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Article

Small cell carcinoma of the prostate after high-dose-rate brachytherapy for low-risk prostatic adenocarcinoma

  • Authors:
    • Akira Komiya
    • Kenji Yasuda
    • Tetsuo Nozaki
    • Yasuyoshi  Fujiuchi
    • Shin-Ichi Hayashi
    • Hideki Fuse
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama 930-0194, Japan, Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama 930-0194, Japan
  • Pages: 53-56
    |
    Published online on: October 25, 2012
       https://doi.org/10.3892/ol.2012.998
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Abstract

In the present study, we describe an 80-year-old patient who developed prostatic small cell carcinoma (SCC) following high‑dose-rate brachytherapy (HDR-BT) for low‑risk prostatic adenocarcinoma. The patient received one implant of Ir-192 and 7 fractions of 6.5 Gy within 3.5 days, for a total prescribed dose of 45.5 Gy. A total of 27 months after HDR-BT, the patient complained of difficulty in urinating. His serum prostate-specific antigen (PSA) levels were 3.2 ng/ml. Systemic examination revealed an enlargement of the prostate, urethral stenosis, pelvic lymph node swelling and multiple lung and bone lesions. His serum neuron-specific enolase (NSE) levels were elevated to 120 ng/ml. A prostate needle biopsy was performed for pathological examination. Histologically, there were tumor cells with hyperchromatic nuclei and scant cytoplasm showing a solid or trabecular growth pattern. Immunohistochemically, they were positive for AE1/AE3, CD56 and synaptophysin, and negative for PSA, PAP and CD57. These findings are consistent with SCC of the prostate. A review of the prostate needle biopsy specimen prior to HDR-BT did not reveal any tumor cells positive for chromogranin A, nor synaptophysin. The final diagnosis was SCC of the prostate with local progression, with lung, lymph node and bone metastases. Three cycles of etoposide/cisplatin (EP) were administered. A greater than 50% decrease in the serum NSE levels was observed. However, there was no objective response. Due to the deterioration of the patient's general condition, EP was discontinued. One month later, his serum NSE showed a rapid increase to 210 ng/ml with aggressive local progression and the patient succumbed to the disease 5.5 months after the start of EP therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Komiya A, Yasuda K, Nozaki T, Fujiuchi Y, Hayashi S and Fuse H: Small cell carcinoma of the prostate after high-dose-rate brachytherapy for low-risk prostatic adenocarcinoma. Oncol Lett 5: 53-56, 2013.
APA
Komiya, A., Yasuda, K., Nozaki, T., Fujiuchi, Y., Hayashi, S., & Fuse, H. (2013). Small cell carcinoma of the prostate after high-dose-rate brachytherapy for low-risk prostatic adenocarcinoma. Oncology Letters, 5, 53-56. https://doi.org/10.3892/ol.2012.998
MLA
Komiya, A., Yasuda, K., Nozaki, T., Fujiuchi, Y., Hayashi, S., Fuse, H."Small cell carcinoma of the prostate after high-dose-rate brachytherapy for low-risk prostatic adenocarcinoma". Oncology Letters 5.1 (2013): 53-56.
Chicago
Komiya, A., Yasuda, K., Nozaki, T., Fujiuchi, Y., Hayashi, S., Fuse, H."Small cell carcinoma of the prostate after high-dose-rate brachytherapy for low-risk prostatic adenocarcinoma". Oncology Letters 5, no. 1 (2013): 53-56. https://doi.org/10.3892/ol.2012.998
Copy and paste a formatted citation
x
Spandidos Publications style
Komiya A, Yasuda K, Nozaki T, Fujiuchi Y, Hayashi S and Fuse H: Small cell carcinoma of the prostate after high-dose-rate brachytherapy for low-risk prostatic adenocarcinoma. Oncol Lett 5: 53-56, 2013.
APA
Komiya, A., Yasuda, K., Nozaki, T., Fujiuchi, Y., Hayashi, S., & Fuse, H. (2013). Small cell carcinoma of the prostate after high-dose-rate brachytherapy for low-risk prostatic adenocarcinoma. Oncology Letters, 5, 53-56. https://doi.org/10.3892/ol.2012.998
MLA
Komiya, A., Yasuda, K., Nozaki, T., Fujiuchi, Y., Hayashi, S., Fuse, H."Small cell carcinoma of the prostate after high-dose-rate brachytherapy for low-risk prostatic adenocarcinoma". Oncology Letters 5.1 (2013): 53-56.
Chicago
Komiya, A., Yasuda, K., Nozaki, T., Fujiuchi, Y., Hayashi, S., Fuse, H."Small cell carcinoma of the prostate after high-dose-rate brachytherapy for low-risk prostatic adenocarcinoma". Oncology Letters 5, no. 1 (2013): 53-56. https://doi.org/10.3892/ol.2012.998
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