Oxygen metabolism in oral cancer: HIF and GLUTs (Review)

  • Authors:
    • Karuza Maria Alves Pereira
    • Filipe Nobre Chaves
    • Thales Salles Angelim Viana
    • Francisco Samuel Rodrigues Carvalho
    • Fábio Wildson Gurgel Costa
    • Ana Paula Negreiros Nunes Alves
    • Fabrício Bitu Sousa
  • View Affiliations

  • Published online on: June 3, 2013     https://doi.org/10.3892/ol.2013.1371
  • Pages: 311-316
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Abstract

Oral cancer is a significant cause of morbidity and mortality, and has a poor prognosis. This has encouraged additional studies into factors that may affect the development of this disease. The biological behavior of malignant neoplasms is complex. Studies have investigated the energy metabolism of tumor cells, in an endeavor to elucidate the tumor biology. The identification of molecular signatures and mechanisms, in order to understand tumor progression, may facilitate the identification of novel predictive and prognostic markers. Pathways that influence tumor progression, such as those involving hypoxia‑inducible factor (HIF) and glucose transporter (GLUT) proteins, have been the targets of recent studies.
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August 2013
Volume 6 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Pereira KM, Chaves FN, Viana TS, Carvalho FS, Costa FW, Alves AP and Sousa FB: Oxygen metabolism in oral cancer: HIF and GLUTs (Review). Oncol Lett 6: 311-316, 2013
APA
Pereira, K.M., Chaves, F.N., Viana, T.S., Carvalho, F.S., Costa, F.W., Alves, A.P., & Sousa, F.B. (2013). Oxygen metabolism in oral cancer: HIF and GLUTs (Review). Oncology Letters, 6, 311-316. https://doi.org/10.3892/ol.2013.1371
MLA
Pereira, K. M., Chaves, F. N., Viana, T. S., Carvalho, F. S., Costa, F. W., Alves, A. P., Sousa, F. B."Oxygen metabolism in oral cancer: HIF and GLUTs (Review)". Oncology Letters 6.2 (2013): 311-316.
Chicago
Pereira, K. M., Chaves, F. N., Viana, T. S., Carvalho, F. S., Costa, F. W., Alves, A. P., Sousa, F. B."Oxygen metabolism in oral cancer: HIF and GLUTs (Review)". Oncology Letters 6, no. 2 (2013): 311-316. https://doi.org/10.3892/ol.2013.1371