Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April 2013 Volume 5 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April 2013 Volume 5 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Androgen receptor decreases the cytotoxic effects of chemotherapeutic drugs in upper urinary tract urothelial carcinoma cells

  • Authors:
    • Teng-Fu Hsieh
    • Chi-Cheng Chen
    • Ai-Lin Yu
    • Wen-Lung Ma
    • Caixia Zhang
    • Chih-Rong Shyr
    • Chawnshang Chang
  • View Affiliations / Copyright

    Affiliations: Division of Urology, Department of Surgery, Buddhist Tzu Chi General Hospital, Taichung Branch, Taichung 40427, Taiwan, R.O.C., Sex Hormone Research Center, China Medical University/Hospital, Taichung 40454, Taiwan, R.O.C., George Whipple Lab for Cancer Research, Departments of Pathology, Urology and Radiation Oncology and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
  • Pages: 1325-1330
    |
    Published online on: January 18, 2013
       https://doi.org/10.3892/ol.2013.1140
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Upper urinary tract urothelial carcinomas (UUTUCs) represent relatively uncommon yet devastating tumors that affect more males than females. However, the correlation between gender difference and disease progression remains unclear. Androgen and the androgen receptor (AR) were previously hypothesized to account for the gender difference in the incidence of urothelial carcinomas; however, the role of AR in the development and progression of UUTUCs is not well understood. In addition, although UUTUCs are responsive to chemotherapy, various responses are presented among patients. Therefore, the aim of the present study was to determine the role of AR in the response of UUTUC cells to chemotherapeutic drugs. In this study, AR overexpression in UUTUC cells (BFTC 909) was identified to reduce the cytotoxic effect of chemotherapeutic drugs, including doxorubicin, cisplatin and mitomycin C and protected cells from drug‑induced death. The expression of ABCG2, an ATP‑binding cassette half‑transporter associated with multidrug resistance, was increased in AR‑overexpressing BFTC cells. In addition, use of the AR degradation enhancer, ASC‑J9®, repressed the AR effect on increasing cell viability under drug treatment. In summary, results of the present study indicate that the status of AR expression levels in UUTUCs may be a significant factor in affecting the efficacy of chemotherapy and classic chemotherapeutic drugs and AR targeted therapy may provide a novel potential therapeutic approach to improve treatment of UUTUCs.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Kirkali Z and Tuzel E: Transitional cell carcinoma of the ureter and renal pelvis. Crit Rev Oncol Hematol. 47:155–169. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Oosterlinck W, Solsona E, van der Meijden AP, et al: EAU guidelines on diagnosis and treatment of upper urinary tract transitional cell carcinoma. Eur Urol. 46:147–154. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Krogh J, Kvist E and Rye B: Transitional cell carcinoma of the upper urinary tract: prognostic variables and post-operative recurrences. Br J Urol. 67:32–36. 1991. View Article : Google Scholar : PubMed/NCBI

4 

Lehmann J, Suttmann H, Kovac I, et al: Transitional cell carcinoma of the ureter: prognostic factors influencing progression and survival. Eur Urol. 51:1281–1288. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Sanderson KM, Cai J, Miranda G, Skinner DG and Stein JP: Upper tract urothelial recurrence following radical cystectomy for transitional cell carcinoma of the bladder: an analysis of 1,069 patients with 10-year followup. J Urol. 177:2088–2094. 2007.PubMed/NCBI

6 

Hall MC, Womack S, Sagalowsky AI, Carmody T, Erickstad MD and Roehrborn CG: Prognostic factors, recurrence and survival in transitional cell carcinoma of the upper urinary tract: a 30-year experience in 252 patients. Urology. 52:594–601. 1998.PubMed/NCBI

7 

Kang CH, Yu TJ, Hsieh HH, et al: The development of bladder tumors and contralateral upper urinary tract tumors after primary transitional cell carcinoma of the upper urinary tract. Cancer. 98:1620–1626. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Zigeuner RE, Hutterer G, Chromecki T, Rehak P and Langner C: Bladder tumour development after urothelial carcinoma of the upper urinary tract is related to primary tumour location. BJU Int. 98:1181–1186. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Catto JW, Yates DR, Rehman I, et al: Behavior of urothelial carcinoma with respect to anatomical location. J Urol. 177:1715–1720. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Catto JW, Azzouzi AR, Amira N, et al: Distinct patterns of microsatellite instability are seen in tumours of the urinary tract. Oncogene. 22:8699–8706. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Munoz JJ and Ellison LM: Upper tract urothelial neoplasms: incidence and survival during the last 2 decades. J Urol. 164:1523–1525. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Zigeuner R and Pummer K: Urothelial carcinoma of the upper urinary tract: surgical approach and prognostic factors. Eur Urol. 53:720–731. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Turkeri LN: Neo/adjuvant therapy in upper tract urothelial carcinoma. Eur Urol Suppl. 6:549–554. 2007. View Article : Google Scholar

14 

Seaman EK, Slawin KM and Benson MC: Treatment options for upper tract transitional-cell carcinoma. Urol Clin North Am. 20:349–354. 1993.PubMed/NCBI

15 

Miyamoto H, Yang Z, Chen YT, et al: Promotion of bladder cancer development and progression by androgen receptor signals. J Natl Cancer Inst. 99:558–568. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Noronha RF and Rao BR: Sex hormone receptors in localized and advanced transitional cell carcinoma of urinary tract in humans. Urology. 28:401–403. 1986. View Article : Google Scholar : PubMed/NCBI

17 

Boorjian S, Ugras S, Mongan NP, et al: Androgen receptor expression is inversely correlated with pathologic tumor stage in bladder cancer. Urology. 64:383–388. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Tuygun C, Kankaya D, Imamoglu A, et al: Sex-specific hormone receptors in urothelial carcinomas of the human urinary bladder: a comparative analysis of clinicopathological features and survival outcomes according to receptor expression. Urol Oncol. 29:43–51. 2011. View Article : Google Scholar

19 

Imada S, Akaza H, Ami Y, Koiso K, Ideyama Y and Takenaka T: Promoting effects and mechanisms of action of androgen in bladder carcinogenesis in male rats. Eur Urol. 31:360–364. 1997.PubMed/NCBI

20 

Wu JT, Han BM, Yu SQ, Wang HP and Xia SJ: Androgen receptor is a potential therapeutic target for bladder cancer. Urology. 75:820–827. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Shyr CR, Chen CC, Hsieh TF, et al: The expression and actions of androgen receptor in upper urinary tract urothelial carcinoma (UUTUC) tissues and the primary cultured cells. Endocrine. 43:191–199. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Tzeng CC, Liu HS, Li C, et al: Characterization of two urothelium cancer cell lines derived from a blackfoot disease endemic area in Taiwan. Anticancer Res. 16:1797–1804. 1996.PubMed/NCBI

23 

Soga N, Arima K and Sugimura Y: Adjuvant methotrexate, vinblastine, adriamycin and cisplatin chemotherapy has potential to prevent recurrence of bladder tumors after surgical removal of upper urinary tract transitional cell carcinoma. Int J Urol. 15:800–803. 2008. View Article : Google Scholar

24 

Kwak C, Lee SE, Jeong IG and Ku JH: Adjuvant systemic chemotherapy in the treatment of patients with invasive transitional cell carcinoma of the upper urinary tract. Urology. 68:53–57. 2006. View Article : Google Scholar : PubMed/NCBI

25 

O’Donoghue JP and Crew JP: Adjuvant topical treatment of upper urinary tract urothelial tumours. BJU Int. 94:483–485. 2004.PubMed/NCBI

26 

Robey R, Polgar O, Deeken J, To K and Bates S: ABCG2: determining its relevance in clinical drug resistance. Cancer Metastasis Rev. 26:39–57. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Lai JJ, Lai KP, Chuang KH, et al: Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-alpha expression. J Clin Invest. 119:3739–3751. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Ma WL, Hsu CL, Wu MH, et al: Androgen receptor is a new potential therapeutic target for the treatment of hepatocellular carcinoma. Gastroenterology. 135:947–955. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Wu MH, Ma WL, Hsu CL, et al: Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription. Sci Transl Med. 2:32–35. 2010.PubMed/NCBI

30 

Yang Z, Chang YJ, Yu IC, et al: ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor. Nat Med. 13:348–353. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Mir C, Shariat SF, van der Kwast TH, et al: Loss of androgen receptor expression is not associated with pathological stage, grade, gender or outcome in bladder cancer: a large multi-institutional study. BJU Int. 108:24–30. 2011. View Article : Google Scholar : PubMed/NCBI

32 

See WA: Continuous antegrade infusion of adriamycin as adjuvant therapy for upper tract urothelial malignancies. Urology. 56:216–222. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Eastham JA and Huffman JL: Technique of mitomycin C instillation in the treatment of upper urinary tract urothelial tumors. J Urol. 150:324–325. 1993.PubMed/NCBI

34 

Sakamoto N, Naito S, Kumazawa J, et al: Prophylactic intravesical instillation of mitomycin C and cytosine arabinoside for prevention of recurrent bladder tumors following surgery for upper urinary tract tumors: A prospective randomized study. Int J Urol. 8:212–216. 2001. View Article : Google Scholar

35 

Hoffmeyer S, Burk O, von Richter O, et al: Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA. 97:3473–3478. 2000. View Article : Google Scholar

36 

Longley DB and Johnston PG: Molecular mechanisms of drug resistance. J Pathol. 205:275–292. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Szakacs G, Paterson JK, Ludwig JA, Booth-Genthe C and Gottesman MM: Targeting multidrug resistance in cancer. Nat Rev Drug Discov. 5:219–234. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Heinlein CA and Chang C: Androgen receptor in prostate cancer. Endocr Rev. 25:276–308. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Kang HY, Cho CL, Huang KL, et al: Nongenomic androgen activation of phosphatidylinositol 3-kinase/Akt signaling pathway in MC3T3-E1 osteoblasts. J Bone Miner Res. 19:1181–1190. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Song G, Ouyang G and Bao S: The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med. 9:59–71. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Kennedy SG, Wagner AJ, Conzen SD, et al: The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev. 11:701–713. 1997. View Article : Google Scholar : PubMed/NCBI

42 

Scher HI and Sawyers CL: Biology of progressive, castration-resistant prostate cancer: Directed therapies targeting the androgen-receptor signaling axis. J Clin Oncol. 23:8253–8261. 2005. View Article : Google Scholar : PubMed/NCBI

43 

Niu Y, Chang TM, Yeh S, Ma WL, Wang YZ and Chang C: Differential androgen receptor signals in different cells explain why androgen-deprivation therapy of prostate cancer fails. Oncogene. 29:3593–3604. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hsieh T, Chen C, Yu A, Ma W, Zhang C, Shyr C and Chang C: Androgen receptor decreases the cytotoxic effects of chemotherapeutic drugs in upper urinary tract urothelial carcinoma cells. Oncol Lett 5: 1325-1330, 2013.
APA
Hsieh, T., Chen, C., Yu, A., Ma, W., Zhang, C., Shyr, C., & Chang, C. (2013). Androgen receptor decreases the cytotoxic effects of chemotherapeutic drugs in upper urinary tract urothelial carcinoma cells. Oncology Letters, 5, 1325-1330. https://doi.org/10.3892/ol.2013.1140
MLA
Hsieh, T., Chen, C., Yu, A., Ma, W., Zhang, C., Shyr, C., Chang, C."Androgen receptor decreases the cytotoxic effects of chemotherapeutic drugs in upper urinary tract urothelial carcinoma cells". Oncology Letters 5.4 (2013): 1325-1330.
Chicago
Hsieh, T., Chen, C., Yu, A., Ma, W., Zhang, C., Shyr, C., Chang, C."Androgen receptor decreases the cytotoxic effects of chemotherapeutic drugs in upper urinary tract urothelial carcinoma cells". Oncology Letters 5, no. 4 (2013): 1325-1330. https://doi.org/10.3892/ol.2013.1140
Copy and paste a formatted citation
x
Spandidos Publications style
Hsieh T, Chen C, Yu A, Ma W, Zhang C, Shyr C and Chang C: Androgen receptor decreases the cytotoxic effects of chemotherapeutic drugs in upper urinary tract urothelial carcinoma cells. Oncol Lett 5: 1325-1330, 2013.
APA
Hsieh, T., Chen, C., Yu, A., Ma, W., Zhang, C., Shyr, C., & Chang, C. (2013). Androgen receptor decreases the cytotoxic effects of chemotherapeutic drugs in upper urinary tract urothelial carcinoma cells. Oncology Letters, 5, 1325-1330. https://doi.org/10.3892/ol.2013.1140
MLA
Hsieh, T., Chen, C., Yu, A., Ma, W., Zhang, C., Shyr, C., Chang, C."Androgen receptor decreases the cytotoxic effects of chemotherapeutic drugs in upper urinary tract urothelial carcinoma cells". Oncology Letters 5.4 (2013): 1325-1330.
Chicago
Hsieh, T., Chen, C., Yu, A., Ma, W., Zhang, C., Shyr, C., Chang, C."Androgen receptor decreases the cytotoxic effects of chemotherapeutic drugs in upper urinary tract urothelial carcinoma cells". Oncology Letters 5, no. 4 (2013): 1325-1330. https://doi.org/10.3892/ol.2013.1140
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team