HPV genotypes in paraffin sections of non-cervical squamous cell carcinoma in Qingdao of China

  • Authors:
    • Zhi Di Gao
    • Qi Pan
    • Hong Lv
    • Yang Sun
    • Xiaoye Ma
    • Zuorong Qin
    • Yu Ping Sun
  • View Affiliations

  • Published online on: February 6, 2013     https://doi.org/10.3892/ol.2013.1181
  • Pages: 1219-1222
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Abstract

Human papillomaviruses (HPVs) are the cause of cervical cancer and possibly a subset of squamous cell carcinomas (SCCs) in other sites. However, the prevalence and distribution of HPV subtypes remain unclear. In the present study, we collected and analyzed 511 paraffin sections of non‑cervical SCC from patients in Qingdao, China, for the presence of HPV using polymerase chain reaction (PCR). We identified that 55.77% (285/511) of the samples were positive for HPV infection. There was a significant association between HPV type and the different sites of SCC. An association between HPV-positive cases and tobacco, alcohol, age and tumor differentiation was demonstrated. The information provided by this study may be important for further investigation into the association between HPV and SCC. High-risk HPV subtypes were associated with the malignant degree of SCC. This study provided a theoretical basis for the preventative treatment of non-cervical SCC using HPV vaccines.
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April 2013
Volume 5 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Gao ZD, Pan Q, Lv H, Sun Y, Ma X, Qin Z and Sun YP: HPV genotypes in paraffin sections of non-cervical squamous cell carcinoma in Qingdao of China. Oncol Lett 5: 1219-1222, 2013
APA
Gao, Z.D., Pan, Q., Lv, H., Sun, Y., Ma, X., Qin, Z., & Sun, Y.P. (2013). HPV genotypes in paraffin sections of non-cervical squamous cell carcinoma in Qingdao of China. Oncology Letters, 5, 1219-1222. https://doi.org/10.3892/ol.2013.1181
MLA
Gao, Z. D., Pan, Q., Lv, H., Sun, Y., Ma, X., Qin, Z., Sun, Y. P."HPV genotypes in paraffin sections of non-cervical squamous cell carcinoma in Qingdao of China". Oncology Letters 5.4 (2013): 1219-1222.
Chicago
Gao, Z. D., Pan, Q., Lv, H., Sun, Y., Ma, X., Qin, Z., Sun, Y. P."HPV genotypes in paraffin sections of non-cervical squamous cell carcinoma in Qingdao of China". Oncology Letters 5, no. 4 (2013): 1219-1222. https://doi.org/10.3892/ol.2013.1181