Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
2014-April Volume 7 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
2014-April Volume 7 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Stereotactic body radiation therapy for centrally‑located lung tumors

  • Authors:
    • Ge Shen
    • Ying‑Jie Wang
    • Wen‑Jiang Shen
    • Zhen‑Shan Zhou
    • Jun‑Liang Wang
    • Hong‑Guo Sheng
    • Da‑Peng Dong
    • Ming Zhou
    • Gang Yang
    • Qin‑Wen Wang
    • Yanjun Zeng
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, P.R. China, Army Radiation Cancer Center and Department of Radiation Oncology, Air Force General Hospital, Beijing 100036, P.R. China, Biomedical Engineering Center, Beijing University of Technology, Beijing 100022, P.R. China
  • Pages: 1292-1296
    |
    Published online on: January 21, 2014
       https://doi.org/10.3892/ol.2014.1815
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The application of high‑dose irradiation to centrally‑located lung tumors is generally considered to be of high risk in causing bronchial injury. The aim of the present retrospective study was to investigate the safety and efficacy of stereotactic body radiation therapy (SBRT) for patients with centrally‑located lung tumors. In total, 28 patients who underwent SBRT for lung tumors within 2 cm of a major bronchus were retrospectively analyzed. The median total dose prescribed was 45 Gy (range, 36.3‑52.5 Gy), the median fraction was 12 (range, 10‑15) and the median dose per fraction was 3.6 Gy (range, 3‑5 Gy). The median follow‑up period for the surviving patients was 14 months (range, 10‑41 months). The local control rate of SBRT was 100%, with a complete response (CR) rate of 32.1% (9/28); a partial response (PR) rate of 50% (14/28) and a stable disease (SD) rate of 17.9% (5/28). In total, 15 patients survived and 13 patients succumbed; 11 patients succumbed to tumor progression, one to congestive heart failure and one to a brain hemorrhage. The main side‑effects included grade 2 esophagitis (17.9%; 5/28) atelectasis (10.7%; 3/28) and grade 2 late radiation pneumonitis (7.1%; 2/28). Severe late toxicity (≥ grade 3) was not observed in any patient. SBRT is an effective and safe therapy for centrally‑located lung tumors.
View Figures

Figure 1

Figure 2

View References

1 

Xia T, Li H, Sun Q, Wang Y, Fan N, Yu Y, Li P and Chang JY: Promising clinical outcome of stereotactic body radiation therapy for patients with inoperable Stage I/II non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 66:117–125. 2006. View Article : Google Scholar

2 

Wu D, Zhu H, Tang H, Li C and Xu F: Clinical analysis of stereotactic body radiation therapy using extracranial γ knife for patients with mainly bulky inoperable early stage non-small cell lung carcinoma. Radiat Oncol. 6:842011.

3 

Haasbeek CJ, Senan S, Smit EF, Paul MA, Slotman BJ and Lagerwaard FJ: Critical review of nonsurgical treatment options for stage I non-small cell lung cancer. Oncologist. 13:309–319. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Chi A, Liao Z, Nguyen NP, Xu J, Stea B and Komaki R: Systemic review of the patterns of failure following stereotactic body radiation therapy in early-stage non-small-cell lung cancer: clinical implications. Radiother Oncol. 94:1–11. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Palma D and Senan S: Stereotactic radiation therapy: changing treatment paradigms for stage I nonsmall cell lung cancer. Curr Opin Oncol. 23:133–139. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Palma D, Visser O, Lagerwaard FJ, Belderbos J, Slotman BJ and Senan S: Impact of introducing stereotactic lung radiotherapy for elderly patients with stage I non-small-cell lung cancer: a population-based time-trend analysis. J Clin Oncol. 28:5153–5159. 2010. View Article : Google Scholar

7 

Timmerman R, McGarry R, Yiannoutsos C, Papiez L, Tudor K, DeLuca J, Ewing M, Abdulrahman R, DesRosiers C, Williams M and Fletcher J: Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer. J Clin Oncol. 24:4833–4839. 2006. View Article : Google Scholar

8 

Chang JY, Balter PA, Dong L, Yang Q, Liao Z, Jeter M, Bucci MK, McAleer MF, Mehran RJ, Roth JA and Komaki R: Stereotactic body radiation therapy in centrally and superiorly located stage I or isolated recurrent non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 72:967–971. 2008. View Article : Google Scholar

9 

Lagerwaard FJ, Haasbeek CJ, Smit EF, Slotman BJ and Senan S: Outcomes of risk-adapted fractionated stereotactic radiotherapy for stage I non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 70:685–692. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Haasbeek CJ, Lagerwaard FJ, Slotman BJ and Senan S: Outcomes of stereotactic ablative radiotherapy for centrally-located early-stage lung cancer. J Thorac Oncol. 6:2036–2043. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Oshiro Y, Aruga T, Tsuboi K, Marino K, Hara R, Sanayama Y and Itami J: Stereotactic body radiotherapy for lung tumors at the pulmonary hilum. Strahlenther Onkol. 186:274–279. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Unger K, Ju A, Oermann E, Suy S, Yu X, Vahdat S, Subramaniam D, Harter KW, Collins SP, Dritschilo A, Anderson E and Collins BT: CyberKnife for hilar lung tumors: report of clinical response and toxicity. J Hematol Oncol. 3:392010. View Article : Google Scholar : PubMed/NCBI

13 

Nuyttens JJ, van der Voort van Zyp NC, Praag J, Aluwini S, van Klaveren RJ, Verhoef C, Pattynama PM and Hoogeman MS: Outcome of four-dimensional stereotactic radiotherapy for centrally-located lung tumors. Radiother Oncol. 102:383–387. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Joyner M, Salter BJ, Papanikolaou N and Fuss M: Stereotactic body radiation therapy for centrally-located lung lesions. Acta Oncol. 45:802–807. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Shen G, Wang YJ, Sheng HG, Duan XP, Wang JL, Zhang WJ, Zhou ZS, Zhu GY and Xia TY: Double CT imaging can measure the respiratory movement of small pulmonary tumors during stereotactic ablative radiotherapy. J Thorac Dis. 4:131–140. 2012.PubMed/NCBI

16 

Zhang LP, Nie Q, Kang JB, Wang B, Cai CL, Li JG and Qi WJ: Efficacy of whole body γ-knife radiotherapy combined with thermochemotherapy on locally advanced pancreatic cancer. Ai Zheng. 27:1204–1207. 2008.(In Chinese).

17 

Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, et al: New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst. 92:205–216. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Colevas AD and Setser A: The NCI Common Terminology Criteria for Adverse Events (CTCAE) v 3.0 is the new standard for oncology clinical trials. J Clin Oncol. 22(July 15 Suppl): 60982004.

19 

Miller KL, Shafman TD, Anscher MS, Zhou SM, Clough RW, Garst JL, Crawford J, Rosenman J, Socinski MA, Blackstock W, Sibley GS and Marks LB: Bronchial stenosis: an underreported complication of high-dose external beam radiotherapy for lung cancer? Int J Radiat Oncol Biol Phys. 61:64–69. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Bral S, Gevaert T, Linthout N, Versmessen H, Collen C, Engels B, Verdries D, Everaert H, Christian N, De Ridder M and Storme G: Prospective, risk-adapted strategy of stereotactic body radiotherapy for early-stage non-small-cell lung cancer: results of a Phase II trial. Int J Radiat Oncol Biol Phys. 80:1343–1349. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Wulf J, Hädinger U, Oppitz U, Thiele W, Ness-Dourdoumas R and Flentje M: Stereotactic radiotherapy of targets in the lung and liver. Strahlenther Onkol. 177:645–655. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Cheruvu P, Metcalfe SK, Metcalfe J, Chen Y, Okunieff P and Milano MT: Comparison of outcomes in patients with stage III versus limited stage IV non-small cell lung cancer. Radiat Oncol. 6:802011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shen G, Wang YJ, Shen WJ, Zhou ZS, Wang JL, Sheng HG, Dong DP, Zhou M, Yang G, Wang QW, Wang QW, et al: Stereotactic body radiation therapy for centrally‑located lung tumors. Oncol Lett 7: 1292-1296, 2014.
APA
Shen, G., Wang, Y., Shen, W., Zhou, Z., Wang, J., Sheng, H. ... Zeng, Y. (2014). Stereotactic body radiation therapy for centrally‑located lung tumors. Oncology Letters, 7, 1292-1296. https://doi.org/10.3892/ol.2014.1815
MLA
Shen, G., Wang, Y., Shen, W., Zhou, Z., Wang, J., Sheng, H., Dong, D., Zhou, M., Yang, G., Wang, Q., Zeng, Y."Stereotactic body radiation therapy for centrally‑located lung tumors". Oncology Letters 7.4 (2014): 1292-1296.
Chicago
Shen, G., Wang, Y., Shen, W., Zhou, Z., Wang, J., Sheng, H., Dong, D., Zhou, M., Yang, G., Wang, Q., Zeng, Y."Stereotactic body radiation therapy for centrally‑located lung tumors". Oncology Letters 7, no. 4 (2014): 1292-1296. https://doi.org/10.3892/ol.2014.1815
Copy and paste a formatted citation
x
Spandidos Publications style
Shen G, Wang YJ, Shen WJ, Zhou ZS, Wang JL, Sheng HG, Dong DP, Zhou M, Yang G, Wang QW, Wang QW, et al: Stereotactic body radiation therapy for centrally‑located lung tumors. Oncol Lett 7: 1292-1296, 2014.
APA
Shen, G., Wang, Y., Shen, W., Zhou, Z., Wang, J., Sheng, H. ... Zeng, Y. (2014). Stereotactic body radiation therapy for centrally‑located lung tumors. Oncology Letters, 7, 1292-1296. https://doi.org/10.3892/ol.2014.1815
MLA
Shen, G., Wang, Y., Shen, W., Zhou, Z., Wang, J., Sheng, H., Dong, D., Zhou, M., Yang, G., Wang, Q., Zeng, Y."Stereotactic body radiation therapy for centrally‑located lung tumors". Oncology Letters 7.4 (2014): 1292-1296.
Chicago
Shen, G., Wang, Y., Shen, W., Zhou, Z., Wang, J., Sheng, H., Dong, D., Zhou, M., Yang, G., Wang, Q., Zeng, Y."Stereotactic body radiation therapy for centrally‑located lung tumors". Oncology Letters 7, no. 4 (2014): 1292-1296. https://doi.org/10.3892/ol.2014.1815
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team