Hereditary gynecological tumors associated with Peutz‑Jeghers syndrome (Review)

  • Authors:
    • Kouji Banno
    • Iori Kisu
    • Megumi Yanokura
    • Kenta Masuda
    • Arisa Ueki
    • Yusuke Kobayashi
    • Akira Hirasawa
    • Daisuke Aoki
  • View Affiliations

  • Published online on: August 16, 2013     https://doi.org/10.3892/ol.2013.1527
  • Pages: 1184-1188
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Abstract

Peutz‑Jeghers syndrome (PJS) is an autosomal dominant disease that is characterized by gastrointestinal hamartomatous polyposis and mucocutaneous melanin spots. The tumor suppressor gene, STK11/LKB1, which is located on chromosome 19p13.3, has been reported to be responsible for this condition. PJS is complicated by benign and malignant tumors of various organs and complications from rare diseases, including sex cord tumor with annular tubules (SCTAT) and minimal deviation adenocarcinoma (MDA), which have also recently attracted attention in the field of gynecology. Among the total MDA cases, 10% are complications of PJS, and mutations in the STK11 gene are closely associated with the development and prognosis of MDA. Furthermore, a new type of uterine cervical tumor, lobular endocervical glandular hyperplasia (LEGH), has been identified and has been predicted to be a precancerous lesion of MDA. The first case of LEGH induced by a germline STK11 mutation has also been described. A high risk of endometrial cancer in PJS has also been reported. These developments suggest that PJS is an important syndrome of hereditary gynecological tumors that requires further study.
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November 2013
Volume 6 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Banno K, Kisu I, Yanokura M, Masuda K, Ueki A, Kobayashi Y, Hirasawa A and Aoki D: Hereditary gynecological tumors associated with Peutz‑Jeghers syndrome (Review). Oncol Lett 6: 1184-1188, 2013
APA
Banno, K., Kisu, I., Yanokura, M., Masuda, K., Ueki, A., Kobayashi, Y. ... Aoki, D. (2013). Hereditary gynecological tumors associated with Peutz‑Jeghers syndrome (Review). Oncology Letters, 6, 1184-1188. https://doi.org/10.3892/ol.2013.1527
MLA
Banno, K., Kisu, I., Yanokura, M., Masuda, K., Ueki, A., Kobayashi, Y., Hirasawa, A., Aoki, D."Hereditary gynecological tumors associated with Peutz‑Jeghers syndrome (Review)". Oncology Letters 6.5 (2013): 1184-1188.
Chicago
Banno, K., Kisu, I., Yanokura, M., Masuda, K., Ueki, A., Kobayashi, Y., Hirasawa, A., Aoki, D."Hereditary gynecological tumors associated with Peutz‑Jeghers syndrome (Review)". Oncology Letters 6, no. 5 (2013): 1184-1188. https://doi.org/10.3892/ol.2013.1527