Glioma in the third trimester of pregnancy: Two cases and a review of the literature

Wu,Jie; Ma,Yan-Hui; Wang,Tian-Long

doi:10.3892/ol.2013.1106

Glioma in the third trimester of pregnancy: Two cases and a review of the literature

Authors:
- Jie Wu
- Yan-Hui Ma
- Tian-Long Wang
View Affiliations

Affiliations: Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China
Published online on: January 4, 2013 https://doi.org/10.3892/ol.2013.1106
Pages: 943-946

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

We present two cases of glioma (WHO grade III) in pregnant females presenting in the third trimester. Gliomas during pregnancy are rare. At present, the association between gliomas and pregnancy is poorly understood and little has been reported with regard to the management of patients with gliomas in pregnancy. Management of these cases presents a medical dilemma. Gliomas during pregnancy pose a risk to maternal and fetal life. The benefit‑to‑risk ratio should be carefully evaluated and discussed prior to surgery. In the present cases, caesarean section (CS) followed by craniotomy was performed under the same general anesthesia at 34 weeks' gestation. The mothers received radiotherapy and chemotherapy following surgery. They have been followed up to the present date and remain in good health. These two cases indicate that early CS followed by craniotomy is an effective choice in pregnant patients with gliomas at ≥34 weeks' gestation. In the present study, we describe these two cases and review the literature with regard to gliomas during pregnancy.

View Figures

View References

1	Cantwell R, Clutton-Brock T, Cooper G, et al: Saving Mothers’ Lives: Reviewing maternal deaths to make motherhood safer: 2006–2008. The Eighth Report of Confidential Enquiries into Maternal Deaths in the United Kingdom. BJOG. 118(Suppl 1): 1–203. 2011.
2	Terry AR, Barker FG 2nd, Leffert L, Bateman BT, Souter I and Plotkin SR: Outcomes of hospitalization in pregnant women with CNS neoplasms: a population-based study. Neuro Oncol. 14:768–776. 2012. View Article : Google Scholar : PubMed/NCBI
3	Chang L, Looi-Lyons L, Bartosik L and Tindal S: Anesthesia for cesarean section in two patients with brain tumours. Can J Anaesth. 46:61–65. 1999. View Article : Google Scholar : PubMed/NCBI
4	Haas JF, Jänisch W and Staneczek W: Newly diagnosed primary intracranial neoplasms in pregnant women: a population-based assessment. J Neurol Neurosurg Psychiatry. 49:874–880. 1986. View Article : Google Scholar : PubMed/NCBI
5	Pallud J, Duffau H, Razak RA, et al: Influence of pregnancy in the behavior of diffuse gliomas: clinical cases of a French glioma study group. J Neurol. 256:2014–2020. 2009. View Article : Google Scholar : PubMed/NCBI
6	Ducray F, Colin P, Cartalat-Carel S, et al: Management of malignant gliomas diagnosed during pregnancy. Rev Neurol (Paris). 162:322–329. 2006.(In French).
7	Lynch JC, Gouvêa F, Emmerich JC, Kokinovrachos G, Pereira C, Welling L and Kislanov S: Management strategy for brain tumour diagnosed during pregnancy. Br J Neurosurg. 25:225–230. 2011. View Article : Google Scholar : PubMed/NCBI
8	Cutura N and Soldo V: Preterm delivery in a patient with frontal lobe brain tumor. Vojnosanit Pregl. 66:830–832. 2009.(In Serbian).
9	Chaudhuri P and Wallenburg HC: Brain tumors and pregnancy. Presentation of a case and a review of the literature. Eur J Obstet Gynecol Reprod Biol. 11:109–114. 1980. View Article : Google Scholar : PubMed/NCBI
10	Nossek E, Ekstein M, Rimon E, Kupferminc MJ and Ram Z: Neurosurgery and pregnancy. Acta Neurochir (Wien). 153:1727–1735. 2011. View Article : Google Scholar
11	Ng J and Kitchen N: Neurosurgery and pregnancy. J Neurol Neurosurg Psychiatry. 79:745–752. 2008. View Article : Google Scholar
12	Goldschlager T, Steyn M, Loh V, Selvanathan S, Vonau M and Campbell S: Simultaneous craniotomy and caesarean section for trauma. J Trauma. 66:E50–E51. 2009. View Article : Google Scholar : PubMed/NCBI
13	Morris JA Jr, Rosenbower TJ, Jurkovich GJ, et al: Infant survival after cesarean section for trauma. Ann Surg. 223:481–491. 1996. View Article : Google Scholar : PubMed/NCBI
14	Kal HB and Struikmans H: Radiotherapy during pregnancy: fact and fiction. Lancet Oncol. 6:328–333. 2005. View Article : Google Scholar : PubMed/NCBI
15	Wang LP and Paech MJ: Neuroanesthesia for the pregnant woman. Anesth Analg. 107:193–200. 2008. View Article : Google Scholar
16	Stupp R, Mason WP, van den Bent MJ, et al: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 352:987–996. 2005. View Article : Google Scholar : PubMed/NCBI
17	Tewari KS, Cappuccini F, Asrat T, Flamm BL, Carpenter SE, Disaia PJ and Quilligan EJ: Obstetric emergencies precipitated by malignant brain tumors. Am J Obstet Gynecol. 182:1215–1221. 2000. View Article : Google Scholar : PubMed/NCBI