Gallic acid reduces cell viability, proliferation, invasion and angiogenesis in human cervical cancer cells

  • Authors:
    • Bing Zhao
    • Mengcai Hu
  • View Affiliations

  • Published online on: October 15, 2013     https://doi.org/10.3892/ol.2013.1632
  • Pages: 1749-1755
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Abstract

Gallic acid is a trihydroxybenzoic acid, also known as 3,4,5‑trihydroxybenzoic acid, which is present in plants worldwide, including Chinese medicinal herbs. Gallic acid has been shown to have cytotoxic effects in certain cancer cells, without damaging normal cells. The objective of the present study was to determine whether gallic acid is able to inhibit human cervical cancer cell viability, proliferation and invasion and suppress cervical cancer cell‑mediated angiogenesis. Treatment of HeLa and HTB‑35 human cancer cells with gallic acid decreased cell viability in a dose‑dependent manner. BrdU proliferation and tube formation assays indicated that gallic acid significantly decreased human cervical cancer cell proliferation and tube formation in human umbilical vein endothelial cells, respectively. Additionally, gallic acid decreased HeLa and HTB‑35 cell invasion in vitro. Western blot analysis demonstrated that the expression of ADAM17, EGFR, p‑Akt and p‑Erk was suppressed by gallic acid in the HeLa and HTB‑35 cell lines. These data indicate that the suppression of ADAM17 and the downregulation of the EGFR, Akt/p‑Akt and Erk/p‑Erk signaling pathways may contribute to the suppression of cancer progression by Gallic acid. Gallic acid may be a valuable candidate for the treatment of cervical cancer.
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December 2013
Volume 6 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhao B and Hu M: Gallic acid reduces cell viability, proliferation, invasion and angiogenesis in human cervical cancer cells. Oncol Lett 6: 1749-1755, 2013.
APA
Zhao, B., & Hu, M. (2013). Gallic acid reduces cell viability, proliferation, invasion and angiogenesis in human cervical cancer cells. Oncology Letters, 6, 1749-1755. https://doi.org/10.3892/ol.2013.1632
MLA
Zhao, B., Hu, M."Gallic acid reduces cell viability, proliferation, invasion and angiogenesis in human cervical cancer cells". Oncology Letters 6.6 (2013): 1749-1755.
Chicago
Zhao, B., Hu, M."Gallic acid reduces cell viability, proliferation, invasion and angiogenesis in human cervical cancer cells". Oncology Letters 6, no. 6 (2013): 1749-1755. https://doi.org/10.3892/ol.2013.1632