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Article

Meta‑analysis of the expression of the mitosis‑related gene Fam83D

  • Authors:
    • Lokman Varisli
  • View Affiliations / Copyright

    Affiliations: Department of Biology, Faculty of Science, Harran University, Osmanbey Campus, Sanliurfa, Turkey
  • Pages: 1335-1340
    |
    Published online on: September 20, 2012
       https://doi.org/10.3892/ol.2012.925
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Abstract

The family with sequence similarity 83, member D (Fam83D) encodes a mitotic spindle‑associated protein. Its knockdown results in shorter spindles that fail to organize a correct metaphase plate. In this study, we demonstrated that Fam83D is coexpressed with well‑known mitotic genes. Pathway analysis results also showed that cell cycle‑ and mitosis‑related pathways are enriched with Fam83D-coexpressed genes. Furthermore, Fam83D is differentially expressed in various types of cancers. The results presented in this study suggest that Fam83D may be an important molecule for mitotic progression and equal segregation of chromosomes. Since the molecules that are involved in these mechanisms are crucial for mitosis as well as carcinogenesis, Fam83D should be considered as a novel regulator of mitosis and a putative carcinogenesis‑related gene.
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Copy and paste a formatted citation
Spandidos Publications style
Varisli L: Meta‑analysis of the expression of the mitosis‑related gene Fam83D. Oncol Lett 4: 1335-1340, 2012.
APA
Varisli, L. (2012). Meta‑analysis of the expression of the mitosis‑related gene Fam83D. Oncology Letters, 4, 1335-1340. https://doi.org/10.3892/ol.2012.925
MLA
Varisli, L."Meta‑analysis of the expression of the mitosis‑related gene Fam83D". Oncology Letters 4.6 (2012): 1335-1340.
Chicago
Varisli, L."Meta‑analysis of the expression of the mitosis‑related gene Fam83D". Oncology Letters 4, no. 6 (2012): 1335-1340. https://doi.org/10.3892/ol.2012.925
Copy and paste a formatted citation
x
Spandidos Publications style
Varisli L: Meta‑analysis of the expression of the mitosis‑related gene Fam83D. Oncol Lett 4: 1335-1340, 2012.
APA
Varisli, L. (2012). Meta‑analysis of the expression of the mitosis‑related gene Fam83D. Oncology Letters, 4, 1335-1340. https://doi.org/10.3892/ol.2012.925
MLA
Varisli, L."Meta‑analysis of the expression of the mitosis‑related gene Fam83D". Oncology Letters 4.6 (2012): 1335-1340.
Chicago
Varisli, L."Meta‑analysis of the expression of the mitosis‑related gene Fam83D". Oncology Letters 4, no. 6 (2012): 1335-1340. https://doi.org/10.3892/ol.2012.925
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