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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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September 2013 Volume 6 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Tissue factor‑targeted lidamycin inhibits growth and metastasis of colon carcinoma

  • Authors:
    • Qing Zhang
    • Xiujun Liu
    • Caihong Li
    • Dongsheng Liao
    • Zhigang Ouyang
    • Junnian Zheng
    • Xu Song
  • View Affiliations / Copyright

    Affiliations: Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P.R. China, Center for Functional Genomics and Bioinformatics, College of Life Science, Sichuan University, Chengdu, Sichuan 610064, P.R. China
  • Pages: 801-806
    |
    Published online on: July 3, 2013
       https://doi.org/10.3892/ol.2013.1437
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Abstract

Colon cancer is the third most common cancer in the world. The overexpression of tissue factor (TF) in colon cancer cells makes it an ideal target for colon cancer therapy. The purpose of the present study was to develop a TF‑targeting energized fusion protein, mlFVII‑LDP‑AE, which is composed of a mouse Factor VII light chain (mlFVII) as the targeting domain conjugated to the highly cytotoxic antibiotic lidamycin (LDM, LDP‑AE) as the effector domain. The potential efficacy of mlFVII‑LDP‑AE for mouse colon cancer therapy was tested in a mouse colon cancer subcutaneous xenograft model and a live metastasis model in BALB/c mice. mlFVII‑LDP‑AE showed a tumor growth inhibition rate of 91.2% (at a dose of 0.8 mg/kg) and a tumor metastasis inhibition rate of 84.7% (at a dose of 0.6 mg/kg). The results showed that mlFVII‑LDP‑AE was able to effectively inhibit the growth and metastasis of mouse colon cancer. As human TF and FVII have features similar to those of mice, human FVII light chain (hlFVII)‑targeted LDM (hlFVII‑LDP‑AE) may be expected to have therapeutic potential for human colon cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Q, Liu X, Li C, Liao D, Ouyang Z, Zheng J and Song X: Tissue factor‑targeted lidamycin inhibits growth and metastasis of colon carcinoma. Oncol Lett 6: 801-806, 2013.
APA
Zhang, Q., Liu, X., Li, C., Liao, D., Ouyang, Z., Zheng, J., & Song, X. (2013). Tissue factor‑targeted lidamycin inhibits growth and metastasis of colon carcinoma. Oncology Letters, 6, 801-806. https://doi.org/10.3892/ol.2013.1437
MLA
Zhang, Q., Liu, X., Li, C., Liao, D., Ouyang, Z., Zheng, J., Song, X."Tissue factor‑targeted lidamycin inhibits growth and metastasis of colon carcinoma". Oncology Letters 6.3 (2013): 801-806.
Chicago
Zhang, Q., Liu, X., Li, C., Liao, D., Ouyang, Z., Zheng, J., Song, X."Tissue factor‑targeted lidamycin inhibits growth and metastasis of colon carcinoma". Oncology Letters 6, no. 3 (2013): 801-806. https://doi.org/10.3892/ol.2013.1437
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Q, Liu X, Li C, Liao D, Ouyang Z, Zheng J and Song X: Tissue factor‑targeted lidamycin inhibits growth and metastasis of colon carcinoma. Oncol Lett 6: 801-806, 2013.
APA
Zhang, Q., Liu, X., Li, C., Liao, D., Ouyang, Z., Zheng, J., & Song, X. (2013). Tissue factor‑targeted lidamycin inhibits growth and metastasis of colon carcinoma. Oncology Letters, 6, 801-806. https://doi.org/10.3892/ol.2013.1437
MLA
Zhang, Q., Liu, X., Li, C., Liao, D., Ouyang, Z., Zheng, J., Song, X."Tissue factor‑targeted lidamycin inhibits growth and metastasis of colon carcinoma". Oncology Letters 6.3 (2013): 801-806.
Chicago
Zhang, Q., Liu, X., Li, C., Liao, D., Ouyang, Z., Zheng, J., Song, X."Tissue factor‑targeted lidamycin inhibits growth and metastasis of colon carcinoma". Oncology Letters 6, no. 3 (2013): 801-806. https://doi.org/10.3892/ol.2013.1437
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