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Article

The clinical and prognostic implications of pluripotent stem cell gene expression in hepatocellular carcinoma

  • Authors:
    • Xin Yin
    • Yi-Wei Li
    • Jian-Jun Jin
    • Yin Zhou
    • Zheng-Gang Ren
    • Shuang-Jian Qiu
    • Bo-Heng Zhang
  • View Affiliations / Copyright

    Affiliations: Liver Cancer Institute and Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai 200032, P.R. China, Experimental Center of Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China
  • Pages: 1155-1162
    |
    Published online on: January 23, 2013
       https://doi.org/10.3892/ol.2013.1151
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Abstract

Recently, growing evidence has demonstrated that aberrant expression of pluripotent stem cell-related genes may confer primitive and aggressive traits and be associated with unfavorable clinical outcomes in certain solid cancers. However, the role of pluripotent stem cell gene expression in hepatocellular carcinoma (HCC) remains unexplored. We evaluated the expression of the pluri­potent stem cell genes Oct4, Sox2 and Klf4, as well as that of the c-Myc, Nanog and Lin28 genes in HCC samples and corresponding adjacent non-tumor liver samples obtained from 57 patients using quantitative real-time reverse transcription-PCR (qRT-PCR). The results revealed that six pluripotent stem cell gene expression levels were upregulated in the tumor tissues compared with the corresponding adjacent non-tumor liver tissues. In HCC tissues, aberrant expression of Sox2 and Lin28 was associated with a large tumor size (P=0.02 and P=0.03, respectively), while increased expression levels of c-Myc (P=0.01) were correlated with vascular invasion. Moreover, high Klf4 expression levels were associated with aggressive tumor behaviors in terms of vascular invasion (P=0.02) and poor tumor differentiation (P=0.03). Survival analysis revealed that Klf4 expression was independently associated with overall survival [OS; hazard ratio (HR), 8.61; 95% confidential interval (CI), 2.7-27.5; P<0.001] and recurrence‑free survival (RFS; HR, 3.96; 95% CI, 1.3-11.6; P=0.01). In conclusion, pluripotent stem cell genes are associated with HCC progression and a poor prognosis. The development of therapeutic strategies, including adjuvant therapy, that take cancer stem cell (CSC)-related markers into consideration is likely to be a key factor in further improvements of the prognosis of HCC patients undergoing curative liver resection.
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1 

Yang ZF, Ngai P, Ho DW, Yu WC, Ng MN, Lau CK, Li ML, Tam KH, Lam CT, Poon RT and Fan ST: Identification of local and circulating cancer stem cells in human liver cancer. Hepatology. 47:919–928. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Pardal R, Clarke MF and Morrison SJ: Applying the principles of stem-cell biology to cancer. Nat Rev Cancer. 3:895–902. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Rossi DJ and Weissman IL: Pten, tumorigenesis, and stem cell self-renewal. Cell. 125:229–231. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Widschwendter M, Fiegl H, Egle D, Mueller-Holzner E, Spizzo G, Marth C, Weisenberger DJ, Campan M, Young J, Jacobs I and Laird PW: Epigenetic stem cell signature in cancer. Nat Genet. 39:157–158. 2007. View Article : Google Scholar

5 

Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A and Weinberg RA: An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet. 40:499–507. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Wong DJ, Liu H, Ridky TW, Cassarino D, Segal E and Chang HY: Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell. 2:333–344. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Takahashi K and Yamanaka S: Induction of pluripotent stem cells from mouse embryonic and adult firoblast cultures by defined factors. Cell. 126:663–676. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R, Slukvin II and Thomson JA: Induced pluripotent stem cell lines derived from human somatic cells. Science. 318:1917–1920. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Rodini CO, Suzuki DE, Saba-Silva N, Cappellano A, de Souza JE, Cavalheiro S, Toledo SR and Okamoto OK: Expression analysis of stem cell-related genes reveal OCT4 as a predictor of poor clinical outcome in medulloblastoma. J Neurooncol. 106:71–79. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Saiki Y, Ishimaru S, Mimori K, Takatsuno Y, Nagahara M, Ishii H, Yamada K and Mori M: Comprehensive analysis of the clinical significance of inducing pluripotent stemness-related gene expression in colorectal cancer cells. Ann Surg Oncol. 16:2638–2644. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Sun HC, Zhang W, Qin LX, Zhang BH, Ye QH, Wang L, Ren N, Zhuang PY, Zhu XD, Fan J and Tang ZY: Positive serum hepatitis B e antigen is associated with higher risk of early recurrence and poorer survival in patients after curative resection of hepatitis B-related hepatocellular carcinoma. J Hepatol. 47:684–690. 2007. View Article : Google Scholar

12 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Yang XR, Xu Y, Shi GM, Fan J, Zhou J, Ji Y, Sun HC, Qiu SJ, Yu B, Gao Q, He YZ, et al: Cytokeratin 10 and cytokeratin 19: predictive markers for poor prognosis in hepatocellular carcinoma patients after curative resection. Clin Cancer Res. 14:3850–3859. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Sun HC, Zhuang PY, Qin LX, Ye QH, Wang L, Ren N, Zhang JB, Qian YB, Lu L, Fan J and Tang ZY: Incidence and prognostic values of lymph node metastasis in operable hepatocellular carcinoma and evaluation of routine complete lymphadenectomy. J Surg Oncol. 96:37–45. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Raeside DE: Monte Carlo principles and applications. Phys Med Biol. 21:181–197. 1976. View Article : Google Scholar : PubMed/NCBI

16 

Evans PM and Liu C: Roles of Krüpel-like factor 4 in normal homeostasis, cancer and stem cells. Acta Biochim Biophys Sin. 40:554–564. 2008.

17 

Zhou Y, Hofstetter WL, He Y, Hu W, Pataer A, Wang L, Wang J, Zhou Y, Yu L, Fang B and Swisher SG: KLF4 inhibition of lung cancer cell invasion by suppression of SPARC expression. Cancer Biol Ther. 9:507–513. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Zammarchi F, Morelli M, Menicagli M, Di Cristofano C, Zavaglia K, Paolucci A, Campani D, Aretini P, Boggi U, Mosca F, Cavazzana A, et al: KLF4 is a novel candidate tumor suppressor gene in pancreatic ductal carcinoma. Am J Pathol. 178:361–372. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Pandya AY, Talley LI, Frost AR, Fitzgerald TJ, Trivedi V, Chakravarthy M, Chhieng DC, Grizzle WE, Engler JA, Krontiras H, Bland KI, LoBuglio AF, Lobo-Ruppert SM and Ruppert JM: Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancer. Clin Cancer Res. 10:2709–2719. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Foster KW, Liu Z, Nail CD, Li X, Fitzgerald TJ, Bailey SK, Frost AR, Louro ID, Townes TM, Paterson AJ, Kudlow JE, et al: Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia. Oncogene. 24:1491–1500. 2005. View Article : Google Scholar

21 

Chen YJ, Wu CY, Chang CC, Ma CJ, Li MC and Chen CM: Nuclear Krüppel-like factor 4 expression is associated with human skin squamous cell carcinoma progression and metastasis. Cancer Biol Ther. 7:777–782. 2008.

22 

Fong H, Hohenstein KA and Donovan PJ: Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells. Stem Cells. 26:1931–1938. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Hussenet T, Dali S, Exinger J, Monga B, Jost B, Dembelé D, Martinet N, Thibault C, Huelsken J, Brambilla E and du Manoir S: Sox2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas. PLoS One. 5:e89602010. View Article : Google Scholar : PubMed/NCBI

24 

Chen Y, Shi L, Zhang L, Li R, Liang J, Yu W, Sun L, Yang X, Wang Y, Zhang Y and Shang Y: The molecular mechanism governing the oncogenic potential of Sox2 in breast cancer. J Biol Chem. 283:17969–17978. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Gangemi RM, Griffero F, Marubbi D, Perera M, Capra MC, Malatesta P, Ravetti GL, Zona GL, Daga A and Corte G: Sox2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity. Stem Cells. 27:40–48. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Sanada Y, Yoshida K, Ohara M, Oeda M, Konishi K and Tsutani Y: Histopathologic evaluation of stepwise progression of pancreatic carcinoma with immunohistochemical analysis of gastric epithelial transcription factor Sox2: comparison of expression patterns between invasive components and cancerous or nonneoplastic intraductal components. Pancreas. 32:164–170. 2006.

27 

Nichols J, Zevnik B, Anastassiadis K, Niwa H, Klewe-Nebenius D, Chambers I, Schöler H and Smith A: Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell. 95:379–391. 1998. View Article : Google Scholar : PubMed/NCBI

28 

Chambers I, Colby D, Robertson M, Nichols J, Lee S, Tweedie S and Smith A: Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell. 113:643–655. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Chang CC: Recent translational research: stem cells as the roots of breast cancer. Breast Cancer Res. 8:1032006. View Article : Google Scholar : PubMed/NCBI

30 

Du Z, Jia D, Liu S, Wang F, Li G, Zhang Y, Cao X, Ling EA and Hao A: Oct4 is expressed in human gliomas and promotes colony formation in glioma cells. Glia. 57:724–733. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Zhou X, Zhou YP, Huang GR, Gong BL, Yang B, Zhang DX, Hu P and Xu SR: Expression of the stem cell marker, Nanog, in human endometrial adenocarcinoma. Int J Gynecol Pathol. 30:262–270. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Lin T, Ding YQ and Li JM: Overexpression of Nanog protein is associated with poor prognosis in gastric adenocarcinoma. Med Oncol. 29:878–885. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Meng HM, Zheng P, Wang XY, Liu C, Sui HM, Wu SJ, Zhou J, Ding YQ and Li JM: Overexpression of Nanog predicts tumor progression and poor prognosis in colorectal cancer. Cancer Biol Ther. 9:295–302. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Wen J, Park JY, Park KH, Chung HW, Bang S, Park SW and Song SY: Oct4 and Nanog expression is associated with early stages of pancreatic carcinogenesis. Pancreas. 39:622–626. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Chiou SH, Yu CC, Huang CY, Lin SC, Liu CJ, Tsai TH, Chou SH, Chien CS, Ku HH and Lo JF: Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma. Clin Cancer Res. 14:4085–4095. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Grandori C, Cowley SM, James LP and Eisenman RN: The Myc/Max/Mad network and the transcriptional control of cell behavior. Annu Rev Cell Dev Biol. 16:653–699. 2000. View Article : Google Scholar : PubMed/NCBI

37 

Ma L, Young J, Prabhala H, Pan E, Mestdagh P, Muth D, Teruya-Feldstein J, Reinhardt F, Onder TT, Valastyan S, Westermann F, et al: miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol. 12:247–256. 2010.PubMed/NCBI

38 

Rapp UR, Korn C, Ceteci F, Karreman C, Luetkenhaus K, Serafin V, Zanucco E, Castro I and Potapenko T: MYC is a metastasis gene for non-small-cell lung cancer. PLoS One. 4:e60292009. View Article : Google Scholar : PubMed/NCBI

39 

Dominguez-Sola D, Ying CY, Grandori C, Ruggiero L, Chen B, Li M, Galloway DA, Gu W, Gautier J and Dalla-Favera R: Non-transcriptional control of DNA replication by c-Myc. Nature. 448:445–451. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Soucek L, Lawlor ER, Soto D, Shchors K, Swigart LB and Evan GI: Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors. Nat Med. 13:1211–1218. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Dangi-Garimella S, Yun J, Eves EM, Newman M, Erkeland SJ, Hammond SM, Minn AJ and Rosner MR: Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7. EMBO J. 28:347–358. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Hamano R, Miyata H, Yamasaki M, Sugimura K, Tanaka K, Kurokawa Y, Nakajima K, Takiguchi S, Fujiwara Y, Mori M and Doki Y: High expression of Lin28 is associated with tumour aggressiveness and poor prognosis of patients in oesophagus cancer. Br J Cancer. 106:1415–1423. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yin X, Li Y, Jin J, Zhou Y, Ren Z, Qiu S and Zhang B: The clinical and prognostic implications of pluripotent stem cell gene expression in hepatocellular carcinoma. Oncol Lett 5: 1155-1162, 2013.
APA
Yin, X., Li, Y., Jin, J., Zhou, Y., Ren, Z., Qiu, S., & Zhang, B. (2013). The clinical and prognostic implications of pluripotent stem cell gene expression in hepatocellular carcinoma. Oncology Letters, 5, 1155-1162. https://doi.org/10.3892/ol.2013.1151
MLA
Yin, X., Li, Y., Jin, J., Zhou, Y., Ren, Z., Qiu, S., Zhang, B."The clinical and prognostic implications of pluripotent stem cell gene expression in hepatocellular carcinoma". Oncology Letters 5.4 (2013): 1155-1162.
Chicago
Yin, X., Li, Y., Jin, J., Zhou, Y., Ren, Z., Qiu, S., Zhang, B."The clinical and prognostic implications of pluripotent stem cell gene expression in hepatocellular carcinoma". Oncology Letters 5, no. 4 (2013): 1155-1162. https://doi.org/10.3892/ol.2013.1151
Copy and paste a formatted citation
x
Spandidos Publications style
Yin X, Li Y, Jin J, Zhou Y, Ren Z, Qiu S and Zhang B: The clinical and prognostic implications of pluripotent stem cell gene expression in hepatocellular carcinoma. Oncol Lett 5: 1155-1162, 2013.
APA
Yin, X., Li, Y., Jin, J., Zhou, Y., Ren, Z., Qiu, S., & Zhang, B. (2013). The clinical and prognostic implications of pluripotent stem cell gene expression in hepatocellular carcinoma. Oncology Letters, 5, 1155-1162. https://doi.org/10.3892/ol.2013.1151
MLA
Yin, X., Li, Y., Jin, J., Zhou, Y., Ren, Z., Qiu, S., Zhang, B."The clinical and prognostic implications of pluripotent stem cell gene expression in hepatocellular carcinoma". Oncology Letters 5.4 (2013): 1155-1162.
Chicago
Yin, X., Li, Y., Jin, J., Zhou, Y., Ren, Z., Qiu, S., Zhang, B."The clinical and prognostic implications of pluripotent stem cell gene expression in hepatocellular carcinoma". Oncology Letters 5, no. 4 (2013): 1155-1162. https://doi.org/10.3892/ol.2013.1151
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