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September 2013 Volume 6 Issue 3

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Article

An effective approach for treating unresectable hepatoblastoma in infants and children: Pre‑operative transcatheter arterial chemoembolization

  • Authors:
    • Jing Zhang
    • Fei Xu
    • Kunshan Chen
    • Shaoyi Zhou
    • Haibo Li
    • Chuanqiang Niu
    • Xiaoyun Tan
  • View Affiliations / Copyright

    Affiliations: Department of Interventional Radiology and Vacular Anomalies, Guangzhou Women and Children's Medical Center, Guangzhou Children's Hospital, Guangzhou, Guangdong 510623, P.R. China, Department of Respiratory Medicine, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330006, P.R. China
  • Pages: 850-854
    |
    Published online on: July 3, 2013
       https://doi.org/10.3892/ol.2013.1444
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Abstract

The objective of the present study was to investigate the feasibility and efficacy of pre‑operative transcatheter arterial chemoembolization (TACE) for unresectable hepatoblastoma in infants and children. A total of 24 patients (14 males and 10 females) with unresectable hepatoblastoma, aged between 26 days and 41 months, were treated with pre‑operative TACE between March 2007 and March 2011. All cases were confirmed by computed tomography (CT) and liver tumor biopsy prior to TACE. Arteriography was performed and the chemoembolization mixture (pirarubicin and cisplatin emulsified in lipiodol) was injected, followed by polyvinyl alcohol (PVA). The procedure was performed one to four times depending on the patient's response. There was a significant reduction in tumor volume associated with decreased α-fetoprotein (AFP) levels following TACE. Tumor volumes decreased by between 46.1 and 90.2%, with a mean value of 72%. The AFP levels fell by between 63.8 and 99.9%, with a mean value of 95.7%. A total of 22 cases underwent subsequent safe complete surgical resection and the remaining two patients accepted a partial resection. To evaluate the toxicity of TACE, the alanine aminotransferase (ALT), serum creatinine (Cr) and creatine kinase (CK) levels of the patients were measured to assess liver, renal and cardiac function, respectively. The results showed that no marked chemotherapeutic agent-induced toxicity occurred during TACE. It may be concluded that TACE is an effective and feasible pre‑operative therapeutic approach for treating unresectable hepatoblastoma and that it may improve the resectability of bulky liver tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Xu F, Chen K, Zhou S, Li H, Niu C and Tan X: An effective approach for treating unresectable hepatoblastoma in infants and children: Pre‑operative transcatheter arterial chemoembolization. Oncol Lett 6: 850-854, 2013.
APA
Zhang, J., Xu, F., Chen, K., Zhou, S., Li, H., Niu, C., & Tan, X. (2013). An effective approach for treating unresectable hepatoblastoma in infants and children: Pre‑operative transcatheter arterial chemoembolization. Oncology Letters, 6, 850-854. https://doi.org/10.3892/ol.2013.1444
MLA
Zhang, J., Xu, F., Chen, K., Zhou, S., Li, H., Niu, C., Tan, X."An effective approach for treating unresectable hepatoblastoma in infants and children: Pre‑operative transcatheter arterial chemoembolization". Oncology Letters 6.3 (2013): 850-854.
Chicago
Zhang, J., Xu, F., Chen, K., Zhou, S., Li, H., Niu, C., Tan, X."An effective approach for treating unresectable hepatoblastoma in infants and children: Pre‑operative transcatheter arterial chemoembolization". Oncology Letters 6, no. 3 (2013): 850-854. https://doi.org/10.3892/ol.2013.1444
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Xu F, Chen K, Zhou S, Li H, Niu C and Tan X: An effective approach for treating unresectable hepatoblastoma in infants and children: Pre‑operative transcatheter arterial chemoembolization. Oncol Lett 6: 850-854, 2013.
APA
Zhang, J., Xu, F., Chen, K., Zhou, S., Li, H., Niu, C., & Tan, X. (2013). An effective approach for treating unresectable hepatoblastoma in infants and children: Pre‑operative transcatheter arterial chemoembolization. Oncology Letters, 6, 850-854. https://doi.org/10.3892/ol.2013.1444
MLA
Zhang, J., Xu, F., Chen, K., Zhou, S., Li, H., Niu, C., Tan, X."An effective approach for treating unresectable hepatoblastoma in infants and children: Pre‑operative transcatheter arterial chemoembolization". Oncology Letters 6.3 (2013): 850-854.
Chicago
Zhang, J., Xu, F., Chen, K., Zhou, S., Li, H., Niu, C., Tan, X."An effective approach for treating unresectable hepatoblastoma in infants and children: Pre‑operative transcatheter arterial chemoembolization". Oncology Letters 6, no. 3 (2013): 850-854. https://doi.org/10.3892/ol.2013.1444
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