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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April 2013 Volume 5 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Younger patients with chronic lymphocytic leukemia benefit from rituximab treatment: A single center study in China

  • Authors:
    • Zhenshu Xu
    • Jinyan Zhang
    • Shunquan Wu
    • Zhihong Zheng
    • Zhizhe Chen
    • Rong Zhan
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Union Hospital of Fujian Medical University, Fuzhou, Fujian 350001, P.R. China
  • Pages: 1266-1272
    |
    Published online on: February 5, 2013
       https://doi.org/10.3892/ol.2013.1177
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Abstract

Chronic lymphocytic leukemia (CLL) is characterized by high heterogeneity in clinical features and outcomes in Western countries and China. In this study, the clinical and laboratory data of 210 CLL patients who were admitted to a single center in China between 2002 and 2011 were retrospectively analyzed. CLL patients had a median age of 60.2 years (range, 35-92 years) and CLL occurred more often in elderly female patients than in male patients (female:male, 1.2:1). The overall response rate [ORR, complete remission (CR) + partial remission (PR)] in the entire cohort of patients was 69.5% and the median overall survival (OS) was 67 months (95% CI, 57.88-76.11). In univariate analysis, an age of >60 years, chromosome 17p deletion (17p-) and elevated β2-MG were associated with a worse OS. Patients with all three poor prognostic factors had a worse outcome than patients with only one or two factors. Patients with 17p- had a significantly lower ORR (P=0.008) and shorter OS (P=0.001) than those without 17p-. Rituximab (R)-based treatment was able to overcome the poor prognosis associated with 17p-. Moreover, the addition of R to fludarabine (F) and cyclophosphamide (C) treatment significantly improved the OS (P=0.012) compared with FC alone in younger patients. However, there were no significant benefits for older patients (P=0.07). This implies that the age of a patient is important in their response to therapy and survival.
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Copy and paste a formatted citation
Spandidos Publications style
Xu Z, Zhang J, Wu S, Zheng Z, Chen Z and Zhan R: Younger patients with chronic lymphocytic leukemia benefit from rituximab treatment: A single center study in China. Oncol Lett 5: 1266-1272, 2013.
APA
Xu, Z., Zhang, J., Wu, S., Zheng, Z., Chen, Z., & Zhan, R. (2013). Younger patients with chronic lymphocytic leukemia benefit from rituximab treatment: A single center study in China. Oncology Letters, 5, 1266-1272. https://doi.org/10.3892/ol.2013.1177
MLA
Xu, Z., Zhang, J., Wu, S., Zheng, Z., Chen, Z., Zhan, R."Younger patients with chronic lymphocytic leukemia benefit from rituximab treatment: A single center study in China". Oncology Letters 5.4 (2013): 1266-1272.
Chicago
Xu, Z., Zhang, J., Wu, S., Zheng, Z., Chen, Z., Zhan, R."Younger patients with chronic lymphocytic leukemia benefit from rituximab treatment: A single center study in China". Oncology Letters 5, no. 4 (2013): 1266-1272. https://doi.org/10.3892/ol.2013.1177
Copy and paste a formatted citation
x
Spandidos Publications style
Xu Z, Zhang J, Wu S, Zheng Z, Chen Z and Zhan R: Younger patients with chronic lymphocytic leukemia benefit from rituximab treatment: A single center study in China. Oncol Lett 5: 1266-1272, 2013.
APA
Xu, Z., Zhang, J., Wu, S., Zheng, Z., Chen, Z., & Zhan, R. (2013). Younger patients with chronic lymphocytic leukemia benefit from rituximab treatment: A single center study in China. Oncology Letters, 5, 1266-1272. https://doi.org/10.3892/ol.2013.1177
MLA
Xu, Z., Zhang, J., Wu, S., Zheng, Z., Chen, Z., Zhan, R."Younger patients with chronic lymphocytic leukemia benefit from rituximab treatment: A single center study in China". Oncology Letters 5.4 (2013): 1266-1272.
Chicago
Xu, Z., Zhang, J., Wu, S., Zheng, Z., Chen, Z., Zhan, R."Younger patients with chronic lymphocytic leukemia benefit from rituximab treatment: A single center study in China". Oncology Letters 5, no. 4 (2013): 1266-1272. https://doi.org/10.3892/ol.2013.1177
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