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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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2014-April Volume 7 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Related to testes‑specific, vespid and pathogenesis protein‑1 is regulated by methylation in glioblastoma

  • Authors:
    • Elad Jacoby
    • Michal Yalon
    • Moshe Leitner
    • Zvi R. Cohen
    • Yehudit Cohen
    • Tamar Fisher
    • Sarit Eder
    • Ninette Amariglio
    • Gideon Rechavi
    • Simona Cazacu
    • Cunli Xiang
    • Tom Mikkelsen
    • Chaya Brodie
    • Amos Toren
  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Hematology and Oncology, The Chaim Sheba Medical Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel, Cancer Research Center, The Chaim Sheba Medical Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel, Department of Neurosurgery, The Chaim Sheba Medical Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel, Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA
  • Pages: 1209-1212
    |
    Published online on: January 27, 2014
       https://doi.org/10.3892/ol.2014.1829
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Abstract

Related to testes‑specific, vespid and pathogenesis protein‑1 (RTVP‑1), also known as glioma pathogenesis‑related protein 1, is highly expressed and has oncogenic features in glioblastoma (GBM; World Health Organization class IV). Promoter methylation has been found to control RTVP‑1 expression in prostate carcinoma, Wilms' tumor, acute myeloid leukemia and melanoma. In this bi‑institutional study, the methylation status of RTVP‑1 in astrocytic brain malignancies (GBM and oligodendroglioma) was examined. The RTVP‑1 promoter was hypomethylated in GBM compared with non‑tumor brain samples, but was hypermethylated in oligodendroglioma. RTVP‑1 methylation correlated with RTVP‑1 expression at the mRNA level. In GBM, hypermethylation of the RTVP‑1 promoter was associated with improved overall survival although with no statistical significance.
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1 

Louis DN, Ohgaki H, Wiestler OD, et al: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 114:97–109. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Jeswani S, Nuño M, Folkerts V and Bigg J: Comparison of survival between cerebellar and supratentorial glioblastoma patients: surveillance, epidemiology, and end results (SEER) analysis. Neurosurgery. 73:240–246. 2013. View Article : Google Scholar

3 

Esteller M: Epigenetics in cancer. N Engl J Med. 358:1148–1159. 2008. View Article : Google Scholar

4 

Noushmehr H, Weisenberger DJ, Diefes K, et al: Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell. 17:510–522. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Martinez R, Martin-Subero JI, Rohde V, et al: A microarray-based DNA methylation study of glioblastoma multiforme. Epigenetics. 4:255–264. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Murphy EV, Zhang Y, Zhu W, et al: The human glioma pathogenesis-related protein is structurally related to plant pathogenesis-related proteins and its gene is expressed specifically in brain tumors. Gene. 159:131–135. 1995. View Article : Google Scholar

7 

Rich T, Chen P, Furman F, et al: RTVP-1, a novel human gene with sequence similarity to genes of diverse species, is expressed in tumor cell lines of glial but not neuronal origin. Gene. 180:125–130. 1996. View Article : Google Scholar

8 

Rosenzweig T, Ziv-Av A, Xiang C, et al: Related to testes-specific, vespid, and pathogenesis protein-1 (RTVP-1) is overexpressed in gliomas and regulates the growth, survival, and invasion of glioma cells. Cancer Res. 66:4139–4148. 2006. View Article : Google Scholar

9 

Xiang C, Sarid R, Cazacu S, et al: Cloning and characterization of human RTVP-1b, a novel splice variant of RTVP-1 in glioma cells. Biochem Biophys Res Commun. 362:612–618. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Ren C, Li L, Yang G, et al: RTVP-1, a tumor suppressor inactivated by methylation in prostate cancer. Cancer Res. 64:969–976. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Liang T, Tan T, Xiao Y, et al: Methylation and expression of glioma pathogenesis-related protein 1 gene in acute myeloid leukemia. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 34:388–394. 2009.(In Chinese).

12 

Chilukamarri L, Hancock AL, Malik S, et al: Hypomethylation and aberrant expression of the glioma pathogenesis-related 1 gene in Wilms tumors. Neoplasia. 9:970–978. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Awasthi A, Woolley AG, Lecomte FJ, et al: Variable expression of GLIPR1 correlates with invasive potential in melanoma cells. Front Oncol. 3:2252013. View Article : Google Scholar : PubMed/NCBI

14 

Ehrich M, Nelson MR, Stanssens P, et al: Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry. Proc Natl Acad Sci USA. 102:15785–15790. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Bier A, Giladi N, Kronfeld N, et al: MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1. Oncotarget. 4:665–676. 2013.PubMed/NCBI

16 

Ren C, Li L, Goltsov AA, et al: mRTVP-1, a novel p53 target gene with proapoptotic activities. Mol Cell Biol. 22:3345–3357. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Li L, Fattah EA, Cao G, et al: Glioma pathogenesis-related protein 1 exerts tumor suppressor activities through proapoptotic reactive oxygen species-c-Jun-NH2 kinase signaling. Cancer Res. 68:434–443. 2008. View Article : Google Scholar

18 

Thompson TC: Glioma pathogenesis-related protein 1: tumor-suppressor activities and therapeutic potential. Yonsei Med J. 51:479–483. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Dong SM, Pang JC, Poon WS, et al: Concurrent hypermethylation of multiple genes is associated with grade of oligodendroglial tumors. J Neuropathol Exp Neurol. 60:808–816. 2001.PubMed/NCBI

20 

Wolter M, Reifenberger J, Blaschke B, et al: Oligodendroglial tumors frequently demonstrate hypermethylation of the CDKN2A (MTS1, p16INK4a), p14ARF, and CDKN2B (MTS2, p15INK4b) tumor suppressor genes. J Neuropathol Exp Neurol. 60:1170–1180. 2001.

21 

Noushmehr H, Weisenberger DJ, Diefes K, et al: Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell. 17:510–522. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Everhard S, Tost J, El Abdalaoui H, et al: Identification of regions correlating MGMT promoter methylation and gene expression in glioblastomas. Neuro Oncol. 11:348–356. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jacoby E, Yalon M, Leitner M, Cohen ZR, Cohen Y, Fisher T, Eder S, Amariglio N, Rechavi G, Cazacu S, Cazacu S, et al: Related to testes‑specific, vespid and pathogenesis protein‑1 is regulated by methylation in glioblastoma. Oncol Lett 7: 1209-1212, 2014.
APA
Jacoby, E., Yalon, M., Leitner, M., Cohen, Z.R., Cohen, Y., Fisher, T. ... Toren, A. (2014). Related to testes‑specific, vespid and pathogenesis protein‑1 is regulated by methylation in glioblastoma. Oncology Letters, 7, 1209-1212. https://doi.org/10.3892/ol.2014.1829
MLA
Jacoby, E., Yalon, M., Leitner, M., Cohen, Z. R., Cohen, Y., Fisher, T., Eder, S., Amariglio, N., Rechavi, G., Cazacu, S., Xiang, C., Mikkelsen, T., Brodie, C., Toren, A."Related to testes‑specific, vespid and pathogenesis protein‑1 is regulated by methylation in glioblastoma". Oncology Letters 7.4 (2014): 1209-1212.
Chicago
Jacoby, E., Yalon, M., Leitner, M., Cohen, Z. R., Cohen, Y., Fisher, T., Eder, S., Amariglio, N., Rechavi, G., Cazacu, S., Xiang, C., Mikkelsen, T., Brodie, C., Toren, A."Related to testes‑specific, vespid and pathogenesis protein‑1 is regulated by methylation in glioblastoma". Oncology Letters 7, no. 4 (2014): 1209-1212. https://doi.org/10.3892/ol.2014.1829
Copy and paste a formatted citation
x
Spandidos Publications style
Jacoby E, Yalon M, Leitner M, Cohen ZR, Cohen Y, Fisher T, Eder S, Amariglio N, Rechavi G, Cazacu S, Cazacu S, et al: Related to testes‑specific, vespid and pathogenesis protein‑1 is regulated by methylation in glioblastoma. Oncol Lett 7: 1209-1212, 2014.
APA
Jacoby, E., Yalon, M., Leitner, M., Cohen, Z.R., Cohen, Y., Fisher, T. ... Toren, A. (2014). Related to testes‑specific, vespid and pathogenesis protein‑1 is regulated by methylation in glioblastoma. Oncology Letters, 7, 1209-1212. https://doi.org/10.3892/ol.2014.1829
MLA
Jacoby, E., Yalon, M., Leitner, M., Cohen, Z. R., Cohen, Y., Fisher, T., Eder, S., Amariglio, N., Rechavi, G., Cazacu, S., Xiang, C., Mikkelsen, T., Brodie, C., Toren, A."Related to testes‑specific, vespid and pathogenesis protein‑1 is regulated by methylation in glioblastoma". Oncology Letters 7.4 (2014): 1209-1212.
Chicago
Jacoby, E., Yalon, M., Leitner, M., Cohen, Z. R., Cohen, Y., Fisher, T., Eder, S., Amariglio, N., Rechavi, G., Cazacu, S., Xiang, C., Mikkelsen, T., Brodie, C., Toren, A."Related to testes‑specific, vespid and pathogenesis protein‑1 is regulated by methylation in glioblastoma". Oncology Letters 7, no. 4 (2014): 1209-1212. https://doi.org/10.3892/ol.2014.1829
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