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Article

Arachidonic acid supplementation does not affect N-methyl-N-nitrosourea-induced renal preneoplastic lesions in young Lewis rats

  • Authors:
    • Katsuhiko Yoshizawa
    • Yuko Emoto
    • Yuichi Kinoshita
    • Ayako Kimura
    • Norihisa Uehara
    • Takashi Yuri
    • Nobuaki Shikata
    • Tomohito Hamazaki
    • Airo Tsubura
  • View Affiliations / Copyright

    Affiliations: Department of Pathology II, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan, Division of Pathology, Kansai Medical University Takii Hospital, Moriguchi, Osaka 570-8507, Japan, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan
  • Pages: 1112-1116
    |
    Published online on: January 30, 2013
       https://doi.org/10.3892/ol.2013.1162
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Abstract

Arachidonic acid (AA) is naturally found in human breast milk. AA, together with docosahexaenoic acid, is commonly added as a functional food ingredient to commercial infant formula worldwide, in accordance with the international standards of Codex Alimentarius. However, few studies of the possible renal carcinogenic effects of AA supplementation during neonatal life have been performed. The effect of dietary AA supplementation in dams during gestation and lactation was investigated on N-methyl-N-nitrosourea (MNU)-induced preneoplastic lesions in the kidneys of young Lewis rats. Dams were fed a 2.0% AA diet or a basal diet (<0.01% AA). At birth (postnatal day 0), male and female pups received a single intraperitoneal injection of 35 mg/kg MNU or vehicle. Renal morphology was examined after 7, 14, 21, 28 and 60 days. Histopathologically, renal preneoplastic lesions, such as nephroblastomatosis and mesenchymal cell proliferation, were found on day 60 in both the MNU-treated groups. There was no significant difference in lesion incidence of 38% in the basal diet group and 31% in the AA diet group. In conclusion, an AA-rich diet for dams during gestation and lactation does not modify MNU-induced renal preneoplastic lesions in their offspring.
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View References

1 

World Health Organization, International Agency for Research on Cancer (WHO IARC): Kidney cancer. World Cancer Report. Stewart BW and Kleihues P: IARC Press; Lyon: pp. 261–264. 2003

2 

Davidoff AM: Wilms tumor. Curr Opin Pediatr. 21:357–364. 2009. View Article : Google Scholar

3 

Kimura A, Yoshizawa K, Sasaki T, Uehara N, Kinoshita Y, Miki H, Yuri T, Uchida T and Tsubura A: N-methyl-N-nitrosourea-induced changes in epithelial rests of Malassez and the development of odontomas in rats. Exp Ther Med. 4:15–20. 2012.

4 

Tsubura A, Lai YC, Miki H, Sasaki T, Uehara N, Yuri T and Yoshizawa K: Animal models of N-methyl-N-nitrosourea-induced mammary cancer and retinal degeneration with special emphasis on therapeutic trials. In Vivo. 25:11–22. 2011.

5 

Yoshizawa K, Uehara N, Kimura A, Emoto Y, Kinoshita Y, Yuri T, Takada H, Moriguchi T, Hamazaki T and Tsubura A: Promoting effect of arachidonic acid supplementation on N-methyl-N-nitrosourea-induced pancreatic acinar cell hyper-plasia in young Lewis rats. Oncol Lett. 5:76–82. 2013.PubMed/NCBI

6 

Warzok R, Schreiber D and Blaufuss EM: Tumors of the rat kidney induced by nitrosourea compounds. Exp Path. 17:394–402. 1979.PubMed/NCBI

7 

Hard GC: Experimental models for the sequential analysis of chemically-induced renal carcinogenesis. Toxicol Pathol. 14:112–122. 1986. View Article : Google Scholar : PubMed/NCBI

8 

Hard GC: Mechanisms of chemically induced renal carcinogenesis in the laboratory rodent. Toxicol Pathol. 26:104–112. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Turusov VS, Alexandrov VA and Timoshenko IV: Nephroblastoma and renal mesenchymal tumor induced in rats by N-nitrosoethyl- and N-nitrosomethylurea. Neoplasma. 27:229–235. 1980.PubMed/NCBI

10 

Sharma PM, Bowman M, Yu BF and Sukumar S: A rodent model for Wilms tumors: embryonal kidney neoplasms induced by N-nitroso-N-methylurea. Proc Natl Acad Sci, USA. 91:9931–9935. 1994. View Article : Google Scholar : PubMed/NCBI

11 

Davis-Bruno K and Tassinari MS: Essential fatty acid supplementation of DHA and ARA and effects on neurodevelopment across animal species: a review of the literature. Birth Defects Res (Part B). 92:240–250. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Le HD, Meisel JA, de Meijer VE, Gura KM and Puder M: The essentiality of arachidonic acid and docosahexaenoic acid. Prostaglandins Leukot Essent Fatty Acids. 81:165–170. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Codex Alimentarius Commission, Joint FAO/WHO Food Standards Programme: Report of the 28th Session of the Codex Committee on Nutrition and Foods for Special Dietary Uses. 2007.

14 

Gleissman H, Johnsen JI and Kogner P: Omega-3 fatty acids in cancer, the protectors of good and the killers of evil? Exp Cell Res. 316:1365–1373. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Hamazaki T: Reports on Research on the toxicity of arachidonic acid supplementation. The Health and Labor Sciences Research Grants, Japan (H22-Shokuhin-Ippan-002),. 2012.(in Japanese).

16 

Hashimoto Y, Kondo Y, Kimura G, Matsuzawa I, Sato S, Ishizaki M, Imura N, Akimoto M and Hara S: Cyclooxygenase-2 expression and relationship to tumour progression in human renal cell carcinoma. Histopathology. 44:353–359. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Matsuyama M and Yoshimura R: Relationship between arachidonic acid pathway and human renal carcinoma. Onco Targets and Therapy. 1:41–48. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Calo L, Cantaro S, Bertazzo L, Vianello A, Vido L and Borsatti A: Synthesis and catabolism of PGE2 by a nephroblastoma associated with hypercalcemia without bone metastases. Cancer. 54:635–637. 1984. View Article : Google Scholar : PubMed/NCBI

19 

Calo L, Cantaro S, Vianello A, Vido L, Rizzoni G and Borsatti A: Arachidonic acid metabolites in a nephroblastoma associated with paraneoplastic hypercalcemia. Prostaglandins. 32:116–120. 1986. View Article : Google Scholar : PubMed/NCBI

20 

Frazier KS, Seely JC, Hard GC, Betton G, Burnett R, Nakatsuji S, Nishikawa A, Durchfeld-Meyer B and Bube A: Proliferative and nonproliferative lesions of rat and mouse urinary system. Toxicol Pathol. 40:14S–86S. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Mitsumori K, Yoshida M, Iwata H, Katsuda O, Kouchi M and Tsuda H: Classification of renal proliferative lesions in rats and/or mice and their diagnostic problems: report from the working group of the Japanese Society of Toxicologic Pathology. J Toxicol Pathol. 15:175–190. 2002. View Article : Google Scholar

22 

Frank AA, Heidel JR, Thompson DJ, Carlton WW and Beckwith JB: Renal transplacental carcinogenicity of 3,3-dimethyl-phenyltriazene in rats: relationship of renal mesenchymal tumor to congenital mesoblastic nephroma and intralobar nephrogenic rests. Toxicol Pathol. 20:313–322. 1992.

23 

Klalaiselvan P, Mathur KY, Pande VV, Madheswaran R, Bhelonde JJ, Shelar PD, Udupa V and Shingatgeri VM: Intralobar nephroblastomatosis in a nine-week-old Wistar rat. Toxicol Pathol. 37:819–825. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Seely JC: Renal mesenchymal tumor vs nephroblastoma: revised. J Toxicol Pathol. 17:131–136. 2004. View Article : Google Scholar

25 

Deshpande RB and Hasgekar NN: Rat renal mesenchymal tumor as an experimental model for human congenital mesoblastic nephroma: II. Comparative pathology. Pediatr Pathol. 9:141–151. 1989. View Article : Google Scholar

26 

Hasgekar NN, Pendse AM and Lalitha VS: Rat renal mesenchymal tumor as an experimental model for human congenital mesoblastic nephroma: I. Induction. Pediatr Pathol. 9:131–139. 1989. View Article : Google Scholar : PubMed/NCBI

27 

Bunin GR: Nongenetic causes of childhood cancers: evidence from international variation, time trends, and risk factor studies. Toxicol Appl Pharmacol. 199:91–103. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Zahm SH and Ward MH: Pesticides and childhood cancer. Environ Health Perspect. 106:893–908. 1998. View Article : Google Scholar

29 

Imai N, Kawabe M, Tamano S, Doi Y, Nakashima H, Suguro M, Numano T, Hara T, Hagiwara A, Furukawa F, Kaneda Y, Tateishi N, Fujii W, Kawashima H, Shibata H and Sakakibara Y: Arachidonate-enriched triglyceride oil does not promote tumor development in a rat medium-term multi-organ carcinogenesis model. Food Chem Toxicol. 50:2780–2791. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yoshizawa K, Emoto Y, Kinoshita Y, Kimura A, Uehara N, Yuri T, Shikata N, Hamazaki T and Tsubura A: Arachidonic acid supplementation does not affect N-methyl-N-nitrosourea-induced renal preneoplastic lesions in young Lewis rats. Oncol Lett 5: 1112-1116, 2013.
APA
Yoshizawa, K., Emoto, Y., Kinoshita, Y., Kimura, A., Uehara, N., Yuri, T. ... Tsubura, A. (2013). Arachidonic acid supplementation does not affect N-methyl-N-nitrosourea-induced renal preneoplastic lesions in young Lewis rats. Oncology Letters, 5, 1112-1116. https://doi.org/10.3892/ol.2013.1162
MLA
Yoshizawa, K., Emoto, Y., Kinoshita, Y., Kimura, A., Uehara, N., Yuri, T., Shikata, N., Hamazaki, T., Tsubura, A."Arachidonic acid supplementation does not affect N-methyl-N-nitrosourea-induced renal preneoplastic lesions in young Lewis rats". Oncology Letters 5.4 (2013): 1112-1116.
Chicago
Yoshizawa, K., Emoto, Y., Kinoshita, Y., Kimura, A., Uehara, N., Yuri, T., Shikata, N., Hamazaki, T., Tsubura, A."Arachidonic acid supplementation does not affect N-methyl-N-nitrosourea-induced renal preneoplastic lesions in young Lewis rats". Oncology Letters 5, no. 4 (2013): 1112-1116. https://doi.org/10.3892/ol.2013.1162
Copy and paste a formatted citation
x
Spandidos Publications style
Yoshizawa K, Emoto Y, Kinoshita Y, Kimura A, Uehara N, Yuri T, Shikata N, Hamazaki T and Tsubura A: Arachidonic acid supplementation does not affect N-methyl-N-nitrosourea-induced renal preneoplastic lesions in young Lewis rats. Oncol Lett 5: 1112-1116, 2013.
APA
Yoshizawa, K., Emoto, Y., Kinoshita, Y., Kimura, A., Uehara, N., Yuri, T. ... Tsubura, A. (2013). Arachidonic acid supplementation does not affect N-methyl-N-nitrosourea-induced renal preneoplastic lesions in young Lewis rats. Oncology Letters, 5, 1112-1116. https://doi.org/10.3892/ol.2013.1162
MLA
Yoshizawa, K., Emoto, Y., Kinoshita, Y., Kimura, A., Uehara, N., Yuri, T., Shikata, N., Hamazaki, T., Tsubura, A."Arachidonic acid supplementation does not affect N-methyl-N-nitrosourea-induced renal preneoplastic lesions in young Lewis rats". Oncology Letters 5.4 (2013): 1112-1116.
Chicago
Yoshizawa, K., Emoto, Y., Kinoshita, Y., Kimura, A., Uehara, N., Yuri, T., Shikata, N., Hamazaki, T., Tsubura, A."Arachidonic acid supplementation does not affect N-methyl-N-nitrosourea-induced renal preneoplastic lesions in young Lewis rats". Oncology Letters 5, no. 4 (2013): 1112-1116. https://doi.org/10.3892/ol.2013.1162
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