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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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August 2013 Volume 6 Issue 2

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Case Report

Fluid biopsy for circulating tumor cells in an occult ovarian cancer patient exhibiting bilateral supraclavicular lymph node metastases: A case report

  • Authors:
    • Shizhi He
    • Pingdong Li
    • Xiaohong Chen
    • Zhenkun Yu
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology‑Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otolaryngology‑Head and Neck Surgery, Ministry of Education, Capital Medical University, Beijing 100730, P.R. China
  • Pages: 448-452
    |
    Published online on: May 24, 2013
       https://doi.org/10.3892/ol.2013.1364
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Abstract

Metastases to the supraclavicular region usually originate from the head and neck or from infraclavicular tumors. Ovarian primaries of supraclavicular metastases are extremely rare. The present study reports the case of a 60‑year‑old patient with a bilateral supraclavicular mass that was diagnosed as a poorly‑differentiated squamous cell carcinoma of unknown primary, following a fine‑needle aspiration biopsy (FNAB) and comprehensive clinical investigation. The analysis of a peripheral blood sample using the CellSearch system revealed the presence of circulating tumor cells (CTCs) that were positive for epithelial cell adhesion molecule (EpCAM) and cytokeratin (CK) expression. Since EpCAM is usually expressed in adenocarcinoma, an excisional biopsy of the right supraclavicular lymph node was performed. The patient was diagnosed with occult ovarian low‑grade serous carcinoma by immunohistochemistry. To the best of our knowledge, this is the first report to demonstrate that CTCs may be detected in the peripheral blood of a patient with cancer of unknown primary (CUP) by using the CellSearch system. A literature review was performed to analyze the diagnostic procedures of CUP metastatic to the cervical lymph nodes and the clinical features of CTCs.
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Copy and paste a formatted citation
Spandidos Publications style
He S, Li P, Chen X and Yu Z: Fluid biopsy for circulating tumor cells in an occult ovarian cancer patient exhibiting bilateral supraclavicular lymph node metastases: A case report. Oncol Lett 6: 448-452, 2013.
APA
He, S., Li, P., Chen, X., & Yu, Z. (2013). Fluid biopsy for circulating tumor cells in an occult ovarian cancer patient exhibiting bilateral supraclavicular lymph node metastases: A case report. Oncology Letters, 6, 448-452. https://doi.org/10.3892/ol.2013.1364
MLA
He, S., Li, P., Chen, X., Yu, Z."Fluid biopsy for circulating tumor cells in an occult ovarian cancer patient exhibiting bilateral supraclavicular lymph node metastases: A case report". Oncology Letters 6.2 (2013): 448-452.
Chicago
He, S., Li, P., Chen, X., Yu, Z."Fluid biopsy for circulating tumor cells in an occult ovarian cancer patient exhibiting bilateral supraclavicular lymph node metastases: A case report". Oncology Letters 6, no. 2 (2013): 448-452. https://doi.org/10.3892/ol.2013.1364
Copy and paste a formatted citation
x
Spandidos Publications style
He S, Li P, Chen X and Yu Z: Fluid biopsy for circulating tumor cells in an occult ovarian cancer patient exhibiting bilateral supraclavicular lymph node metastases: A case report. Oncol Lett 6: 448-452, 2013.
APA
He, S., Li, P., Chen, X., & Yu, Z. (2013). Fluid biopsy for circulating tumor cells in an occult ovarian cancer patient exhibiting bilateral supraclavicular lymph node metastases: A case report. Oncology Letters, 6, 448-452. https://doi.org/10.3892/ol.2013.1364
MLA
He, S., Li, P., Chen, X., Yu, Z."Fluid biopsy for circulating tumor cells in an occult ovarian cancer patient exhibiting bilateral supraclavicular lymph node metastases: A case report". Oncology Letters 6.2 (2013): 448-452.
Chicago
He, S., Li, P., Chen, X., Yu, Z."Fluid biopsy for circulating tumor cells in an occult ovarian cancer patient exhibiting bilateral supraclavicular lymph node metastases: A case report". Oncology Letters 6, no. 2 (2013): 448-452. https://doi.org/10.3892/ol.2013.1364
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