Rapid long-lasting biochemical and radiological response to sorafenib in a case of advanced hepatocellular carcinoma

  • Authors:
    • Assunta Maria Teresa Gerardi
    • Luca Pio Stoppino
    • Arcangelo Liso
    • Luca Macarini
    • Matteo Landriscina
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  • Published online on: January 11, 2013     https://doi.org/10.3892/ol.2013.1131
  • Pages: 975-977
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Abstract

The multikinase inhibitor sorafenib has demonstrated an overall survival benefit in phase III hepatocellular carcinoma (HCC) trials and has become the new standard of care for advanced stages of this disease. However, in clinical practice, the vast majority of patients obtain disease stabilization and occasionally tumor shrinkage. Furthermore, the appropriate timing of sorafenib therapy initiation, in order to maximize its clinical activity, remains under debate. We report a case of 4‑year sorafenib treatment in a patient with an advanced hepatitis C virus (HCV)‑related HCC with extensive infiltration of the inferior vena cava. Sorafenib treatment induced a rapid complete biochemical response and a long-term favorable outcome. Additionally, no major toxicities or detrimental effects on quality of life were observed. Thus, it is likely that a subgroup of human HCC may be highly sensitive to sorafenib; new molecular determinants are required to select those patients who may benefit from this therapy. Furthermore, a prompt initiation of treatment when the hepatic function is not compromised is a prerequisite for maximizing the clinical activity of sorafenib.
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February 2013
Volume 5 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Gerardi, A.M., Stoppino, L.P., Liso, A., Macarini, L., & Landriscina, M. (2013). Rapid long-lasting biochemical and radiological response to sorafenib in a case of advanced hepatocellular carcinoma. Oncology Letters, 5, 975-977. https://doi.org/10.3892/ol.2013.1131
MLA
Gerardi, A. M., Stoppino, L. P., Liso, A., Macarini, L., Landriscina, M."Rapid long-lasting biochemical and radiological response to sorafenib in a case of advanced hepatocellular carcinoma". Oncology Letters 5.3 (2013): 975-977.
Chicago
Gerardi, A. M., Stoppino, L. P., Liso, A., Macarini, L., Landriscina, M."Rapid long-lasting biochemical and radiological response to sorafenib in a case of advanced hepatocellular carcinoma". Oncology Letters 5, no. 3 (2013): 975-977. https://doi.org/10.3892/ol.2013.1131