Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April 2013 Volume 5 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April 2013 Volume 5 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

CD146 is a potential marker for the diagnosis of malignancy in cervical and endometrial cancer

  • Authors:
    • Haofeng Zhang
    • Jun Zhang
    • Zhaoqing Wang
    • Di Lu
    • Jing Feng
    • Dongling Yang
    • Xiuqin Chen
    • Xiyun Yan
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Capital Medical University Affiliated Beijing Anzhen Hospital, Institute of Beijing Heart, Lung and Blood Vessel Diseases, Chaoyang, Beijing 100029, P.R. China, Protein and Peptide Pharmaceutical Laboratory, Chinese Academy of Sciences-University of Tokyo Joint Laboratory of Structural Virology and Immunology, Institute of Biophysics, Chinese Academy of Sciences, Chaoyang, Beijing 100101, P.R. China, Department of Obstetrics and Gynecology, The Fifth Affiliated Hospital of Zhengzhou University, Erqi, Zhengzhou 450000, P.R. China
  • Pages: 1189-1194
    |
    Published online on: January 22, 2013
       https://doi.org/10.3892/ol.2013.1147
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cluster of differentiation 146 (CD146) is an endothelial cell adhesion molecule which is overexpressed in various types of malignant cancer, including ovarian cancer. However, whether CD146 is overexpressed in another two types of gynecological cancer, cervical cancer and endometrial cancer, remains unclear. In the present study, we showed that CD146 expression levels were higher in cells from cervical cancer and endometrial cancer compared with their corresponding normal tissues, using anti-CD146 mouse antibody AA4 (mAb AA4) and that mAb AA4 exhibited a high performance for specificity, sensitivity and positive predictive value in the detection of these two types of cancer. CD146 expression was positively and significantly correlated with the pathological subtype of cervical cancer and with the histological grade and depth of myometrial invasion in endometrial cancer. In addition, we confirmed that CD146 is present in the majority of blood vessels in cervical and endometrial cancer, suggesting that CD146 may be actively implicated in the metastasis of cervical and endometrial cancer via the vascular system. Thus, this study provides insights for further development of CD146 mAb in the detection of gynecological malignant cancer types and implies that a combined treatment strategy of anti-CD146 immunotherapy with other traditional chemo- or radiotherapy treatments may be a promising approach against cervical and endometrial cancer.
View Figures

Figure 1

Figure 2

View References

1 

Lehmann JM, Holzmann B, Breitbart EW, Schmiegelow P, Riethmüller G and Johnson JP: Discrimination between benign and malignant cells of melanocytic lineage by two novel antigens, a glycoprotein with a molecular weight of 113,000 and a protein with a molecular weight of 76,000. Cancer Res. 47:841–845. 1987.

2 

Lehmann JM, Riethmüller G and Johnson JP: MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily. Proc Natl Acad Sci USA. 86:9891–9895. 1989. View Article : Google Scholar

3 

Shih IM, Elder DE, Speicher D, Johnson JP and Herlyn M: Isolation and functional characterization of the A32 melanoma-associated antigen. Cancer Res. 54:2514–2520. 1994.PubMed/NCBI

4 

Shih IM, Elder DE, Hsu MY and Herlyn M: Regulation of Mel-CAM/MUC18 expression on melanocytes of different stages of tumor progression by normal keratinocytes. Am J Pathol. 145:837–845. 1994.PubMed/NCBI

5 

Bardin N, Francès V, Lesaule G, Horschowski N, George F and Sampol J: Identification of the S-Endo 1 endothelial-associated antigen. Biochem Biophys Res Commun. 218:210–216. 1996. View Article : Google Scholar : PubMed/NCBI

6 

Rummel MM, Sers C and Johnson JP: Phorbol ester and cyclic AMP-mediated regulation of the melanoma-associated cell adhesion molecule MUC18/MCAM. Cancer Res. 56:2218–2223. 1996.PubMed/NCBI

7 

Xie S, Luca M, Huang S, et al: Expression of MCAM/MUC18 by human melanoma cells leads to increased tumor growth and metastasis. Cancer Res. 57:2295–2303. 1997.PubMed/NCBI

8 

Wu GJ, Wu MW, Wang C and Liu Y: Enforced expression of METCAM/MUC18 increases tumorigenesis of human prostate cancer LNCaP cells in nude mice. J Urol. 185:1504–1512. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Vainio O, Dunon D, Aïssi F, Dangy JP, McNagny KM and Imhof BA: HEMCAM, an adhesion molecule expressed by c-kit+ hemopoietic progenitors. J Cell Biol. 135:1655–1668. 1996.PubMed/NCBI

10 

Taira E, Takaha N, Taniura H, Kim CH and Miki N: Molecular cloning and functional expression of gicerin, a novel cell adhesion molecule that binds to neurite outgrowth factor. Neuron. 12:861–872. 1994. View Article : Google Scholar : PubMed/NCBI

11 

Aldovini D, Demichelis F, Doglioni C, et al: M-CAM expression as marker of poor prognosis in epithelial ovarian cancer. Int J Cancer. 119:1920–1926. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Feng G, Fang F, Liu C, Zhang F, Huang H and Pu C: CD146 gene expression in clear cell renal cell carcinoma: a potential marker for prediction of early recurrence after nephrectomy. Int Urol Nephrol. 44:1663–1669. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Liu WF, Ji SR, Sun JJ, et al: CD146 Expression Correlates with Epithelial-Mesenchymal Transition Markers and a Poor Prognosis in Gastric Cancer. Int J Mol Sci. 13:6399–6406. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Zeng Q, Li W, Lu D, et al: CD146, an epithelial-mesenchymal transition inducer, is associated with triple-negative breast cancer. Proc Natl Acad Sci USA. 109:1127–1132. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Ouhtit A, Gaur RL, Abd Elmageed ZY, et al: Towards understanding the mode of action of the multifaceted cell adhesion receptor CD146. Biochim Biophys Acta. 1795:130–136. 2009.PubMed/NCBI

16 

Bu P, Gao L, Zhuang J, Feng J, Yang D and Yan X: Anti-CD146 monoclonal antibody AA98 inhibits angiogenesis via suppression of nuclear factor-kappaB activation. Mol Cancer Ther. 5:2872–2878. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Wellbrock J and Fiedler W: CD146: a new partner for VEGFR2. Blood. 120:2164–2165. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Johnson JP, Rothbächer U and Sers C: The progression associated antigen MUC18: a unique member of the immunoglobulin supergene family. Melanoma Res. 3:337–340. 1993. View Article : Google Scholar : PubMed/NCBI

19 

Zhang Y, Zheng C, Zhang J, et al: Generation and characterization of a panel of monoclonal antibodies against distinct epitopes of human CD146. Hybridoma (Larchmt). 27:345–352. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Mathew A and George PS: Trends in incidence and mortality rates of squamous cell carcinoma and adenocarcinoma of cervix - worldwide. Asian Pac J Cancer Prev. 10:645–650. 2009.PubMed/NCBI

21 

Prat J: Prognostic parameters of endometrial carcinoma. Hum Pathol. 35:649–662. 2004. View Article : Google Scholar

22 

Kang Y, Wang F, Feng J, et al: Knockdown of CD146 reduces the migration and proliferation of human endothelial cells. Cell Res. 16:313–318. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Zheng C, Qiu Y, Zeng Q, et al: Endothelial CD146 is required for in vitro tumor-induced angiogenesis: the role of a disulfide bond in signaling and dimerization. Int J Biochem Cell Biol. 41:2163–2172. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar

25 

Nolen BM and Lokshin AE: Protein biomarkers of ovarian cancer: the forest and the trees. Future Oncol. 8:55–71. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Tanyi JL and Scholler N: Oncology biomarkers for gynecologic malignancies. Front Biosci (Elite Ed). 4:1097–1110. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Chmura A, Wojcieszek A, Mrochem J, et al: Usefulness of the SCC, CEA, CYFRA 21.1, and CRP markers for the diagnosis and monitoring of cervical squamous cell carcinoma. Ginekol Pol. 80:361–366. 2009.(In Polish).

28 

Micke O, Bruns F, Schäfer U, Prott FJ and Willich N: The impact of squamous cell carcinoma (SCC) antigen in patients with advanced cancer of uterine cervix treated with (chemo-)radiotherapy. Anticancer Res. 25:1663–1666. 2005.PubMed/NCBI

29 

Jankovic MM and Milutinovic BS: Glycoforms of CA125 antigen as a possible cancer marker. Cancer Biomark. 4:35–42. 2008.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang H, Zhang J, Wang Z, Lu D, Feng J, Yang D, Chen X and Yan X: CD146 is a potential marker for the diagnosis of malignancy in cervical and endometrial cancer. Oncol Lett 5: 1189-1194, 2013.
APA
Zhang, H., Zhang, J., Wang, Z., Lu, D., Feng, J., Yang, D. ... Yan, X. (2013). CD146 is a potential marker for the diagnosis of malignancy in cervical and endometrial cancer. Oncology Letters, 5, 1189-1194. https://doi.org/10.3892/ol.2013.1147
MLA
Zhang, H., Zhang, J., Wang, Z., Lu, D., Feng, J., Yang, D., Chen, X., Yan, X."CD146 is a potential marker for the diagnosis of malignancy in cervical and endometrial cancer". Oncology Letters 5.4 (2013): 1189-1194.
Chicago
Zhang, H., Zhang, J., Wang, Z., Lu, D., Feng, J., Yang, D., Chen, X., Yan, X."CD146 is a potential marker for the diagnosis of malignancy in cervical and endometrial cancer". Oncology Letters 5, no. 4 (2013): 1189-1194. https://doi.org/10.3892/ol.2013.1147
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang H, Zhang J, Wang Z, Lu D, Feng J, Yang D, Chen X and Yan X: CD146 is a potential marker for the diagnosis of malignancy in cervical and endometrial cancer. Oncol Lett 5: 1189-1194, 2013.
APA
Zhang, H., Zhang, J., Wang, Z., Lu, D., Feng, J., Yang, D. ... Yan, X. (2013). CD146 is a potential marker for the diagnosis of malignancy in cervical and endometrial cancer. Oncology Letters, 5, 1189-1194. https://doi.org/10.3892/ol.2013.1147
MLA
Zhang, H., Zhang, J., Wang, Z., Lu, D., Feng, J., Yang, D., Chen, X., Yan, X."CD146 is a potential marker for the diagnosis of malignancy in cervical and endometrial cancer". Oncology Letters 5.4 (2013): 1189-1194.
Chicago
Zhang, H., Zhang, J., Wang, Z., Lu, D., Feng, J., Yang, D., Chen, X., Yan, X."CD146 is a potential marker for the diagnosis of malignancy in cervical and endometrial cancer". Oncology Letters 5, no. 4 (2013): 1189-1194. https://doi.org/10.3892/ol.2013.1147
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team