Breast metastasis from a pulmonary adenocarcinoma: Case report and review of the literature Retraction in /10.3892/ol.2019.10965

Sanguinetti,Alessandro; Puma,Francesco; Lucchini,Roberta; Santoprete,Stefano; Cirocchi,Roberto; Corsi,Alessia; Triola,Roberta; Avenia,Nicola

doi:10.3892/ol.2012.995

Breast metastasis from a pulmonary adenocarcinoma: Case report and review of the literature

Retraction in: /10.3892/ol.2019.10965

Authors:
- Alessandro Sanguinetti
- Francesco Puma
- Roberta Lucchini
- Stefano Santoprete
- Roberto Cirocchi
- Alessia Corsi
- Roberta Triola
- Nicola Avenia
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Affiliations: Endocrine Surgical Unit, University of Perugia, Umbria, Terni 06100, Italy, Thoracic Surgery Unit, University of Perugia, Umbria, Terni 06100, Italy, General Surgery Unit, University of Perugia, Umbria, Terni 06100, Italy
Published online on: October 25, 2012 https://doi.org/10.3892/ol.2012.995
Pages: 328-332

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Abstract

Breast metastasis from extra-mammary malignancy is rare. An incidence of 0.4-1.3% has been reported in the literature. The primary malignancies most commonly metastasizing to the breast are leukemia, lymphoma and malignant melanoma. We present a case of metastasis to the breast from a pulmonary adenocarcinoma, diagnosed concomitantly with the primary tumor. A 43-year-old female presented with dyspnea and a dry cough of 3 weeks' duration. A subsequent chest radiograph revealed a massive pleural effusion. Additionally, on physical examination, a poorly defined mass was noted in the upper outer quadrant of the right breast. The patient underwent bronchoscopy, simple right mastectomy and medical thoracoscopy. Following cytology, histology and immunohistochemistry, primary lung adenocarcinoma with metastasis to the breast and parietal pleura was diagnosed. Histologically, both the primary and metastatic anatomic sites demonstrated a micropapillary component, which has recently been recognized as an important prognostic factor. Although the patient received chemotherapy, she succumbed to her condition within 8 months. Accurate differentiation of metastasis from primary carcinoma is very important as the treatment and prognosis of the two differ significantly.

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1	National Cancer Institute: Probability of breast cancer in American women. http://www.cancer.gov/cancertopics/factsheet/detection/probability-breastcancer. Accessed March 9, 2012.
2	Hajdu SI and Urban JA: Cancers metastatic to the breast. Cancer. 29:1691–1696. 1972. View Article : Google Scholar : PubMed/NCBI
3	Vizcaino I, Torregrosa A, Higueras V, et al: Metastasis to the breast from extramammary malignancies: a report of four cases and a review of literature. Eur Radiol. 11:1659–1665. 2001. View Article : Google Scholar : PubMed/NCBI
4	Georgiannos SN, Chin J, Goode AW and Sheaff M: Secondary neoplasms of the breast: a survey of the 20th Century. Cancer. 92:2259–2266. 2001. View Article : Google Scholar : PubMed/NCBI
5	Klingen TA, Klaasen H, Aas H, Chen Y and Akslen LA: Secondary breast cancer: a 5-year population-based study with review of the literature. APMIS. 117:762–767. 2009.PubMed/NCBI
6	Sitzenfrey A: Mammakarzinom zwei jahre nach abdominaler radikal operation wegen doppelseitigen carcinoma ovarii. Prag Med Wochenschr. 221–235. 1907.(In German).
7	Williams SA, Ehlers RA II, Hunt KK, et al: Metastases to the breast from nonbreast solid neoplasms: presentation and determinants of survival. Cancer. 110:731–737. 2007. View Article : Google Scholar : PubMed/NCBI
8	Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: GLOBOCAN 2008 v12, Cancer Incidence and Mortality Worldwide: IARC CancerBase No 10 [Internet]. Lyon, France: International Agency for Research on Cancer; 2010, http://globocan.iarc.fr. Accessed March 9, 2012.
9	Masmoudi A, Mathieu MC and Soria JC: Breast metastasis from lung adenocarcinoma: a case report. Anticancer Res. 23:1825–1826. 2003.PubMed/NCBI
10	Ramar K, Pervez H, Potti A and Mehdi S: Breast metastasis from non-small-cell lung carcinoma. Med Oncol. 20:181–184. 2003. View Article : Google Scholar : PubMed/NCBI
11	Gomez-Caro A, Pinero A, Roca MJ, et al: Surgical treatment of solitary metastasis in the male breast from non-small cell lung cancer. Breast J. 12:366–367. 2006. View Article : Google Scholar : PubMed/NCBI
12	Lee AH: The histological diagnosis of metastases to the breast from extramammary malignancies. J Clin Pathol. 60:1333–1341. 2007. View Article : Google Scholar : PubMed/NCBI
13	Nassar H: Carcinomas with micropapillary morphology: clinical significance and current concepts. Adv Anat Pathol. 11:297–303. 2004. View Article : Google Scholar : PubMed/NCBI
14	Amin MB, Tamboli P, Merchant SH, et al: Micropapillary component in lung adenocarcinoma: a distinctive histologic feature with possible prognostic significance. Am J Surg Pathol. 26:358–364. 2002. View Article : Google Scholar : PubMed/NCBI
15	Maeda R, Isowa N, Onuma H, et al: Lung adenocarcinomas with micropapillary components. Gen Thorac Cardiovasc Surg. 57:534–539. 2009. View Article : Google Scholar : PubMed/NCBI
16	Matthews MJ: Problems in morphology and behaviour of bronchopulmonary malignant disease. Lung Cancer: Natural History, Prognosis and Therapy. Isreal L and Chahanian P: Academic Press; New York: pp. 23–62. 1976
17	Toombs BD and Kalisher L: Metastatic disease to the breast: clinical, pathologic, and radiographic features. AJR Am J Roentgenol. 129:673–676. 1977. View Article : Google Scholar : PubMed/NCBI
18	Noguera JJ, Martinez-Miravete P, Idoate F, et al: Metastases to the breast: a review of 33 cases. Australas Radiol. 51:133–138. 2007. View Article : Google Scholar : PubMed/NCBI
19	Verger E, Conill C, Velasco M and Sole M: Metastasis in the male breast from a lung adenocarcinoma. Acta Oncol. 31:4791992. View Article : Google Scholar : PubMed/NCBI
20	Sadikot RT, Renwick DS, DaCosta P, Chalmers AG and Pearson SB: Breast metastasis from non-small cell lung cancer. South Med J. 90:1063–1064. 1997. View Article : Google Scholar : PubMed/NCBI
21	Lee SH, Park JM, Kook SH, Han BK and Moon WK: Metastatic tumors to the breast: mammographic and ultrasonographic findings. J Ultrasound Med. 19:257–262. 2000.PubMed/NCBI
22	Yeh CN, Lin CH and Chen MF: Clinical and ultrasonographic characteristics of breast metastases from extramammary malignancies. Am Surg. 70:287–290. 2004.PubMed/NCBI
23	Komorowski AL, Wysocki WM and Mitus J: Metastasis to the breast - a clinical challenge in outpatient. Acta Chir Belg. 105:59–61. 2005.PubMed/NCBI
24	Ucar N, Kurt OK, Alpar S, Orsel O, Demirag F and Kurt B: Breast metastasis in a male patient with nonsmall cell lung carcinoma. South Med J. 100:850–851. 2007. View Article : Google Scholar : PubMed/NCBI
25	Fulciniti F, Losito S, Botti G, et al: Metastases to the breast: role of fine needle cytology samples. Our experience with nine cases in 2 years. Ann Oncol. 19:682–687. 2008.PubMed/NCBI
26	Hsu W, Sheen-Chen SM, Wang JL, Huang CC and Ko SF: Squamous cell lung carcinoma metastatic to the breast. Anticancer Res. 28:1299–1301. 2008.PubMed/NCBI
27	Wood B, Sterrett G, Frost F and Swarbrick N: Diagnosis of extra-mammary malignancy metastatic to the breast by fine needle biopsy. Pathology. 40:345–351. 2008. View Article : Google Scholar : PubMed/NCBI
28	Nielsen M, Andersen JA, Henriksen FW, et al: Metastases to the breast from extramammary carcinomas. Acta Pathol Microbiol Scand A. 89:251–256. 1981.PubMed/NCBI
29	Muttarak M, Nimmonrat A and Chaiwun B: Metastatic carcinoma to the male and female breast. Australas Radiol. 42:16–19. 1998. View Article : Google Scholar
30	Lee SK, Kim WW, Kim SH, et al: Characteristics of metastasis in the breast from extramammary malignancies. J Surg Oncol. 101:137–140. 2010. View Article : Google Scholar : PubMed/NCBI
31	Kuroda N, Hamaguchi N, Takeuchi E, Ohara M, Hirouchi T and Mizuno K: Lung adenocarcinoma with a micropapillary pattern: a clinicopathological study of 25 cases. APMIS. 114:381–385. 2006. View Article : Google Scholar : PubMed/NCBI
32	Klingen TA, Chen Y, Gundersen MD, Aas H, Westre B and Sauer T: Thyroid transcription factor-1 positive primary breast cancer: a case report with review of the literature. Diagn Pathol. 5:372010. View Article : Google Scholar : PubMed/NCBI
33	Yang M and Nonaka D: A study of immunohistochemical differential expression in pulmonary and mammary carcinomas. Mod Pathol. 23:654–661. 2010. View Article : Google Scholar : PubMed/NCBI
34	Zamecnik J and Kodet R: Value of thyroid transcription factor-1 and surfactant apoprotein A in the differential diagnosis of pulmonary carcinomas: a study of 109 cases. Virchows Arch. 440:353–361. 2002. View Article : Google Scholar
35	Takeda Y, Tsuta K, Shibuki Y, et al: Analysis of expression patterns of breast cancer-specific markers (mammaglobin and gross cystic disease fluid protein 15) in lung and pleural tumors. Arch Pathol Lab Med. 132:239–243. 2008.PubMed/NCBI
36	Gomez-Fernandez C, Mejias A, Walker G and Nadji M: Immunohistochemical expression of estrogen receptor in adenocarcinomas of the lung: the antibody factor. Appl Immunohistochem Mol Morphol. 18:137–141. 2010. View Article : Google Scholar : PubMed/NCBI
37	Striebel JM, Dacic S and Yousem SA: Gross cystic disease fluid protein-(GCDFP-15): expression in primary lung adenocarcinoma. Am J Surg Pathol. 32:426–432. 2008. View Article : Google Scholar : PubMed/NCBI
38	Bhargava R, Beriwal S and Dabbs DJ: Mammaglobin vs GCDFP-15: an immunohistologic validation survey for sensitivity and specificity. Am J Clin Pathol. 127:103–113. 2007. View Article : Google Scholar : PubMed/NCBI