Concomitant intraductal papillary mucinous neoplasm and neuroendocrine tumor of the pancreas

Ishida,Mitsuaki; Shiomi,Hisanori; Naka,Shigeyuki; Tani,Tohru; Okabe,Hidetoshi

doi:10.3892/ol.2012.952

January 2013 Volume 5 Issue 1

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

January 2013 Volume 5 Issue 1

Full Size Image

Article

Concomitant intraductal papillary mucinous neoplasm and neuroendocrine tumor of the pancreas

Authors:
- Mitsuaki Ishida
- Hisanori Shiomi
- Shigeyuki Naka
- Tohru Tani
- Hidetoshi Okabe
View Affiliations / Copyright

Affiliations: Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Otsu, Shiga, Japan, Department of Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan
Pages: 63-67
|
Published online on: October 3, 2012

https://doi.org/10.3892/ol.2012.952
Expand metrics +

Abstract

Intraductal papillary mucinous neoplasm (IPMN) and neuroendocrine tumor (NET) of the pancreas are rare tumors and their association is not expected to be frequent. However, certain studies have suggested that the concomitant occurence of these tumors may be more frequent than previously thought. In the current study, we describe a case of concomitant occurrence of IPMN and NET of the pancreas and review the clinicopathological features of previously published cases and the current one. A 68-year-old female was incidentally found to have dilatation of the main pancreatic duct. A distal pancreatectomy was performed under the clinical diagnosis of IPMN. Histopathological analysis revealed concomitant IPMN (low-grade) and NET G1 of the pancreas. Review of the clinicopathological features of the 15 previously reported cases of concomitant IPMN and NET of the pancreas as well as the present one indicated that: i) this condition mainly affects middle-aged females; ii) the main symptom is abdominal or back pain, or no symptoms; iii) a hormone production symptom was observed in only one case; iv) the most common degree of dysplasia of IPMN is low grade; and v) the size of the NET is not particularly large (average 15.1 mm), although the clinical behavior is not always indolent (metastasis was observed in 3 cases). It is well known that IPMNs are associated with a high incidence of extrapancreatic malignancies, including colorectal and gastric carcinomas. Concomitant pancreatic NET and extrapancreatic malignancies may occur, therefore, systemic surveillance of extrapancreatic neoplasms and detection of concomitant NETs of the pancreas are necessary for patients with IPMN.

View Figures

View References

1	Adsay NV, Fukushima N, Furukawa T, et al: Intraductal neoplasms of the pancreas. World Health Organization Classification of Tumours of the Digestive System. Bosman FT, Carneiro F, Hruban RH and Theise ND: IARC; Lyon: pp. 304–313. 2010
2	Klimstra DS, Arnold R, Capella C, et al: Neuroendocrine neoplasms of the pancreas. World Health Organization Classification of Tumours of the Digestive System. Bosman FT, Carneiro F, Hruban RH and Theise ND: IARC; Lyon: pp. 322–326. 2010
3	Marrache F, Cazals-Hatem D, Kianmanesh R, et al: Endocrine tumor and intraductal papillary neoplasm of the pancreas: a fortuitous association? Pancreas. 31:79–83. 2005. View Article : Google Scholar : PubMed/NCBI
4	Volante M, Brizzi MP, Faggiano A, et al: Somatostatin receptor type 2A immunohistochemistry in neuroendocrine tumors: a proposal of scoring system correlated with somatostatin receptor scintigraphy. Mod Pathol. 20:1172–1182. 2007. View Article : Google Scholar : PubMed/NCBI
5	Goh BK, Ooi LL, Kumarasinghe MP, et al: Clinicopathological features of patients with concomitant intraductal papillary mucinous neoplasm of the pancreas and pancreatic endocrine neoplasm. Pancreatology. 6:520–526. 2006. View Article : Google Scholar
6	Zhao X, Stabile BE, Mo J, Wang J and French SW: Nesidioblastosis coexisting with islet cell tumor and intraductal papillary mucinous hyperplasia. Arch Pathol Lab Med. 125:1344–1347. 2001.
7	Stukavec J, Jirasek T, Mandys V, et al: Poorly differentiated endocrine carcinoma and intraductal papillary-mucinous neoplasm of the pancreas: Description of an unusual case. Pathol Res Pract. 203:879–884. 2007. View Article : Google Scholar
8	Larghi A, Stobinski M, Galasso D, Lecca PG and Costamagna G: Concomitant intraductal papillary mucinous neoplasm and pancreatic endocrine tumor: Report of two cases and review of the literature. Dig Liver Dis. 41:759–761. 2009. View Article : Google Scholar
9	Gill KR, Scimeca D, Stauffer J, et al: Pancreatic neuroendocrine tumors among patients with intraductal papillary mucinous neoplasms: real association or just a coincidence? JOP. 10:515–517. 2009.
10	Lamberts SW, Krenning EP and Reubi JC: The role of somatostatin and its analogs in the diagnosis and treatment of tumors. Endocr Rev. 12:450–482. 1991. View Article : Google Scholar : PubMed/NCBI
11	Reisine T and Bell GI: Molecular biology of somatostatin receptors. Endocr Rev. 16:427–442. 1995.PubMed/NCBI
12	Rinke A, Müller H, Schade-Brittinger C, et al: Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: A report from the PROMID Study Group. J Clin Oncol. 27:4656–4663. 2009. View Article : Google Scholar
13	Ishida M, Kushima R, Chano T and Okabe H: Immunohistochemical demonstration of the type III intermediate filament peripherin in human rectal mucosae and well-differentiated endocrine neoplasms. Oncol Rep. 18:633–637. 2007.
14	Ishida M, Kushima R, Brevet M, Chatelain D and Okabe H: Co-expression of neuronal intermediate filaments, peripherin and α-internexin in human well-differentiated endocrine neoplasms (carcinoid tumors) of the appendix. Mol Med Rep. 1:191–195. 2008.
15	Sugiyama M and Atomi Y: Extrapancreatic neoplasms occur with unusual frequency in patients with intraductal papillary mucinous tumors of the pancreas. Am J Gastroenterol. 94:470–473. 1999. View Article : Google Scholar : PubMed/NCBI
16	Sugiyama M, Suzuki Y, Abe N, Mori T and Atomi Y: Management of intraductal papillary mucinous neoplasm of the pancreas. J Gastroenterol. 43:181–185. 2008. View Article : Google Scholar : PubMed/NCBI
17	Ishida M, Egawa S, Kawaguchi K, et al: Synchronous and metachronous extrapancreatic malignant neoplasms in patients with intraductal papillary-mucinous neoplasm of the pancreas. Pancreatology. 8:577–582. 2008. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Concomitant intraductal papillary mucinous neoplasm and neuroendocrine tumor of the pancreas

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Related Articles