Related to testes‑specific, vespid and pathogenesis protein‑1 is regulated by methylation in glioblastoma

Jacoby,Elad; Yalon,Michal; Leitner,Moshe; Cohen,Zvi R.; Cohen,Yehudit; Fisher,Tamar; Eder,Sarit; Amariglio,Ninette; Rechavi,Gideon; Cazacu,Simona; Xiang,Cunli; Mikkelsen,Tom; Brodie,Chaya; Toren,Amos

doi:10.3892/ol.2014.1829

Related to testes‑specific, vespid and pathogenesis protein‑1 is regulated by methylation in glioblastoma

Authors:
- Elad Jacoby
- Michal Yalon
- Moshe Leitner
- Zvi R. Cohen
- Yehudit Cohen
- Tamar Fisher
- Sarit Eder
- Ninette Amariglio
- Gideon Rechavi
- Simona Cazacu
- Cunli Xiang
- Tom Mikkelsen
- Chaya Brodie
- Amos Toren
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Affiliations: Department of Pediatric Hematology and Oncology, The Chaim Sheba Medical Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel, Cancer Research Center, The Chaim Sheba Medical Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel, Department of Neurosurgery, The Chaim Sheba Medical Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel, Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA
Published online on: January 27, 2014 https://doi.org/10.3892/ol.2014.1829
Pages: 1209-1212

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Abstract

Related to testes‑specific, vespid and pathogenesis protein‑1 (RTVP‑1), also known as glioma pathogenesis‑related protein 1, is highly expressed and has oncogenic features in glioblastoma (GBM; World Health Organization class IV). Promoter methylation has been found to control RTVP‑1 expression in prostate carcinoma, Wilms' tumor, acute myeloid leukemia and melanoma. In this bi‑institutional study, the methylation status of RTVP‑1 in astrocytic brain malignancies (GBM and oligodendroglioma) was examined. The RTVP‑1 promoter was hypomethylated in GBM compared with non‑tumor brain samples, but was hypermethylated in oligodendroglioma. RTVP‑1 methylation correlated with RTVP‑1 expression at the mRNA level. In GBM, hypermethylation of the RTVP‑1 promoter was associated with improved overall survival although with no statistical significance.

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