patients. Oncol Lett 4: 1140-1144, 2012.
APA
Nosotti, M., Palleschi, A., Rosso, L., Tosi, D., Santambrogio, L., Mendogni, P. ... Bosari, S. (2012). Lymph node micrometastases detected by carcinoembryonic antigen mRNA affect long-term survival and disease‑free interval in early-stage lung cancer patients. Oncology Letters, 4, 1140-1144. https://doi.org/10.3892/ol.2012.880
MLA
Nosotti, M., Palleschi, A., Rosso, L., Tosi, D., Santambrogio, L., Mendogni, P., Marzorati, A., Righi, I., Bosari, S."Lymph node micrometastases detected by carcinoembryonic antigen mRNA affect long-term survival and disease‑free interval in early-stage lung cancer patients". Oncology Letters 4.5 (2012): 1140-1144.
Chicago
Nosotti, M., Palleschi, A., Rosso, L., Tosi, D., Santambrogio, L., Mendogni, P., Marzorati, A., Righi, I., Bosari, S."Lymph node micrometastases detected by carcinoembryonic antigen mRNA affect long-term survival and disease‑free interval in early-stage lung cancer patients". Oncology Letters 4, no. 5 (2012): 1140-1144. https://doi.org/10.3892/ol.2012.880
Copy and paste a formatted citation
x
Spandidos Publications style
Nosotti M, Palleschi A, Rosso L, Tosi D, Santambrogio L, Mendogni P, Marzorati A, Righi I and Bosari S: Lymph node micrometastases detected by carcinoembryonic antigen mRNA affect long-term survival and disease‑free interval in early-stage lung cancer patients. Oncol Lett 4: 1140-1144, 2012.
APA
Nosotti, M., Palleschi, A., Rosso, L., Tosi, D., Santambrogio, L., Mendogni, P. ... Bosari, S. (2012). Lymph node micrometastases detected by carcinoembryonic antigen mRNA affect long-term survival and disease‑free interval in early-stage lung cancer patients. Oncology Letters, 4, 1140-1144. https://doi.org/10.3892/ol.2012.880
MLA
Nosotti, M., Palleschi, A., Rosso, L., Tosi, D., Santambrogio, L., Mendogni, P., Marzorati, A., Righi, I., Bosari, S."Lymph node micrometastases detected by carcinoembryonic antigen mRNA affect long-term survival and disease‑free interval in early-stage lung cancer patients". Oncology Letters 4.5 (2012): 1140-1144.
Chicago
Nosotti, M., Palleschi, A., Rosso, L., Tosi, D., Santambrogio, L., Mendogni, P., Marzorati, A., Righi, I., Bosari, S."Lymph node micrometastases detected by carcinoembryonic antigen mRNA affect long-term survival and disease‑free interval in early-stage lung cancer patients". Oncology Letters 4, no. 5 (2012): 1140-1144. https://doi.org/10.3892/ol.2012.880
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