A rare case of primary nodal hemangioendothelioma
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- Published online on: October 15, 2013 https://doi.org/10.3892/ol.2013.1631
- Pages: 1759-1761
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Abstract
Primary vascular tumors of the lymph nodes other than Kaposi's sarcoma are rare. The present study describes the case of a primary hemangioendothelioma in a cervical lymph node in a patient treated for a carcinoma of the large bowel. Microscopically, the structure of the lymph node was completely substituted by tumoral proliferation, with an architectural pattern consisting of anastomosing vascular channels, a number of which contained papillary projections or a tuft-like structure. This study demonstrates the potential diagnostic errors and hypothesizes the pathogenesis of this type of lesion; a vascular endothelial growth factor (VEGF)/VEGF receptor‑3 (VEGFR‑3) autocrine loop may be activated.
