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Article

Prevalence of hepatitis B and C in patients with meningiomas and glioblastoma multiforme

  • Authors:
    • Marc B. Cabanne
    • Quang D. Ma
    • Lillian Mecum
    • Rahul Jandial
    • Javed Siddiqi
    • Mike Y. Chen
  • View Affiliations / Copyright

    Affiliations: Division of Neurosurgery, Arrowhead Regional Medical Center, Colton, CA 92324, USA, Division of Neurosurgery, City of Hope National Medical Center, MOB 2001J, Duarte, CA 91010, USA
  • Pages: 783-786
    |
    Published online on: January 10, 2013
       https://doi.org/10.3892/ol.2013.1126
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Abstract

The prevalence of hepatitis B and C in patients with glioblastoma multiforme or meningiomas has not been described. These infections are known to modulate the activity of the immune system, which potentially influences the development and course of cancer. We hypothesized that chronic hepatitis infection, which activates the immune system, decreases the risk of brain tumors, particularly those that are highly malignant. We performed a retrospective study to examine the prevalence of hepatitis B and C in patients with meningiomas and glioblastomas. The combined prevalence of hepatitis B and C in the USA from 1999‑2008 was 5.7%. The prevalence of hepatitis B and C in patients with meningiomas was 2.4%; while among glioblastoma patients, the prevalence of hepatitis B and C was 1.38%. The odds ratio of having hepatitis B or C with glioblastoma versus meningiomas was 0.56, with a confidence interval of 0.19-1.6 and a P-value of 0.29. Compared with historical controls, the prevalence of hepatitis B and C in meningioma and glioblastoma patients was decreased. However, this difference may be attributed to the retrospective nature of our data and the natural history of hepatitis B and C infections. The prevalence of these viral infections was not statistically different in patients with meningiomas and glioblastomas. This suggests that hepatitis B and C primarily influence slow-growing, benign tumors and more aggressive cancers equally, if at all. To definitively test our hypothesis, future studies in which data are prospectively gathered are likely to be required.
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Copy and paste a formatted citation
Spandidos Publications style
Cabanne MB, Ma QD, Mecum L, Jandial R, Siddiqi J and Chen MY: Prevalence of hepatitis B and C in patients with meningiomas and glioblastoma multiforme. Oncol Lett 5: 783-786, 2013.
APA
Cabanne, M.B., Ma, Q.D., Mecum, L., Jandial, R., Siddiqi, J., & Chen, M.Y. (2013). Prevalence of hepatitis B and C in patients with meningiomas and glioblastoma multiforme. Oncology Letters, 5, 783-786. https://doi.org/10.3892/ol.2013.1126
MLA
Cabanne, M. B., Ma, Q. D., Mecum, L., Jandial, R., Siddiqi, J., Chen, M. Y."Prevalence of hepatitis B and C in patients with meningiomas and glioblastoma multiforme". Oncology Letters 5.3 (2013): 783-786.
Chicago
Cabanne, M. B., Ma, Q. D., Mecum, L., Jandial, R., Siddiqi, J., Chen, M. Y."Prevalence of hepatitis B and C in patients with meningiomas and glioblastoma multiforme". Oncology Letters 5, no. 3 (2013): 783-786. https://doi.org/10.3892/ol.2013.1126
Copy and paste a formatted citation
x
Spandidos Publications style
Cabanne MB, Ma QD, Mecum L, Jandial R, Siddiqi J and Chen MY: Prevalence of hepatitis B and C in patients with meningiomas and glioblastoma multiforme. Oncol Lett 5: 783-786, 2013.
APA
Cabanne, M.B., Ma, Q.D., Mecum, L., Jandial, R., Siddiqi, J., & Chen, M.Y. (2013). Prevalence of hepatitis B and C in patients with meningiomas and glioblastoma multiforme. Oncology Letters, 5, 783-786. https://doi.org/10.3892/ol.2013.1126
MLA
Cabanne, M. B., Ma, Q. D., Mecum, L., Jandial, R., Siddiqi, J., Chen, M. Y."Prevalence of hepatitis B and C in patients with meningiomas and glioblastoma multiforme". Oncology Letters 5.3 (2013): 783-786.
Chicago
Cabanne, M. B., Ma, Q. D., Mecum, L., Jandial, R., Siddiqi, J., Chen, M. Y."Prevalence of hepatitis B and C in patients with meningiomas and glioblastoma multiforme". Oncology Letters 5, no. 3 (2013): 783-786. https://doi.org/10.3892/ol.2013.1126
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